Christoph Wittmann

Institute of Biochemical Engineering, Technische Universität Braunschweig

Affiliated withTechnische Universität Braunschweig

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 32	2012

Other Publications

Article	Year
In vivo analysis of intracellular amino acid labelings by GC/MS. Analytical biochemistry\| PubMed ID: 12202258	2002
Derivatization of small biomolecules for optimized matrix-assisted laser desorption/ionization mass spectrometry. Journal of mass spectrometry : JMS\| PubMed ID: 12271439	2002
Correcting mass isotopomer distributions for naturally occurring isotopes. Biotechnology and bioengineering\| PubMed ID: 12325156	2002
Metabolic physiology of aroma-producing Kluyveromyces marxianus. Yeast (Chichester, England)\| PubMed ID: 12402244	2002
Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing corynebacteria. Applied and environmental microbiology\| PubMed ID: 12450803	2002
Integrated optical sensing of dissolved oxygen in microtiter plates: a novel tool for microbial cultivation. Biotechnology and bioengineering\| PubMed ID: 12557316	2003
Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae. Biotechnology and bioengineering\| PubMed ID: 12584756	2003
Characterization and application of an optical sensor for quantification of dissolved O2 in shake-flasks. Biotechnology letters\| PubMed ID: 12882556	2003
Dynamic calibration and dissolved gas analysis using membrane inlet mass spectrometry for the quantification of cell respiration. Rapid communications in mass spectrometry : RCM\| PubMed ID: 14673819	2003
Software tool for automated processing of 13C labeling data from mass spectrometric spectra. BioTechniques\| PubMed ID: 14682055	2003
Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose. Applied and environmental microbiology\| PubMed ID: 14711646	2004
In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome. Journal of bacteriology\| PubMed ID: 14996808	2004
Minibioreactors. Biotechnology letters\| PubMed ID: 15005143	2004
Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria. Analytical biochemistry\| PubMed ID: 15033521	2004
Metabolic network analysis of lysine producing Corynebacterium glutamicum at a miniaturized scale. Biotechnology and bioengineering\| PubMed ID: 15211482	2004
Metabolic network simulation using logical loop algorithm and Jacobian matrix. Metabolic engineering\| PubMed ID: 15491855	2004
Metabolic fluxes in Corynebacterium glutamicum during lysine production with sucrose as carbon source. Applied and environmental microbiology\| PubMed ID: 15574927	2004
Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle-related oscillation in Saccharomyces cerevisiae. Biotechnology and bioengineering\| PubMed ID: 15690349	2005
In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum. Analytical biochemistry\| PubMed ID: 15802143	2005
Theoretical aspects of 13C metabolic flux analysis with sole quantification of carbon dioxide labeling. Computational biology and chemistry\| PubMed ID: 15833440	2005
Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis. Microbial cell factories\| PubMed ID: 16269086	2005
Application of cation-exchange membranes for characterisation and imaging ammonia-oxidising bacteria in soils. FEMS microbiology ecology\| PubMed ID: 16329964	2005
Amplified expression of fructose 1,6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sourc... Applied and environmental microbiology\| PubMed ID: 16332851	2005
Quantification of S-adenosyl methionine in microbial cell extracts. Biotechnology letters\| PubMed ID: 16369687	2006
Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains. Journal of bacteriology\| PubMed ID: 16385051	2006
Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum. Metabolic engineering\| PubMed ID: 16621639	2006
Respirometric 13C flux analysis--Part II: in vivo flux estimation of lysine-producing Corynebacterium glutamicum. Metabolic engineering\| PubMed ID: 16750927	2006
Respirometric 13C flux analysis, Part I: design, construction and validation of a novel multiple reactor system using on-line membrane inlet mass spectrometry. Metabolic engineering\| PubMed ID: 16844397	2006
Comparative study on central metabolic fluxes of Bacillus megaterium strains in continuous culture using 13C labelled substrates. Bioprocess and biosystems engineering\| PubMed ID: 17086410	2007
Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptatio... Applied and environmental microbiology\| PubMed ID: 17122393	2007
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for metabolic flux analyses using isotope-labeled ethanol. Rapid communications in mass spectrometry : RCM\| PubMed ID: 17206598	2007
Physiology of the yeast Kluyveromyces marxianus during batch and chemostat cultures with glucose as the sole carbon source. FEMS yeast research\| PubMed ID: 17233766	2007
Fluxome analysis using GC-MS. Microbial cell factories\| PubMed ID: 17286851	2007
Sampling for metabolome analysis of microorganisms. Analytical chemistry\| PubMed ID: 17411014	2007
Metabolic flux engineering of L-lysine production in Corynebacterium glutamicum--over expression and modification of G6P dehydrogenase. Journal of biotechnology\| PubMed ID: 17624457	2007
Response of the central metabolism of Escherichia coli to modified expression of the gene encoding the glucose-6-phosphate dehydrogenase. FEBS letters\| PubMed ID: 17631881	2007
