electromyometrial-imaging-of-uterine-contractions-in-pregnant-women

Electromyometrial Imaging of Uterine Contractions in Pregnant Women

During normal pregnancy, the uterine smooth muscle, the myometrium, begins to have weak, uncoordinated contractions at late gestation to help the cervix ...

Washington University School of Medicine

Washington University

This study aims to quantify microglial activation in individuals with Alzheimer disease (AD) using the 18-kDa translocator protein (TSPO) PET imaging in the hippocampus and precuneus, the 2 AD-vulnerable regions, and to evaluate the association of baseline neuroinflammation with amyloidosis, tau, and longitudinal cognitive decline.

Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease.

This cohort study uses electromyometrial imaging to examine the underlying electrophysiological origins of human labor at the myometrium level.

Analysis of Electrophysiological Activation of the Uterus During Human Labor Contractions.

Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects' clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression.

Article	Year
Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease. Neurology(R) neuroimmunology & neuroinflammation\| PubMed ID: 35260470	2022
Analysis of Electrophysiological Activation of the Uterus During Human Labor Contractions. JAMA network open\| PubMed ID: 35653158	2022
Noninvasive electromyometrial imaging of human uterine maturation during term labor. Nature communications\| PubMed ID: 36918533	2023

Zhexian Sun

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