transoral-robotic-total-thyroidectomy-bilateral-central-regional

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Currently, the common approaches to thyroid surgery include conventional thyroidectomy, bilateral axillo-breast, axillary, retroauricular, and oral ...

Army Medical University (Third Military Medical University)

: In Chinese women, breast and colorectal cancers are highly prevalent. In the early stage, the primary treatment for these cancers is surgical resection. However, many patients develop a metastatic recurrence. Thus, tools that help estimate the risk of recurrence are critical. Although synchronous breast and rectal cancer is uncommon, estimating recurrence risk is even more challenging in patients with two histologically distinct malignancies. : Next generation sequencing (NGS) allows the comprehensive detection of simultaneous genome abnormalities. NGS-based circulating tumor DNA (ctDNA) profiling is a new molecular technique that has demonstrated great potential in the detection and differential diagnosis of cancer relapse. : We present a 43-year-old female patient with synchronous breast and rectal cancer that was surgically removed 2 years prior. During regular follow-up, elevated carcinoembryonic antigen (CEA) levels were detected. ctDNA profiling revealed multiple somatic mutations that were identical to those found in rectal cancer samples. Thus, we suspected relapse of rectal cancer. Positron emission tomography-computed tomography (PET-CT) and pathogenic analysis confirmed lung metastasis of rectal cancer. : This case demonstrated the utility of ctDNA profiling in the detection and differential diagnosis of cancer relapse in a patient with synchronous breast and rectal cancer.

Detection and differential diagnosis of cancer relapse using circulating tumor DNA profiling in a patient with synchronous breast and rectal cancer.

Serum calcitonin is often elevated in medulla thyroid carcinoma (MTC) and thus serves as an indicator of primary and recurrent disease. However, there are MTC patients with normal Serum calcitonin and the underlying mechanisms are largely unknown.

Genetic analysis of a hereditary medullary thyroid carcinoma case with normal preoperative serum calcitonin levels.

DNA methylation detection is indispensable for the diagnosis and prognosis of various diseases including malignancies. Hence, it is crucial to develop a simple, sensitive, and specific detection strategy.

A novel fluorescent biosensor based on dendritic DNA nanostructure in combination with ligase reaction for ultrasensitive detection of DNA methylation.

Emerging evidence suggested that  () was associated with immune activity and stem cell regulation in breast cancer. Whereas, the roles and molecular mechanisms of  in oncogenesis remain unclear.  expression was significantly diminished in breast cancer which was associated with promoter CpG methylation but not mutation. Ectopic over-expression of  suppressed breast cancer cell proliferation and colony formation and promoted apoptosis , while knockdown of  resulted in an opposite phenotype. Anti-proliferation effect of  was verified . Bioinformatic analysis of public databases and transcriptome sequencing both showed that  could enhance apoptosis through transcriptional regulation of the / pathway. ChIP and luciferase report assays demonstrated that ZNF831 could directly bind to one specific region of  promoter and induce the transcriptional inhibition of . As a result, the attenuation of  led to a restraint of the transcription of  and thus accelerated the apoptotic progression. Augmentation of  diminished the apoptosis-promoting effect of  in breast cancer cell lines. Furthermore,  could ameliorate the anti-proliferation effect of capecitabine and gemcitabine in breast cancer cell lines. Our findings demonstrate for the first time that  is a novel transcriptional suppressor through inhibiting the expression of /2 and promoting the apoptosis process in breast cancer, suggesting  as a novel biomarker and potential therapeutic target for breast cancer patients.

Article	Year
Detection and differential diagnosis of cancer relapse using circulating tumor DNA profiling in a patient with synchronous breast and rectal cancer. Cancer biology & therapy\| PubMed ID: 30257133	2019
Genetic analysis of a hereditary medullary thyroid carcinoma case with normal preoperative serum calcitonin levels. Pathology, research and practice\| PubMed ID: 31409511	2019
A novel fluorescent biosensor based on dendritic DNA nanostructure in combination with ligase reaction for ultrasensitive detection of DNA methylation. Journal of nanobiotechnology\| PubMed ID: 31812164	2019
promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the signaling pathway. Genes & diseases\| PubMed ID: 37588209	2024

Shu Zhang

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