Gabriel C. Lander

Department of Structural and Computational Biology, Scripps Research

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2023

Other Publications

Article	Year
Exploring icosahedral virus structures with VIPER. Nature reviews. Microbiology\| PubMed ID: 16205712	2005
The structure of an infectious P22 virion shows the signal for headful DNA packaging. Science (New York, N.Y.)\| PubMed ID: 16709746	2006
Automated cryoEM data acquisition and analysis of 284742 particles of GroEL. Journal of structural biology\| PubMed ID: 16762565	2006
Polyvalent display of heme on hepatitis B virus capsid protein through coordination to hexahistidine tags. Chemistry & biology\| PubMed ID: 18482703	2008
A test-bed for optimizing high-resolution single particle reconstructions. Journal of structural biology\| PubMed ID: 18534866	2008
Assembly architecture and DNA binding of the bacteriophage P22 terminase small subunit. Journal of molecular biology\| PubMed ID: 18775728	2008
Bacteriophage lambda stabilization by auxiliary protein gpD: timing, location, and mechanism of attachment determined by cryo-EM. Structure (London, England : 1993)\| PubMed ID: 18786402	2008
Appion: an integrated, database-driven pipeline to facilitate EM image processing. Journal of structural biology\| PubMed ID: 19263523	2009
Ab initio maximum likelihood reconstruction from cryo electron microscopy images of an infectious virion of the tailed bacteriophage P22 and maximum likelihood versions of Fourier Shell Corr... Journal of structural biology\| PubMed ID: 19457456	2009
Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase. The Journal of general virology\| PubMed ID: 19474243	2009
The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit. Structure (London, England : 1993)\| PubMed ID: 19523897	2009
A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy. Journal of structural biology\| PubMed ID: 20018246	2010
An automated procedure for detecting protein folds from sub-nanometer resolution electron density. Journal of structural biology\| PubMed ID: 20026407	2010
Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20660783	2010
Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22. Structure (London, England : 1993)\| PubMed ID: 21439834	2011
Capsomer dynamics and stabilization in the T = 12 marine bacteriophage SIO-2 and its procapsid studied by CryoEM. Structure (London, England : 1993)\| PubMed ID: 22405008	2012
DNA bending-induced phase transition of encapsidated genome in phage λ. Nucleic acids research\| PubMed ID: 23449219	2013
Solid-to-fluid-like DNA transition in viruses facilitates infection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25271319	2014
The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits. Journal of molecular biology\| PubMed ID: 25659908	2015
Structural organization of the dynein-dynactin complex bound to microtubules. Nature structural & molecular biology\| PubMed ID: 25751425	2015
Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. Cell\| PubMed ID: 25959773	2015
Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22. Journal of molecular biology\| PubMed ID: 26301600	2015
Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome. Nature structural & molecular biology\| PubMed ID: 26301997	2015
Site-specific labeling of proteins for electron microscopy. Journal of structural biology\| PubMed ID: 26409249	2015
Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex. Biophysical journal\| PubMed ID: 26488657	2015
Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition. eLife\| PubMed ID: 26744777	2016
Cryo-electron microscopy structure of the TRPV2 ion channel. Nature structural & molecular biology\| PubMed ID: 26779611	2016
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature\| PubMed ID: 27338790	2016
Isolation of yeast complex IV in native lipid nanodiscs. Biochimica et biophysica acta\| PubMed ID: 27620332	2016
What's the Key to Unlocking the Proteasome's Gate? Structure (London, England : 1993)\| PubMed ID: 27926830	2016
Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Cell\| PubMed ID: 28340349	2017
Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28438998	2017
The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. The EMBO journal\| PubMed ID: 28655754	2017
Achieving better-than-3-Å resolution by single-particle cryo-EM at 200 keV. Nature methods\| PubMed ID: 28991891	2017
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Nature\| PubMed ID: 29019979	2017
Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. Science (New York, N.Y.)\| PubMed ID: 29097521	2017
Structure of the cold- and menthol-sensing ion channel TRPM8. Science (New York, N.Y.)\| PubMed ID: 29217583	2018
The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading. Nature communications\| PubMed ID: 29321502	2018
Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. Nature structural & molecular biology\| PubMed ID: 29416113	2018
