computer-aided-three-dimensional-visualization-treatment-locally

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

The diagnosis and treatment of locally advanced thyroid carcinoma are challenging. The challenge lies in the evaluation of the tumor scope and the ...

Affiliated Cancer Hospital of University of Electronic Science and Technology of China

To analyze a producing method for modified pectoralis major myocutaneous (PMM) flap, with maintaining the function of pectoralis major muscle.

[Application of modified pectoralis major myocutaneous flap in advanced head and neck cancer].

[Radiation-induced a soft tissue giant cell tumor of the anterior neck: one case report].

To evaluate the benefits of CT angiography (CTA) in preoperative mapping of anterolateral thigh perforator flap (ALTPF) for reconstruction of defect after head and neck cancer resection.

[Application of CT angiography in design of anterolateral thigh perforator flap for reconstruction of defect after head and neck cancer resection].

To explore the value of free latissimus dorsimyocutaneous flap in repairing severe defect of head and neck after resection of tumor.

[Transplantation of free latissimus dorsimyocutaneous flaps for repairing head and neck defect after tumor resection].

Normal cell cycle progression and proliferation of palatal mesenchymal cells are important for palatal development. As targets of miR-17-92, E2F transcription factors family has been suggested to induce the transcription of miR-17-92 in several cell types. In the present study, we sought to investigate whether this negative feedback loop exists in mouse PMCs and what the function of this negative feedback loop would be in palatal mesenchymal cells. Using GeneMANIA, we revealed that the most important function of experimentally verified targets of miR-17-92 is cell cycle regulation. E2F1 and E2F3, but not E2F2, were extensively expressed in mouse palate. Over-expression of E2F1 significantly increased the expression of all the members of miR-17-92. After increased by E2F1, miR-17 and miR-20a may negatively target E2F1, and thereby prevent the cells from excessive proliferation. We suggest that the negative feedback loop between E2F1 and miR-17-92 may contribute to palatal development by regulating the proliferation and cell cycle of palatal mesenchymal cells.

Article	Year
[Application of modified pectoralis major myocutaneous flap in advanced head and neck cancer]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery\| PubMed ID: 17649935	2007
[Radiation-induced a soft tissue giant cell tumor of the anterior neck: one case report]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery\| PubMed ID: 26081094	2015
[Application of CT angiography in design of anterolateral thigh perforator flap for reconstruction of defect after head and neck cancer resection]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery\| PubMed ID: 26178049	2015
[Transplantation of free latissimus dorsimyocutaneous flaps for repairing head and neck defect after tumor resection]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery\| PubMed ID: 26888135	2015
An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells. Scientific reports\| PubMed ID: 28698574	2017

Zhaohui Wang

Biography

JoVE Journal Publications

Other Publications