Darlene A. Dartt

Department of Ophthalmology Schepens Eye Research Institute, Harvard Medical School

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2023

Other Publications

Article	Year
Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion. FEBS letters\| PubMed ID: 8076696	1994
Alpha 1-adrenergic and cholinergic agonists activate MAPK by separate mechanisms to inhibit secretion in lacrimal gland. American journal of physiology. Cell physiology\| PubMed ID: 12388118	2003
Regulation of mucin and fluid secretion by conjunctival epithelial cells. Progress in retinal and eye research\| PubMed ID: 12433377	2002
VEGF-dependent conjunctivalization of the corneal surface. Investigative ophthalmology & visual science\| PubMed ID: 12506063	2003
Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland. Investigative ophthalmology & visual science\| PubMed ID: 12601032	2003
Role of Ca2+ and protein kinase C in cholinergic, and alpha1-adrenergic agonists and EGF stimulated mitogen-activated protein kinase activity in lacrimal gland. Advances in experimental medicine and biology\| PubMed ID: 12613906	2002
Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion. Advances in experimental medicine and biology\| PubMed ID: 12613914	2002
Role of mitogen-activated protein kinase in cholinergic stimulation of conjunctival goblet cell secretion. Advances in experimental medicine and biology\| PubMed ID: 12613923	2002
Isolation and characterization of human goblet cells in vitro: regulation of proliferation and activation of mitogen-activated protein kinase by EGF and carbachol. Advances in experimental medicine and biology\| PubMed ID: 12613924	2002
Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. American journal of physiology. Cell physiology\| PubMed ID: 12620895	2003
Isolation and characterization of cultured human conjunctival goblet cells. Investigative ophthalmology & visual science\| PubMed ID: 12766046	2003
Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells. Investigative ophthalmology & visual science\| PubMed ID: 12766054	2003
Presence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland. Investigative ophthalmology & visual science\| PubMed ID: 12882781	2003
Regulatory pathways in lacrimal gland epithelium. International review of cytology\| PubMed ID: 14713005	2003
Control of mucin production by ocular surface epithelial cells. Experimental eye research\| PubMed ID: 14729350	2004
Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion. Experimental eye research\| PubMed ID: 15106911	2004
Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Investigative ophthalmology & visual science\| PubMed ID: 15505044	2004
Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons. The EMBO journal\| PubMed ID: 15719013	2005
Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response. Experimental eye research\| PubMed ID: 15781275	2005
Nitric oxide and cGMP mediate alpha1D-adrenergic receptor-Stimulated protein secretion and p42/p44 MAPK activation in rat lacrimal gland. Investigative ophthalmology & visual science\| PubMed ID: 16043851	2005
Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells. American journal of physiology. Cell physiology\| PubMed ID: 16760267	2006
OPC-12759 increases proliferation of cultured rat conjunctival goblet cells. Cornea\| PubMed ID: 16783146	2006
Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK. Investigative ophthalmology & visual science\| PubMed ID: 16877402	2006
Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL/MpJ-Fas(lpr) mouse model of Sjögren's syndrome. Experimental eye research\| PubMed ID: 17208228	2007
Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes. The ocular surface\| PubMed ID: 17216081	2004
Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation. Investigative ophthalmology & visual science\| PubMed ID: 17389483	2007
Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland. American journal of physiology. Cell physiology\| PubMed ID: 17687004	2007
Effect of protein kinase C and Ca(2+) on p42/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells. Experimental eye research\| PubMed ID: 17919561	2007
Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation. Experimental eye research\| PubMed ID: 18155194	2008
Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells. Experimental eye research\| PubMed ID: 18295205	2008
ERK/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture. Investigative ophthalmology & visual science\| PubMed ID: 18421078	2008
Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation. Investigative ophthalmology & visual science\| PubMed ID: 18824739	2009
