immunofluorescent-labeling-nasal-mucosa-tissue-sections-allergic

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats <em>via</em> Multicolor Immunoassay

Allergic rhinitis (AR) is a chronic, non-infectious inflammatory disease of the nasal mucosa, primarily mediated by specific immunoglobulin E (IgE), ...

copd-associated-panoptosis-genes-predict-prognosis-chemotherapy

COPD-Associated PANoptosis Genes Predict Prognosis and Chemotherapy Sensitivity in Lung Squamous Cell Carcinoma

Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease that increases the risk of lung squamous cell carcinoma (LUSC). ...

hospital of chengdu university of traditional chinese medicine

Nanjing University of Chinese Medicine

 Although the use of dexamethasone as an adjunct agent is associated with alleviating pain and prolonging analgesic duration in local wound infiltration (LWI), efficacy and safety of dexamethasone infiltration have not been fully explored. The study sought to quantify the pooled effects of dexamethasone infiltration on postoperative pain, analgesic consumption, and side effects through a review of randomized controlled trials (RCTs).  RCTs comparing dexamethasone + LWI with LWI alone were retrieved from seven electronic databases. Co-primary outcomes were rest pain scores and cumulative morphine equivalent consumption within 24 h postoperatively. The study followed PRISMA, AMSTAR, and the Cochrane Collaboration.  Eight trials comprising 609 patients were included in the final analysis. Results indicated that dexamethasone infiltration effects were only statistical but not clinically significant at individual time points of rest pain and patient satisfaction scores. Notably, the effect of dexamethasone infiltration therapy on other pain-related parameters, including cumulative morphine consumption (mean difference, -9.05 mg; 95% CI: -22.47 to 4.37), was not significantly different compared with the control group. Analysis showed no significant differences in safety indicators between the two groups. The overall quality of evidence was high to very low.  Although statistically significant effects of dexamethasone infiltration were observed for some outcomes of postoperative wound pain, the overall benefits were below the expected minimal clinically important difference.  In summary, the current evidence does not support routine clinical use of dexamethasone in LWI. However, further studies should explore the clinical value of preemptive analgesia and safety of a combination of dexamethasone with ropivacaine for LWI.

ArticleTotal : 2	Year
Publication title Cited by 1	2023
Publication title	2026

Yucheng Hu

Biography

JoVE Journal Publications

Other Publications