Author Correction: Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. Nature structural & molecular biology\| PubMed ID: 29476122	2018
Exploring applications of crowdsourcing to cryo-EM. Journal of structural biology\| PubMed ID: 29486249	2018
Cryo-EM structure of a mitochondrial calcium uniporter. Science (New York, N.Y.)\| PubMed ID: 29954988	2018
Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30185561	2018
Substrate-engaged 26 proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation. Science (New York, N.Y.)\| PubMed ID: 30309908	2018
Conformational ensemble of the human TRPV3 ion channel. Nature communications\| PubMed ID: 30429472	2018
A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality. Structure (London, England : 1993)\| PubMed ID: 30449687	2019
The rod-shaped ATG2A-WIPI4 complex tethers membranes in vitro. Contact (Thousand Oaks (Ventura County, Calif.))\| PubMed ID: 30766969	2018
High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM. Nature communications\| PubMed ID: 30833564	2019
Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry. Molecular cell\| PubMed ID: 30872121	2019
Setting the dynein motor in motion: New insights from electron tomography. The Journal of biological chemistry\| PubMed ID: 31285262	2019
An allosteric network in spastin couples multiple activities required for microtubule severing. Nature structural & molecular biology\| PubMed ID: 31285604	2019
Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease. Molecular cell\| PubMed ID: 31327635	2019
Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel. Nature communications\| PubMed ID: 31431622	2019
Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM. Journal of microscopy\| PubMed ID: 31553060	2019
The molecular principles governing the activity and functional diversity of AAA+ proteins. Nature reviews. Molecular cell biology\| PubMed ID: 31754261	2020
Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation. eLife\| PubMed ID: 31778111	2019
Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. eLife\| PubMed ID: 32101164	2020
Author Correction: An allosteric network in spastin couples multiple activities required for microtubule severing. Nature structural & molecular biology\| PubMed ID: 32203494	2020
AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex. Nature communications\| PubMed ID: 32483187	2020
Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Science advances\| PubMed ID: 32490208	2020
How low can we go? Structure determination of small biological complexes using single-particle cryo-EM. Current opinion in structural biology\| PubMed ID: 32599507	2020
Sub-2 Angstrom resolution structure determination using single-particle cryo-EM at 200 keV. Journal of structural biology: X\| PubMed ID: 32647824	2020
Present and Emerging Methodologies in Cryo-EM Single-Particle Analysis. Biophysical journal\| PubMed ID: 32919493	2020
A guided approach for subtomogram averaging of challenging macromolecular assemblies. Journal of structural biology: X\| PubMed ID: 33319208	2020
Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nature communications\| PubMed ID: 34050165	2021
Structural basis for piRNA targeting. Nature\| PubMed ID: 34471284	2021
Conquer by cryo-EM without physically dividing. Biochemical Society transactions\| PubMed ID: 34709401	2021
A case for glycerol as an acceptable additive for single-particle cryoEM samples. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34981768	2022
Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. The Journal of biological chemistry\| PubMed ID: 35143841	2022
Allosteric differences dictate GroEL complementation of E. coli. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 35199390	2022
The YΦ motif defines the structure-activity relationships of human 20S proteasome activators. Nature communications\| PubMed ID: 35264557	2022
Coupling of distant ATPase domains in the circadian clock protein KaiC. Nature structural & molecular biology\| PubMed ID: 35864165	2022
Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA. Nature communications\| PubMed ID: 36042193	2022
Structure of the hepatitis C virus E1E2 glycoprotein complex. Science (New York, N.Y.)\| PubMed ID: 36264808	2022
Molecular glue CELMoD compounds are regulators of cereblon conformation. Science (New York, N.Y.)\| PubMed ID: 36378961	2022
Succinylation of a KEAP1 sensor lysine promotes NRF2 activation. bioRxiv : the preprint server for biology\| PubMed ID: 37215033	2023
DELE1 oligomerization promotes integrated stress response activation. Nature structural & molecular biology\| PubMed ID: 37550454	2023
Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition. Nature communications\| PubMed ID: 37558671	2023
Succinylation of a KEAP1 sensor lysine promotes NRF2 activation. Cell chemical biology\| PubMed ID: 37619563	2023