The aging lacrimal gland: changes in structure and function. The ocular surface\| PubMed ID: 18827949	2008
Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation. Investigative ophthalmology & visual science\| PubMed ID: 19074803	2009
Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Progress in retinal and eye research\| PubMed ID: 19376264	2009
Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland. Investigative ophthalmology & visual science\| PubMed ID: 19608535	2009
Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. The American journal of pathology\| PubMed ID: 19700744	2009
Identification of the Raf-1 signaling pathway used by cAMP to inhibit p42/p44 MAPK in rat lacrimal gland acini: role in potentiation of protein secretion. Investigative ophthalmology & visual science\| PubMed ID: 20671279	2010
Phospholipase D1, but not D2, regulates protein secretion via Rho/ROCK in a Ras/Raf-independent, MEK-dependent manner in rat lacrimal gland. Investigative ophthalmology & visual science\| PubMed ID: 21212180	2011
Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21357260	2011
Identification of P2X₃ and P2X₇ purinergic receptors activated by ATP in rat lacrimal gland. Investigative ophthalmology & visual science\| PubMed ID: 21421865	2011
Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland. Investigative ophthalmology & visual science\| PubMed ID: 21421880	2011
Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion. Investigative ophthalmology & visual science\| PubMed ID: 21685341	2011
Tear lipocalin: structure and function. The ocular surface\| PubMed ID: 21791187	2011
Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells. Investigative ophthalmology & visual science\| PubMed ID: 22039237	2011
Isolation and characterization of progenitor cells in uninjured, adult rat lacrimal gland. Investigative ophthalmology & visual science\| PubMed ID: 22427571	2012
Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion. Investigative ophthalmology & visual science\| PubMed ID: 22467574	2012
Effect of biopsy location and size on proliferative capacity of ex vivo expanded conjunctival tissue. Investigative ophthalmology & visual science\| PubMed ID: 22491407	2012
Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells. Investigative ophthalmology & visual science\| PubMed ID: 22956601	2012
Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Experimental eye research\| PubMed ID: 22975404	2012
New twists to an old story: novel concepts in the pathogenesis of allergic eye disease. Current eye research\| PubMed ID: 23281793	2013
Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. Mucosal immunology\| PubMed ID: 23462912	2013
Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells. Investigative ophthalmology & visual science\| PubMed ID: 23518767	2013
miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. Experimental eye research\| PubMed ID: 23872359	2013
Role of PKCα activation of Src, PI-3K/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells. Investigative ophthalmology & visual science\| PubMed ID: 23882690	2013
Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins. Experimental eye research\| PubMed ID: 23954166	2013
Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PloS one\| PubMed ID: 24040145	2013
Complexity of the tear film: importance in homeostasis and dysfunction during disease. Experimental eye research\| PubMed ID: 24280033	2013
Polymorphism in THBS1 gene is associated with post-refractive surgery chronic ocular surface inflammation. Ophthalmology\| PubMed ID: 24679443	2014
The impact of storage temperature on the morphology, viability, cell number and metabolism of cultured human conjunctival epithelium. Current eye research\| PubMed ID: 24750037	2015
Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation. Current opinion in allergy and clinical immunology\| PubMed ID: 25061855	2014
Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrim... Experimental eye research\| PubMed ID: 25151301	2014
Serum-free and xenobiotic-free preservation of cultured human limbal epithelial cells. PloS one\| PubMed ID: 25734654	2015
Effect of Storage Temperature on Structure and Function of Cultured Human Oral Keratinocytes. PloS one\| PubMed ID: 26052937	2015
Conjunctival Goblet Cell Function: Effect of Contact Lens Wear and Cytokines. Eye & contact lens\| PubMed ID: 26067396	2016
Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair. Current molecular biology reports\| PubMed ID: 26688786	2015
