Marcelo Cypel

Marcelo Cypel

Toronto General Hospital Research Institute, University Health Network

Affiliated withUniversity Health NetworkUniversity of Toronto

Research Area

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JoVE Journal Publications

ArticleTotal : 1
Year
Establishment of an <em>Ex Vivo</em> Lung Perfusion Rat Model for Translational Insights in Lung Transplantation
Publication title

Cited by 5

2023

Other Publications

Article
Year
Anti-human tissue factor antibody ameliorated intestinal ischemia reperfusion-induced acute lung injury in human tissue factor knock-in mice.

PloS one| PubMed ID: 18231608

2008
Technique for prolonged normothermic ex vivo lung perfusion.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 19059112

2008
Activated protein C in ischemia-reperfusion injury after experimental lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 19782612

2009
2010
Functional repair of human donor lungs by IL-10 gene therapy.

Science translational medicine| PubMed ID: 20368171

2009
Transcriptional signatures in donor lungs from donation after cardiac death vs after brain death: a functional pathway analysis.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 21093300

2011
Increased levels of interleukin-1β and tumor necrosis factor-α in donor lungs rejected for transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 21237675

2011
2011
2012
Expansion of the donor lung pool: use of lungs from smokers.

Lancet (London, England)| PubMed ID: 22647757

2012
Experience with the first 50 ex vivo lung perfusions in clinical transplantation.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 22944089

2012
Physiologic assessment of the ex vivo donor lung for transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 22975103

2012
2013
Advances in lung preservation.

The Surgical clinics of North America| PubMed ID: 24206857

2013
Modified in vivo lung perfusion allows for prolonged perfusion without acute lung injury.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 24290703

2014
Long-term outcome after en bloc resection of non-small-cell lung cancer invading the pulmonary sulcus and spine.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer| PubMed ID: 24389435

2013
Extracorporeal life support for adults with severe acute respiratory failure.

The Lancet. Respiratory medicine| PubMed ID: 24503270

2014
Low invasive in vivo tissue sampling for monitoring biomarkers and drugs during surgery.

Laboratory investigation; a journal of technical methods and pathology| PubMed ID: 24687119

2014
2014
Ex vivo lung perfusion.

Journal of thoracic disease| PubMed ID: 25132972

2014
2015
Functional outcomes and quality of life after normothermic ex vivo lung perfusion lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 25476845

2015
Neoadjuvant chemoradiation and surgery improves survival outcomes compared with definitive chemoradiation in the treatment of stage IIIA N2 non-small-cell lung cancer.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery| PubMed ID: 25567960

2015
2015
The role of the endothelin-1 pathway as a biomarker for donor lung assessment in clinical ex vivo lung perfusion.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 25907141

2015
2015
2015
Low-dose computed tomography volumetry for subtyping chronic lung allograft dysfunction.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 26342441

2016
Successful lung transplantation from a donation after cardiocirculatory death donor taking more than 120 minutes to cardiac arrest after withdrawal of life support therapies.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 26525404

2016
2015
2015
2016
Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 26787621

2016
2016
The RECOVER Program: Disability Risk Groups and 1-Year Outcome after 7 or More Days of Mechanical Ventilation.

American journal of respiratory and critical care medicine| PubMed ID: 26974173

2016
Human α1-antitrypsin improves early post-transplant lung function: Pre-clinical studies in a pig lung transplant model.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 27095003

2016
One-Year Outcomes in Caregivers of Critically Ill Patients.

The New England journal of medicine| PubMed ID: 27168433

2016
Mesenchymal stem cell treatment is associated with decreased perfusate concentration of interleukin-8 during ex vivo perfusion of donor lungs after 18-hour preservation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 27444694

2016
2017
2017
2017
Bilateral pneumonectomy to treat uncontrolled sepsis in a patient awaiting lung transplantation.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 28017368

2017
Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 28041954

2017
2017
2017
High Risk for Thoracotomy but not Thoracoscopic Lobectomy.

