immunofluorescent-labeling-nasal-mucosa-tissue-sections-allergic

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats <em>via</em> Multicolor Immunoassay

Allergic rhinitis (AR) is a chronic, non-infectious inflammatory disease of the nasal mucosa, primarily mediated by specific immunoglobulin E (IgE), ...

hospital of chengdu university of traditional chinese medicine

Benign fibrous histiocytoma (BFH) is a mesenchymal tumor composed of fibroblasts and histiocytes, which normally occurs in the bone tissue and/or the skin of the limbs. BFH of the nasal septum is rare worldwide.

38-year-old woman with nasal congestion: A rare case of septum-originated benign fibrous histiocytoma.

Assessing the effectiveness and safety of traditional Chinese medicine (TCM) for symptoms of upper respiratory tract of coronavirus disease 2019 is the main purpose of this systematic review protocol.

Traditional Chinese medicine for symptoms of upper respiratory tract of COVID-19: A protocol for systematic review and meta-analysis.

Thymic stromal lymphopoietin (TSLP) is an important factor that affects the development of allergic diseases. Single nucleotide polymorphism of TSLP is closely related to the susceptibility, course and severity of allergic diseases. Following exposure to allergens, multiple signalling pathways in epithelial cells mediate TSLP expression and induce an immune cascade. TSLP affects epithelial physical barrier damage by inhibiting the expression of tight junctions, adhesion junctions and desmosomes and destroying the lipid layer. Two isomers of TSLP have antibacterial properties and can enhance the defence ability of the skin and mucosa. Moreover, TSLP plays a protective role by up-regulating the expression of tight junction proteins during early inflammation. In allergic diseases, TSLP participates in the proliferation and differentiation of various immune cells through the TSLP receptor pathway and releases pro-inflammatory and chemokine factors, thus mediating immune inflammation. Furthermore, TSLP is involved in airway remodelling in respiratory allergies by inducing fibrocyte migration and recruitment and promoting epithelial-mesenchymal transformation. Therefore, inhibition of TSLP may be a potential target for the treatment of allergic diseases. Research on biological agents targeted by TSLP is warranted for the treatment of allergic diseases in the future.

[Progress of epithelial-derived thymic stromal lymphopoietin (TSLP) in allergic diseases: An update].

Nasal septal suturing is a commonly used alternative treatment to nasal packing after septoplasty. Besides alleviating postoperative discomfort, extensive studies have shown that nasal septal suturing is more effective than nasal packing. However, its clinical benefits remain controversial.

Is nasal septal suturing an alternative technique to nasal packing?: A protocol for systematic review and meta-analysis.

The herba Houttuynia cordata Thunb. (HC) has anti-inflammatory, antibacterial and antiviral effects. Through nasal irrigation, the related preparation of HC is beneficial for treating rhinosinusitis or promoting recovery after an endoscopic sinus surgery. However, it remains controversial whether nasal irrigation with HC preparation can provide evidence-based clinical benefits for rhinosinusitis patients.

Effects of houttuynia cordata thunb. on rhinosinusitis by nasal irrigation: A protocol for systematic review and meta-analysis.

Allergic rhinitis (AR) is a non-infectious chronic nasal mucosal disease mediated mainly by IgE, which affects 40% of the global population and has a recurrence rate of more than 50%. The modified Yupingfeng formula (MYPFF) is widely used in the treatment of allergic rhinitis in China. However, there is no evidence-based medical evidence for the efficacy and safety of MYPFF in the treatment of allergic rhinitis.

Efficacy and safety of modified Yupingfeng formula in treating allergic rhinitis: A protocol for systematic review and meta analysis.