Concise Review: Comparison of Culture Membranes Used for Tissue Engineered Conjunctival Epithelial Equivalents. Journal of functional biomaterials\| PubMed ID: 26690486	2015
Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: Manifestations, incidence, and predictive factors. Journal of cataract and refractive surgery\| PubMed ID: 26796443	2015
Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes. PloS one\| PubMed ID: 27023475	2016
Lipoxin A activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion. Mucosal immunology\| PubMed ID: 27072607	2017
Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility. PloS one\| PubMed ID: 27148875	2016
Signaling Pathways of Purinergic Receptors and Their Interactions with Cholinergic and Adrenergic Pathways in the Lacrimal Gland. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 27463365	2016
Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1 mice, a model of dry eye. Experimental eye research\| PubMed ID: 27697548	2016
Lipoxin A Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells. Scientific reports\| PubMed ID: 27824117	2016
Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion. Investigative ophthalmology & visual science\| PubMed ID: 27832279	2016
Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada\| PubMed ID: 28162126	2017
Lacrimal Gland Repair Using Progenitor Cells. Stem cells translational medicine\| PubMed ID: 28170196	2017
Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics. Prostaglandins, leukotrienes, and essential fatty acids\| PubMed ID: 28237084	2017
Tissue Harvesting Site and Culture Medium Affect Attachment, Growth, and Phenotype of Ex Vivo Expanded Oral Mucosal Epithelial Cells. Scientific reports\| PubMed ID: 28386069	2017
TFOS DEWS II pain and sensation report. The ocular surface\| PubMed ID: 28736339	2017
Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets. Scientific reports\| PubMed ID: 28811665	2017
Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways. Investigative ophthalmology & visual science\| PubMed ID: 28892824	2017
Neither non-toxigenic nor commensal activates NLRP3 inflammasomes in human conjunctival goblet cells. BMJ open ophthalmology\| PubMed ID: 29354725	2017
Alteration in nerves and neurotransmitter stimulation of lacrimal gland secretion in the TSP-1 mouse model of aqueous deficiency dry eye. Mucosal immunology\| PubMed ID: 29445135	2018
Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia. The British journal of ophthalmology\| PubMed ID: 29519880	2019
Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca in cultured rat conjunctival goblet cells. Experimental eye research\| PubMed ID: 29702100	2018
The Level of Inflammatory Tear Cytokines is Elevated in Congenital Aniridia and Associated with Meibomian Gland Dysfunction. Investigative ophthalmology & visual science\| PubMed ID: 29801153	2018
Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells. Investigative ophthalmology & visual science\| PubMed ID: 30025103	2018
Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators. Scientific reports\| PubMed ID: 30111832	2018
Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort. Current eye research\| PubMed ID: 30183390	2018
Molecular layer deposition builds biocompatible substrates for epithelial cells. Journal of biomedical materials research. Part A\| PubMed ID: 30194710	2018
Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model. Mucosal immunology\| PubMed ID: 30279513	2019
Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves. International journal of molecular sciences\| PubMed ID: 30332778	2018
Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cell... Experimental eye research\| PubMed ID: 30513286	2019
Meibomian Gland Morphology Is a Sensitive Early Indicator of Meibomian Gland Dysfunction. American journal of ophthalmology\| PubMed ID: 30578784	2019
Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment. Journal of glaucoma\| PubMed ID: 30585937	2019
Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients. Current eye research\| PubMed ID: 30955380	2019
Resolvin D2 elevates cAMP to increase intracellular [Ca] and stimulate secretion from conjunctival goblet cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31013438	2019
Functional and Morphological Evaluation of Meibomian Glands in the Assessment of Meibomian Gland Dysfunction Subtype and Severity. American journal of ophthalmology\| PubMed ID: 31526799	2020
Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface. Advances in experimental medicine and biology\| PubMed ID: 31562618	2019
Diagnostic Test Efficacy of Meibomian Gland Morphology and Function. Scientific reports\| PubMed ID: 31758085	2019