The Annals of thoracic surgery| PubMed ID: 28262299

2017
Cost-effectiveness of mediastinal lymph node staging in non-small cell lung cancer.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 28283236

2017
2017
Higher M30 and high mobility group box 1 protein levels in ex vivo lung perfusate are associated with primary graft dysfunction after human lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 28689646

2017
Extracorporeal support in airway surgery.

Journal of thoracic disease| PubMed ID: 28840012

2017
2017
α-Anti-trypsin improves function of porcine donor lungs during ex-vivo lung perfusion.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 29153638

2018
2018
2018
Lung in a Box: Ex Vivo Lung Transplantation.

Journal of cardiothoracic and vascular anesthesia| PubMed ID: 29449154

2018
2018
2018
2018
2018
2018
2018
Inhibition of regulated necrosis attenuates receptor-interacting protein kinase 1-mediated ischemia-reperfusion injury after lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 29907500

2018
Introducing the concept of semielective lung transplantation through the use of ex vivo lung perfusion.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 29961586

2018
Pig lung transplant survival model.

Nature protocols| PubMed ID: 30072720

2018
2019
Commentary: To die or not to die-rescuing lung cells from ischemia-reperfusion injury.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 33618878

2022
Spectrum of chronic lung allograft pathology in a mouse minor-mismatched orthotopic lung transplant model.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 30378739

2019
2019
2019
2019
2019
Donor prone positioning protects lungs from injury during warm ischemia.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 30887696

2019
2019
Ex-vivo lung perfusion and ventilation: where to from here?

Current opinion in organ transplantation| PubMed ID: 31090639

2019
2019
Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 31474491

2019
Drug-resistant cytomegalovirus infection after lung transplantation: Incidence, characteristics, and clinical outcomes.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 31570289

2019
Bilateral Lobar Transplants Using One Donor for Two Small-Sized Recipients.

The Annals of thoracic surgery| PubMed ID: 31586617

2020
2019
2020
2020
2020
Commentary: Use of hepatitis C virus viremic donors should be the standard of care.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 31987611

2020
Initial lung transplantation experience with uncontrolled donation after cardiac death in North America.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 31995660

2020
2020
Airway Oscillometry Detects Spirometric-Silent Episodes of Acute Cellular Rejection.

American journal of respiratory and critical care medicine| PubMed ID: 32135068

2020
2020
An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 32334946

2020
A model to assess acute and delayed lung toxicity of oxaliplatin during in vivo lung perfusion.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 32354628

2021
2020
Immunosuppressive Therapy in Lung Transplantation.

Current pharmaceutical design| PubMed ID: 32600225

2020
2020
Deceased-donor lobar lung transplant: A successful strategy for small-sized recipients.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 32723591

2021
Impact of donor time to cardiac arrest in lung donation after circulatory death.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 32747131

2021
International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 32773322

2020
Lung donation after medical assistance in dying at home.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 32803817

2021
When to consider lung transplantation for COVID-19.

The Lancet. Respiratory medicine| PubMed ID: 32857989

2020
Ex vivo perfusion in lung transplantation and removal of HCV: the next level.

Transplant international : official journal of the European Society for Organ Transplantation| PubMed ID: 32888320

2020
2021
2020
2020
Strategies to prolong homeostasis of ex vivo perfused lungs.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 32958268

2021
Ex vivo lung perfusion for donor lung assessment and repair: a review of translational interspecies models.

American journal of physiology. Lung cellular and molecular physiology| PubMed ID: 32996780

2020
2020
2020
2021
Ventilation parameters and early graft function in double lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 33144029

2021
Donor ventilation parameters as predictors for length of mechanical ventilation after lung transplantation: Results of a prospective multicenter study.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 33246712

2021
2022
Commentary: Bruised donor lungs-they may not be pretty, but they will still work.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 33500129

2022
Successful lung transplantation from lungs procured 12 hours after withdrawal of life-sustaining therapy: Changing the paradigm of controlled DCD donors?

