Christopher C. W. Hughes

Molecular Biology and Biochemistry, University of California, Irvine

Affiliated withUniversity of California, Irvine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2023

Other Publications

Article	Year
Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvascular research\| PubMed ID: 12453432	2002
VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 14691306	2003
Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15774577	2005
HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes. Biochemical and biophysical research communications\| PubMed ID: 16782059	2006
Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity\| PubMed ID: 17306568	2007
Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation. Tissue engineering\| PubMed ID: 17518656	2006
Endothelial-stromal interactions in angiogenesis. Current opinion in hematology\| PubMed ID: 18391786	2008
An optimized three-dimensional in vitro model for the analysis of angiogenesis. Methods in enzymology\| PubMed ID: 18772011	2008
Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue engineering. Part A\| PubMed ID: 18976155	2009
TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. Gene\| PubMed ID: 19393188	2009
Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PloS one\| PubMed ID: 19924227	2009
BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II. Angiogenesis\| PubMed ID: 22622516	2012
Macrophages and angiogenesis: a role for Wnt signaling. Vascular cell\| PubMed ID: 22938389	2012
Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23288153	2013
Angiogenic sprouting is regulated by endothelial cell expression of Slug. Journal of cell science\| PubMed ID: 24554431	2014
Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24603679	2014
A role for partial endothelial-mesenchymal transitions in angiogenesis? Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25425619	2015
Executive summary of the 11th HHT international scientific conference. Angiogenesis\| PubMed ID: 26391603	2015
Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels. Lab on a chip\| PubMed ID: 26616908	2016
mTORC2 mediates CXCL12-induced angiogenesis. Angiogenesis\| PubMed ID: 27106789	2016
Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials\| PubMed ID: 27914984	2017
A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications. Lab on a chip\| PubMed ID: 28092382	2017
3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28634954	2017
Executive summary of the 12th HHT international scientific conference. Angiogenesis\| PubMed ID: 29147802	2018
Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia. Angiogenesis\| PubMed ID: 30191360	2019
Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Stem cell reports\| PubMed ID: 30745035	2019
Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis. Nature communications\| PubMed ID: 33106502	2020
An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy. Lab on a chip\| PubMed ID: 33605955	2021
The vascular niche in next generation microphysiological systems. Lab on a chip\| PubMed ID: 34396383	2021
Correction: The vascular niche in next generation microphysiological systems. Lab on a chip\| PubMed ID: 34472547	2021
Adoptive T-Cell Therapy in Advanced Colorectal Cancer: A Systematic Review. The oncologist\| PubMed ID: 35274719	2022
Organotypic stromal cells impact endothelial cell transcriptome in 3D microvessel networks. Scientific reports\| PubMed ID: 36443378	2022
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 36481562	2023