rotating-intraocular-lens-to-prevent-posterior-capsular-opacification

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries

Posterior capsule opacification (PCO) is a common postoperative complication of extracapsular cataract surgery, which is caused by the proliferation and ...

Peking University Third Hospital

To evaluate photopic and mesopic color discrimination in patients with different types of light-filtering intraocular lenses (IOLs).

Color discrimination by patients with different types of light-filtering intraocular lenses.

To investigate the survival of SD rat retinal cells after irradiated with 460-480 nm wavelength blue light at three different irradiance.

[Influence of 460-480 nm wavelength light at three different irradiance on retina tissue of SD rats].

The mechanism of blue light-induced retinal ganglion cell (RGC) injury is poorly understood. In this study, we established a patented light-emitting diode-based system to study the effects of long-term blue light exposure under culture conditions on RGC-5 cells. Long-term blue light exposure significantly reduced cell viability in a time-dependent manner and induced apoptosis and necrosis in RGC-5 cells. Long-term blue light exposure marked an increase in the expression of Bax and active Caspase-3 (p17), which was accompanied by Bcl-2 down-regulation, and displayed features of the mitochondria-dependent apoptosis pathway. Blue light exposure also increased the generation of reactive oxygen species (ROS), and was a strong inducer of ROS-sensitive protein nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression. Moreover, blue light exposure constitutively activated p38 mitogen-activated protein kinases and c-Jun NH2-terminal kinase (JNK), as well as induced the phosphorylation of extracellular signal-regulated kinase in the early phase, in blue light-exposed RGC-5 cells. The protein expression of c-jun and c-fos was further enhanced after RGC-5 cells were exposed to blue light. Taken together, these findings indicated that blue light induced RGC-5 cell line death in dependence upon exposure duration. The potential mechanisms for this phenomenon might be via activated mitochondria-dependent apoptosis, increased ROS production and protein expressions of Nrf2 and HO-1, and activated JNK/p38 MAPK signaling pathways.

Long-term blue light exposure induces RGC-5 cell death in vitro: involvement of mitochondria-dependent apoptosis, oxidative stress, and MAPK signaling pathways.

To evaluate the torque and flattening effect of steep meridian clear corneal incisions on cornea in phacoemulsification when posterior cornea surface measurements were considered.

Effect of steep meridian clear corneal incisions in phacoemulsification.

To assess quantitative changes of the macula in diabetic eyes after cataract surgery using optical coherence tomography (OCT) and to estimate the incidence of development or worsening of macular edema (ME) in diabetic eyes with or without pre-existing ME.

Macular edema after cataract surgery in diabetic eyes evaluated by optical coherence tomography.

This study aimed to evaluate the visual and morphological outcomes of intravitreal anti-VEGF therapy and the recurrence for idiopathic choroidal neovascularization (ICNV).

Evaluation of efficacy and recurrence for anti-vascular endothelial growth factor therapy in idiopathic choroidal neovascularization.

To evaluate the accuracy of an advanced manual corneal astigmatic marking method for toric intraocular lens (IOL) implantation.

Rotational slit-beam marking: an advanced manual corneal astigmatic marking method for toric intraocular lens implantation.

To investigate the possible effect of an implantable collamer lens (ICL) on ocular biometrics and intraocular lens (IOL) power calculation.

Effect of Implantable Collamer Lens on Anterior Segment Measurement and Intraocular Lens Power Calculation Based on IOLMaster 700 and Sirius.

To explore the utility of the recovery time (RT) after temporal contrast adaptation in primary open-angle glaucoma (POAG) visual function analysis, especially in severe and end-stage glaucoma, by the Erlanger Flicker Test (EFT).

Temporal contrast adaptation in the analysis of visual function in primary open-angle glaucoma.

This study aimed to explore the clinical significance of the combined application of palpebral margin cleaning and antibiotic eye drops in inhibiting bacterial growth in the palpebral margin and conjunctival sacs before cataract extraction.

Inhibitory effect of short-term palpebral margin cleaning with antibiotic eye drops on ocular surface flora before cataract extraction: A New Preoperative Antibacterial Method.

To investigate the possible effect of implantable collamer lens (ICL) V4c on ocular biometric measurements by a new biometer Pentacam-AXL and partial coherence interferometry (PCI)-based IOLMaster 500 and intraocular lens power calculation using fourth-generation formula.

The effect of implantable collamer Lens V4c on ocular biometric measurements and intraocular lens power calculation based on Pentacam-AXL and IOLMaster 500.

Corneal ectatic diseases are a group of corneal disorder characterized by the steepening and thinning of the cornea. Older people are not a high-risk population for corneal ectatic diseases; due to the lack of typical preoperative topographic manifestations, there is a high possibility that corneal ectasia is undetected.

Article	Year
Color discrimination by patients with different types of light-filtering intraocular lenses. Journal of cataract and refractive surgery\| PubMed ID: 20202534	2010
[Influence of 460-480 nm wavelength light at three different irradiance on retina tissue of SD rats]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology\| PubMed ID: 24021186	2013
Long-term blue light exposure induces RGC-5 cell death in vitro: involvement of mitochondria-dependent apoptosis, oxidative stress, and MAPK signaling pathways. Apoptosis : an international journal on programmed cell death\| PubMed ID: 24682673	2014
Effect of steep meridian clear corneal incisions in phacoemulsification. European journal of ophthalmology\| PubMed ID: 25655599	2015
Macular edema after cataract surgery in diabetic eyes evaluated by optical coherence tomography. International journal of ophthalmology\| PubMed ID: 26949615	2016
Evaluation of efficacy and recurrence for anti-vascular endothelial growth factor therapy in idiopathic choroidal neovascularization. BMC ophthalmology\| PubMed ID: 32192468	2020
Rotational slit-beam marking: an advanced manual corneal astigmatic marking method for toric intraocular lens implantation. International ophthalmology\| PubMed ID: 32623630	2020
Effect of Implantable Collamer Lens on Anterior Segment Measurement and Intraocular Lens Power Calculation Based on IOLMaster 700 and Sirius. Journal of ophthalmology\| PubMed ID: 34970453	2021
Temporal contrast adaptation in the analysis of visual function in primary open-angle glaucoma. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie\| PubMed ID: 35294637	2022
Inhibitory effect of short-term palpebral margin cleaning with antibiotic eye drops on ocular surface flora before cataract extraction: A New Preoperative Antibacterial Method. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih\| PubMed ID: 35435159	2022
The effect of implantable collamer Lens V4c on ocular biometric measurements and intraocular lens power calculation based on Pentacam-AXL and IOLMaster 500. BMC ophthalmology\| PubMed ID: 36335303	2022
Refractive surprise of irregular astigmatism following cataract surgery in two patients with neglected subclinical corneal ectasia: two case reports. BMC ophthalmology\| PubMed ID: 37248492	2023

Xiaoyong Chen

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