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 33602628

2021
2021
A call to routinely test lower respiratory tract samples for SARS-CoV-2 in lung donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 33756058

2021
Prediction of donor related lung injury in clinical lung transplantation using a validated ex vivo lung perfusion inflammation score.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 33781664

2021
Use of metabolomics to identify strategies to improve and prolong ex vivo lung perfusion for lung transplants.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 33849769

2021
Predicting donor lung acceptance for transplant during ex vivo lung perfusion: The EX vivo lung PerfusIon pREdiction (EXPIRE).

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 33872459

2021
Pushing the Envelope for Donor Lungs.

Seminars in respiratory and critical care medicine| PubMed ID: 34030199

2021
2021
An Ingenious Approach for Lobar Lung Transplantation.

The Annals of thoracic surgery| PubMed ID: 34052218

2022
Long-term outcomes of sensitized lung transplant recipients after peri-operative desensitization.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 34058795

2021
2021
Surfactant therapy in lung transplantation: A systematic review and meta-analysis.

Transplantation reviews (Orlando, Fla.)| PubMed ID: 34224988

2021
Lung transplant recipient attitudes and beliefs on accepting an organ that is positive for hepatitis C virus.

Transplant infectious disease : an official journal of the Transplantation Society| PubMed ID: 34228382

2021
2022
2021
Lung transplantation for acute COVID-19: the Toronto Lung Transplant Program experience.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne| PubMed ID: 34580142

2021
2021
2021
Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 34802874

2022
[Not Available].

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne| PubMed ID: 34810168

2021
2022
lung perfusion.

Journal of thoracic disease| PubMed ID: 34992839

2021
Outcomes of lung transplantation from organ donation after medical assistance in dying: First North American experience.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 35108446

2022
2022
Donation after circulatory death donors in high-risk recipients undergoing bilateral lung transplantation: An ISHLT database registry analysis.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 35300913

2022
Importance of tumor size in resectable stage III-N2 non-small cell lung cancer.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 35331553

2022
Performance Measures for Lung Transplantation: Change Is Coming.

The Annals of thoracic surgery| PubMed ID: 35339441

2022
Lung transplantation for acute respiratory distress syndrome.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 35379475

2023
2022
The gift of organ donation as a last wish.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 35430148

2022
2023
2022
Outcomes of lung transplantation at a Canadian center using donors declined in the United States.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 35461711

2022
Donation after circulatory death and lung transplantation.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia| PubMed ID: 35475865

2022
Centralized Organ Recovery and Reconditioning Centers.

Thoracic surgery clinics| PubMed ID: 35512935

2022
Seminars AATS International Roundtable of Lung Transplantation for COVID-19.

Seminars in thoracic and cardiovascular surgery| PubMed ID: 35697136

2022
2022
2022
2022
2022
2022
2022
Extracorporeal life support as a bridge to lung transplantation: Where are we now?

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 36089445

2022
2022
2022
2022
2022
Outcomes of lung transplantation from donors with a history of substance abuse.

The Journal of thoracic and cardiovascular surgery| PubMed ID: 36216597

2023
Evaluation of 10°C as the optimal storage temperature for aspiration-injured donor lungs in a large animal transplant model.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 36216693

2022
Determining the impact of ex-vivo lung perfusion on hospital costs for lung transplantation: A retrospective cohort study.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 36411188

2023
L-alanyl-L-glutamine modified perfusate improves human lung cell functions and extend porcine ex vivo lung perfusion.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 36411189

2023
2023
2023
2023
2022
2023
Triaging donor lungs based on a microaspiration signature that predicts adverse recipient outcome.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 36710092

2023
2023
Alpha-1-antitrypsin safely promotes rapid recovery of pigs after lung transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 37004914

2023
Outcomes after flow cytometry crossmatch-positive lung transplants managed with perioperative desensitization.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons| PubMed ID: 37172694

2023
2023
2023
Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 37315746

2023
Time to extubation for lung transplant recipients represents a pragmatic end-point to guide the development of prognostic tests.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 37406839

2023
2023
2023
2023
2023