Jens Christian Schwamborn

Luxembourg Centre for Systems Biomedicine, University of Luxembourg

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2023

Other Publications

Article	Year
Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain. Stem cell reports\| PubMed ID: 25241741	2014
The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs. Nucleic acids research\| PubMed ID: 25722370	2015
TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability. Scientific reports\| PubMed ID: 26307407	2015
Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia. Scientific reports\| PubMed ID: 26541394	2015
Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32. Molecular neurobiology\| PubMed ID: 27339877	2017
Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28348207	2017
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem cell reports\| PubMed ID: 28416282	2017
Parkinson's Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32. Molecular neurobiology\| PubMed ID: 28508149	2018
CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons. Stem cell research\| PubMed ID: 28826027	2017
FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling. Stem cell reports\| PubMed ID: 28988985	2017
Human induced pluripotent stem cell-derived neuronal progenitors are a suitable and effective drug discovery model for neurological mtDNA disorders. Stem cell investigation\| PubMed ID: 29359140	2017
A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification. Cell death and differentiation\| PubMed ID: 29899379	2019
Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab on a chip\| PubMed ID: 30204191	2018
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality. Stem cell reports\| PubMed ID: 30982740	2019
Automated high-throughput high-content autophagy and mitophagy analysis platform. Scientific reports\| PubMed ID: 31263238	2019
Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients. Parkinsonism & related disorders\| PubMed ID: 31621607	2019
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis. Acta neuropathologica communications\| PubMed ID: 31888773	2019
Midbrain Organoids: A New Tool to Investigate Parkinson's Disease. Frontiers in cell and developmental biology\| PubMed ID: 32509785	2020
Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease. Stem cell research\| PubMed ID: 32534166	2020
Machine learning-assisted neurotoxicity prediction in human midbrain organoids. Parkinsonism & related disorders\| PubMed ID: 32534431	2020
Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell and tissue research\| PubMed ID: 32737576	2020
Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson's disease? Neural regeneration research\| PubMed ID: 32985472	2021
Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations. NPJ Parkinson's disease\| PubMed ID: 33298969	2020
Transition metal dichalcogenides to optimize the performance of peptide-imprinted conductive polymers as electrochemical sensors. Mikrochimica acta\| PubMed ID: 34043106	2021
The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell reports\| PubMed ID: 34686322	2021
Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression. American journal of human genetics\| PubMed ID: 35077669	2022
Generation of isogenic control DJ-1-delP GC13 for the genetic Parkinson's disease-patient derived iPSC line DJ-1-delP (LCSBi008-A-1). Stem cell research\| PubMed ID: 35617842	2022
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T homeostasis during ageing. Nature metabolism\| PubMed ID: 35618940	2022
Generalising from conventional pipelines using deep learning in high-throughput screening workflows. Scientific reports\| PubMed ID: 35794231	2022
Bone Tissue and the Nervous System: What Do They Have in Common? Cells\| PubMed ID: 36611845	2022
Advanced brain organoids for neuroinflammation disease modeling. Neural regeneration research\| PubMed ID: 37488859	2024