microfluidic-model-necrotizing-enterocolitis-incorporating-human

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Necrotizing enterocolitis (NEC) is a severe and potentially fatal intestinal disease that has been difficult to study due to its complex pathogenesis, ...

University of North Carolina at Chapel Hill

Necrotizing enterocolitis (NEC) is a devastating, multifactorial disease mainly affecting the intestine of premature infants. Recent discoveries have significantly enhanced our understanding of risk factors, as well as, cellular and genetic mechanisms of this complex disease. Despite these advancements, no essential, single risk factor, nor the mechanism by which each risk factor affects NEC has been elucidated. Nonetheless, recent research indicates that maternal factors, antibiotic exposure, feeding, hypoxia, and altered gut microbiota pose a threat to the underdeveloped immunity of preterm infants. Here we review predisposing factors, status of unwarranted immune responses, and microbial pathogenesis in NEC based on currently available scientific evidence. We additionally discuss novel techniques and models used to study NEC and how this research translates from the bench to the bedside into potential treatment strategies.

Necrotizing enterocolitis: Bench to bedside approaches and advancing our understanding of disease pathogenesis.

Necrotizing enterocolitis (NEC) is a potentially fatal intestinal disease primarily affecting preterm infants. Early diagnosis of neonates with NEC is crucial to improving outcomes; however, traditional diagnostic tools remain inadequate. Biomarkers represent an opportunity to improve the speed and accuracy of diagnosis, but they are not routinely used in clinical practice.

Article	Year
Necrotizing enterocolitis: Bench to bedside approaches and advancing our understanding of disease pathogenesis. Frontiers in pediatrics\| PubMed ID: 36714655	2022
Identification of serum biomarkers for necrotizing enterocolitis using aptamer-based proteomics. Frontiers in pediatrics\| PubMed ID: 37325361	2023

Stephen Mackay

Biography

JoVE Journal Publications

Other Publications