Response of fluxome and metabolome to temperature-induced recombinant protein synthesis in Escherichia coli. Journal of biotechnology\| PubMed ID: 17689798	2007
Effect of different carbon sources on central metabolic fluxes and the recombinant production of a hydrolase from Thermobifida fusca in Bacillus megaterium. Journal of biotechnology\| PubMed ID: 17826861	2007
Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function. Journal of biotechnology\| PubMed ID: 17919760	2007
Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature biotechnology\| PubMed ID: 17965706	2007
Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum. Microbial cell factories\| PubMed ID: 18339202	2008
The yeast Kluyveromyces marxianus and its biotechnological potential. Applied microbiology and biotechnology\| PubMed ID: 18427804	2008
Analysis of 13C labeling enrichment in microbial culture applying metabolic tracer experiments using gas chromatography-combustion-isotope ratio mass spectrometry. Analytical biochemistry\| PubMed ID: 18565321	2008
Appropriate sampling for intracellular amino acid analysis in five phylogenetically different yeasts. Biotechnology letters\| PubMed ID: 18604477	2008
Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR. Microbiology (Reading, England)\| PubMed ID: 19047758	2008
Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening. Microbial cell factories\| PubMed ID: 19183481	2009
Investigation of the central carbon metabolism of Sorangium cellulosum: metabolic network reconstruction and quantification of pathway fluxes. Journal of microbiology and biotechnology\| PubMed ID: 19190405	2009
OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis. Microbial cell factories\| PubMed ID: 19409084	2009
Metabolic fluxes in the central carbon metabolism of Dinoroseobacter shibae and Phaeobacter gallaeciensis, two members of the marine Roseobacter clade. BMC microbiology\| PubMed ID: 19788729	2009
Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum. Applied and environmental microbiology\| PubMed ID: 19820141	2009
Morphology engineering of Aspergillus niger for improved enzyme production. Biotechnology and bioengineering\| PubMed ID: 19953678	2010
Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties. BMC systems biology\| PubMed ID: 20035624	2009
Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium glutamicum. Advances in biochemical engineering/biotechnology\| PubMed ID: 20140657	2010
Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane. Metabolic engineering\| PubMed ID: 20381632	2010
Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger. Applied microbiology and biotechnology\| PubMed ID: 20502893	2010
Identification and elimination of the competing N-acetyldiaminopentane pathway for improved production of diaminopentane by Corynebacterium glutamicum. Applied and environmental microbiology\| PubMed ID: 20562290	2010
Towards methionine overproduction in Corynebacterium glutamicum--methanethiol and dimethyldisulfide as reduced sulfur sources. Journal of microbiology and biotechnology\| PubMed ID: 20798582	2010
Metabolic fluxes and beyond-systems biology understanding and engineering of microbial metabolism. Applied microbiology and biotechnology\| PubMed ID: 20821203	2010
From zero to hero--design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production. Metabolic engineering\| PubMed ID: 21241816	2011
Metabolic engineering of Corynebacterium glutamicum for production of 1,5-diaminopentane from hemicellulose. Biotechnology journal\| PubMed ID: 21298810	2011
Filamentous fungi in good shape: microparticles for tailor-made fungal morphology and enhanced enzyme production. Bioengineered bugs\| PubMed ID: 21636997	2011
Bio-based production of the platform chemical 1,5-diaminopentane. Applied microbiology and biotechnology\| PubMed ID: 21761208	2011
Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in Corynebacterium glutamicum. Metabolic engineering\| PubMed ID: 21821142	2011
Improved enzyme production by bio-pellets of Aspergillus niger: targeted morphology engineering using titanate microparticles. Biotechnology and bioengineering\| PubMed ID: 21887774	2012
Systems biology of recombinant protein production using Bacillus megaterium. Methods in enzymology\| PubMed ID: 21943898	2011
Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production. Metabolic engineering\| PubMed ID: 22115737	2012
Bio-based production of chemicals, materials and fuels -Corynebacterium glutamicum as versatile cell factory. Current opinion in biotechnology\| PubMed ID: 22138494	2011
Microbial production of the drugs violacein and deoxyviolacein: analytical development and strain comparison. Biotechnology letters\| PubMed ID: 22187076	2012
Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development. Current opinion in biotechnology\| PubMed ID: 22244788	2012
Debottlenecking recombinant protein production in Bacillus megaterium under large scale conditions - targeted precursor feeding designed from metabolomics. Biotechnology and bioengineering\| PubMed ID: 22252649	2012
Industrial biotechnology of Pseudomonas putida and related species. Applied microbiology and biotechnology\| PubMed ID: 22350258	2012