Allergic rhinitis (AR) is one of the most common atopic disorders, which seriously affects patients' quality of life. Yupingfeng (YPF) Power is a traditional Chinese herb formula, and its oral dosage form has been widely used for the treatment of AR in Asian countries. In this study, we investigated the effects of YPF nasal drops on ovalbumin (OVA) sensitized/stimulated allergic rhinitis in rats. A Sprague-Dawley (SD) rat model of OVA-induced AR was established and then treated with three doses of YPF nasal drops. Besides, histopathological features, eosinophil cationic protein (ECP) in the nasal mucosa, and expression of type 1 helper T (Th1)/type 2 helper T (Th2)-related cytokines in serum were analyzed. The results showed that YPF nasal drops alleviated the injury of nasal mucosal epithelial structure, promoted the recovery of ciliary morphology and function and reduced interstitial edema and inflammatory cell infiltration to some extent. Moreover, YPF nasal drops regulated imbalance in Th1/Th2 cells caused by AR via regulating downward the expression of interleukin 4 (IL-4) and adjusting upward the expression of interferon-γ (INF-γ), and interleukin 12 (IL-12). Furthermore, it inhibited the expression of ECP in nasal epithelial eosinophil-specific granules. The findings of this study provided a new perspective for the treatment of AR with YPF nasal drops based on Traditional Chinese Medicine.

Effects of Yupingfeng nasal drops on serum cytokines, histopathology and eosinophil cationic protein in nasal mucosa of rats with allergic rhinitis.

Recurrent episode of allergic rhinitis (AR) is one of the leading illnesses that affects patients. However, there is little research evidence to support pharmacotherapy for AR recurrence. Therefore, this study was designed to explore the efficacy of pharmacotherapy in the control of the recurrence of AR.

Efficacy and Safety of Modified Yupingfeng Nasal Spray in Controlling the Recurrence of Persistent and Moderate-Severe Allergic Rhinitis: Study Protocol for a Multicenter, Open-Label, Randomized, and Parallel-Arm Trial.

Corticosteroid has been a mainstay of chronic rhinosinusitis with nasal polyps (CRSwNP) medical therapy. While endoscopic sinus surgery (ESS) will be performed when patients had failed to respond to maximal medical therapy. Many studies shown that several corticosteroids of interventions (e.g., nasal spray, oral, atomization/nebulization, nasal irrigation, direct infiltration, and steroid-eluting stent, etc) have each demonstrated significant efficacy compared with placebo or no corticosteroids intervention except intranasal corticosteroids for the treatment of CRSwNP after ESS. The aim of this systematic review and network meta-analysis is to answer the following question: which 1 is the best corticosteroid of intervention for CRSwNP patients after ESS?

The efficacy and safety of several interventions of corticosteroids for CRSwNP patients after endoscope sinus surgery: A protocol for systematic review and network meta-analysis.

Allergic rhinitis (AR) is considered to be 1 of the most difficult diseases to treat globally. It has a serious impact on the quality of life and social economy of patients and has become an important global health problem. Several drugs have been recommended to treat AR, but their effectiveness and mechanism of action in these patients remain unclear. The purpose of this study will be to compare the efficacy and mechanism of action of 2 drugs for the treatment of AR (moderate to severe): a Dermatophagoides Farinae Drops Sublingual Immunotherapy and a Momethasone Furoate nasal spray as an adjunct to the treatment of subjects with AR.

Observation on the efficacy of sublingual immunotherapy with dust mite allergen for perennial allergic rhinitis and the mechanism of action on ILCs with ILC1s and ILC2s and ILC3s.

Chronic rhinosinusitis (CRS) can be seen in people of all ages. CRS heavily affects the quality of a patient's daily life and also causes tremendous economic burdens on patients' families and society. The prevalence of CRS in different countries varies and no systematic review of the prevalence of CRS among Chinese has been published previously. The objective of this systematic review and meta-analysis is to determine the prevalence of CRS among Chinese and to explore the main risk factors of CRS among Chinese.

Prevalence and risk factors of chronic rhinosinusitis among Chinese: A systematic review and meta-analysis.