Simple limbal epithelial transplantation: Current status and future perspectives. Stem cells translational medicine\| PubMed ID: 31802651	2020
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease. Scientific reports\| PubMed ID: 32218518	2020
RvE1 uses the LTB receptor BLT1 to increase [Ca] and stimulate mucin secretion in cultured rat and human conjunctival goblet cells. The ocular surface\| PubMed ID: 32361084	2020
Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca ] and secretion in conjunctival goblet cells. Journal of cellular physiology\| PubMed ID: 32510663	2021
Resolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells. The American journal of pathology\| PubMed ID: 32561135	2020
Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease. The American journal of pathology\| PubMed ID: 32679229	2020
Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture. BMJ open ophthalmology\| PubMed ID: 32995498	2020
Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients. The ocular surface\| PubMed ID: 33246035	2021
Mouse Models of Sjögren's Syndrome with Ocular Surface Disease. International journal of molecular sciences\| PubMed ID: 33266081	2020
Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases. Frontiers in immunology\| PubMed ID: 33968020	2021
The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration. The ocular surface\| PubMed ID: 34102309	2021
Biological tissues and components, and synthetic substrates for conjunctival cell transplantation. The ocular surface\| PubMed ID: 34119712	2021
Benzalkonium Chloride-Preserved Anti-Glaucomatous Eye Drops and Their Effect on Human Conjunctival Goblet Cells in vitro. Biomedicine hub\| PubMed ID: 34616748	2021
Characterisation of Gel-Forming Mucins Produced In Vivo and In Ex Vivo Conjunctival Explant Cultures. International journal of molecular sciences\| PubMed ID: 34638869	2021
The association between visual display terminal use and dry eye: a review. Acta ophthalmologica\| PubMed ID: 34697901	2022
Chambered warm moist air eyelid warming devices - a review. Acta ophthalmologica\| PubMed ID: 34750979	2022
TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial. Scientific reports\| PubMed ID: 34789807	2021
Role of the Phospholipase C Pathway and Calcium Mobilization in Oxytocin-Induced Contraction of Lacrimal Gland Myoepithelial Cells. Investigative ophthalmology & visual science\| PubMed ID: 34812841	2021
Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical prope... BMJ open ophthalmology\| PubMed ID: 34993350	2021
Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca] Increase and Mucin Secretion in Conjunctival Goblet Cells. International journal of molecular sciences\| PubMed ID: 35008563	2021
In-office thermal systems for the treatment of dry eye disease. Survey of ophthalmology\| PubMed ID: 35192836	2022
Review on the possible pathophysiological mechanisms underlying visual display terminal-associated dry eye disease. Acta ophthalmologica\| PubMed ID: 35441459	2022
Hyaluronic acid in the treatment of dry eye disease. Acta ophthalmologica\| PubMed ID: 35514082	2022
Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1. International journal of molecular sciences\| PubMed ID: 35682912	2022
Resolvin D2 uses multiple Ca -dependent signaling pathways to stimulate mucin secretion in rat and human conjunctival goblet cells. Journal of cellular physiology\| PubMed ID: 36066128	2022
Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators. Scientific reports\| PubMed ID: 36175572	2022
Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis - A review. The ocular surface\| PubMed ID: 36210626	2022
Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation. Frontiers in immunology\| PubMed ID: 36341342	2022
Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface. BMC ophthalmology\| PubMed ID: 36522696	2022
Hot towels: The bedrock of Meibomian gland dysfunction treatment - A review. Contact lens & anterior eye : the journal of the British Contact Lens Association\| PubMed ID: 36715292	2023
Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism. International journal of molecular sciences\| PubMed ID: 36901740	2023
The First Transcriptomic Atlas of the Adult Lacrimal Gland Reveals Epithelial Complexity and Identifies Novel Progenitor Cells in Mice. Cells\| PubMed ID: 37408269	2023
Anti-Inflammatory and Pro-resolving Actions of the N-Terminal Peptides Ac2-26, Ac2-12, and Ac9-25 of Annexin A1 on Conjunctival Goblet Cell Function. The American journal of pathology\| PubMed ID: 37423551	2023