As the first line of defense against risk factors, the nasal epithelial barrier maintains homeostasis in nasal mucosa. The composition of the epithelial barrier contains physical, chemical, immune, and microbiological barriers. Together, these barriers form the nasal defense against irritations. Risk factors from both internal and external environments can disrupt them. External risk factors contain allergens containing proteases, bacteria, virus, particulate matter, diesel exhaust particles, and cigarette smoke. In the meantime, inflammatory cytokines also increase the load on the barrier. Taking into account the role of the epithelial barrier in the nasal mucosa, some studies focus on the treatment of allergic rhinitis (AR) and chronic rhinosinusitis (CRS) by restoring the epithelial barrier, and some progress has been made. Among the therapeutic approaches, histone deacetylase (HDAC) inhibitor and steroid corticosteroids are considered two of the more studied categories, and their roles in repairing barriers have been demonstrated in AR and CRS. The underlying mechanism of HDAC inhibitor may be related to the transcription factor p63. And the protection of corticosteroids may be associated with the allergic disease susceptibility gene, protocadherin-1. Notably, manipulation of the microbiological barrier also has a positive effect on AR and CRS. Lactococcus and probiotics are two categories that are worth being explored continuously. We here review and discuss the compositions and risk factors of the nasal epithelial barrier. Furthermore, some novel and promising approaches to restore the defective barrier in nasal allergic diseases were mentioned.

Epithelial Barrier in the Nasal Mucosa, Related Risk Factors and Diseases.

Pleomorphic adenoma is a common benign tumor of large and small salivary glands. It mainly occurs in the parotid gland, followed by the submandibular gland, sublingual gland and small salivary gland in the oral cavity. It is very rare in the nasal septum.

Article	Year
38-year-old woman with nasal congestion: A rare case of septum-originated benign fibrous histiocytoma. Medicine\| PubMed ID: 31169683	2019
Traditional Chinese medicine for symptoms of upper respiratory tract of COVID-19: A protocol for systematic review and meta-analysis. Medicine\| PubMed ID: 32791725	2020
[Progress of epithelial-derived thymic stromal lymphopoietin (TSLP) in allergic diseases: An update]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology\| PubMed ID: 32967769	2020
Is nasal septal suturing an alternative technique to nasal packing?: A protocol for systematic review and meta-analysis. Medicine\| PubMed ID: 33327302	2020
Effects of houttuynia cordata thunb. on rhinosinusitis by nasal irrigation: A protocol for systematic review and meta-analysis. Medicine\| PubMed ID: 33371097	2020
Efficacy and safety of modified Yupingfeng formula in treating allergic rhinitis: A protocol for systematic review and meta analysis. Medicine\| PubMed ID: 33371114	2020
Effects of Yupingfeng nasal drops on serum cytokines, histopathology and eosinophil cationic protein in nasal mucosa of rats with allergic rhinitis. Pakistan journal of pharmaceutical sciences\| PubMed ID: 34799307	2021
Efficacy and Safety of Modified Yupingfeng Nasal Spray in Controlling the Recurrence of Persistent and Moderate-Severe Allergic Rhinitis: Study Protocol for a Multicenter, Open-Label, Random... Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 35990824	2022
The efficacy and safety of several interventions of corticosteroids for CRSwNP patients after endoscope sinus surgery: A protocol for systematic review and network meta-analysis. Medicine\| PubMed ID: 36401414	2022
Observation on the efficacy of sublingual immunotherapy with dust mite allergen for perennial allergic rhinitis and the mechanism of action on ILCs with ILC1s and ILC2s and ILC3s. Medicine\| PubMed ID: 36482599	2022
Prevalence and risk factors of chronic rhinosinusitis among Chinese: A systematic review and meta-analysis. Frontiers in public health\| PubMed ID: 36699933	2022
Epithelial Barrier in the Nasal Mucosa, Related Risk Factors and Diseases. International archives of allergy and immunology\| PubMed ID: 36724763	2023
Pleomorphic Adenoma of Nasal Septum a Case Report. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India\| PubMed ID: 37206715	2023

Li Tian

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