Nabil G. Seidah

Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal

Affiliated withClinical Research Institute of Montreal Institut de recherches cliniques de Montréal

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 97	2012
Publication title Cited by 5	2013

Other Publications

Article	Year
Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity. The Journal of biological chemistry\| PubMed ID: 11756446	2002
Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells. Journal of cell science\| PubMed ID: 11884519	2002
A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus. FEBS letters\| PubMed ID: 11943176	2002
Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy. The American journal of pathology\| PubMed ID: 12057895	2002
The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF). The Biochemical journal\| PubMed ID: 12095415	2002
Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8. DNA sequence : the journal of DNA sequencing and mapping\| PubMed ID: 12180344	2002
Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene. Brain research. Molecular brain research\| PubMed ID: 12191492	2002
Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. Journal of neurochemistry\| PubMed ID: 12358783	2002
Structure-function analysis of the prosegment of the proprotein convertase PC5A. The Journal of biological chemistry\| PubMed ID: 12414802	2003
Role of proprotein convertases in the pathogenic processing of the amyloidosis-associated form of secretory gelsolin. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 12440480	2002
Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein. The Biochemical journal\| PubMed ID: 12444923	2003
Precursor convertases in the secretory pathway, cytosol and extracellular milieu. Essays in biochemistry\| PubMed ID: 12463163	2002
The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1. The Journal of biological chemistry\| PubMed ID: 12529374	2003
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12552133	2003
Proteolytic processing of chromogranin A by the prohormone convertase PC2. Regulatory peptides\| PubMed ID: 12609757	2003
Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo. Histochemistry and cell biology\| PubMed ID: 12649739	2003
The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-i... Cancer research\| PubMed ID: 12670890	2003
Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage. The Biochemical journal\| PubMed ID: 12691605	2003
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nature genetics\| PubMed ID: 12730697	2003
A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. The Journal of biological chemistry\| PubMed ID: 12782636	2003
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. The Journal of clinical investigation\| PubMed ID: 12782675	2003
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. Journal of virology\| PubMed ID: 12885882	2003
Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathway. The Journal of biological chemistry\| PubMed ID: 12970359	2003
Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling. Circulation\| PubMed ID: 14970114	2004
Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein. The Journal of biological chemistry\| PubMed ID: 14970232	2004
Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1. Endocrine\| PubMed ID: 15146101	2004
Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model. The American journal of pathology\| PubMed ID: 15161629	2004
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15178557	2004
Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase. Cardiovascular research\| PubMed ID: 15194465	2004
Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 rece... Biochemical and biophysical research communications\| PubMed ID: 15358140	2004
Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 15358338	2004
NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. The Journal of biological chemistry\| PubMed ID: 15358785	2004
Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation\| PubMed ID: 15466627	2004
The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing. Biochemical and biophysical research communications\| PubMed ID: 15522224	2004
Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus. Biochemical and biophysical research communications\| PubMed ID: 15596135	2005
Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. Journal of neurochemistry\| PubMed ID: 15606899	2005
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. Journal of lipid research\| PubMed ID: 15741654	2005
Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis. Virchows Archiv : an international journal of pathology\| PubMed ID: 15756593	2005
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer research\| PubMed ID: 15899807	2005
Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis. Circulation\| PubMed ID: 15911696	2005
Dual regulation of the LDL receptor--some clarity and new questions. Cell metabolism\| PubMed ID: 16054075	2005
Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. The Journal of biological chemistry\| PubMed ID: 16109723	2005
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virology journal\| PubMed ID: 16115318	2005
富含半胱氨酸的分泌的细菌性 convertases PC5A 和 PACE4 域函数作为细&#x80... Molecular biology of the cell\| PubMed ID: 16135528	2005
Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi. FEBS letters\| PubMed ID: 16213495	2005
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse. Molecular and cellular biology\| PubMed ID: 16354705	2006
Unexpected similarity between the cytosolic West Nile virus NS3 and the secretory furin-like serine proteinases. The Biochemical journal\| PubMed ID: 16371006	2006
The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors. The Journal of biological chemistry\| PubMed ID: 16790437	2006
Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system. Journal of neurochemistry\| PubMed ID: 16893422	2006
Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2. Neuroscience letters\| PubMed ID: 16905251	2006
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications. The Journal of biological chemistry\| PubMed ID: 16912035	2006
The proprotein convertases and their implication in sterol and/or lipid metabolism. Biological chemistry\| PubMed ID: 16913836	2006
Proprotein convertases: lessons from knockouts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17012247	2006
Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. The Journal of biological chemistry\| PubMed ID: 17121831	2007
Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells. European journal of immunology\| PubMed ID: 17171757	2007
The proprotein convertases are potential targets in the treatment of dyslipidemia. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 17351764	2007
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR. Traffic (Copenhagen, Denmark)\| PubMed ID: 17461796	2007
A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female suscept... Developmental biology\| PubMed ID: 17490633	2007
Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms. Medical hypotheses\| PubMed ID: 17502126	2007
The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization. The Journal of biological chemistry\| PubMed ID: 17623657	2007
PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism. The FEBS journal\| PubMed ID: 17645548	2007
Plasma PCSK9 levels correlate with cholesterol in men but not in women. Biochemical and biophysical research communications\| PubMed ID: 17645871	2007
Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells. DNA and cell biology\| PubMed ID: 17867930	2007
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1. Cancer research\| PubMed ID: 17909005	2007
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates. The Journal of biological chemistry\| PubMed ID: 18039650	2008
The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. The Journal of biological chemistry\| PubMed ID: 18039658	2008
Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases. Virology\| PubMed ID: 18061232	2008
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells. The Journal of clinical investigation\| PubMed ID: 18064302	2008
The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains... Journal of molecular neuroscience : MN\| PubMed ID: 18306058	2008
The activation and physiological functions of the proprotein convertases. The international journal of biochemistry & cell biology\| PubMed ID: 18343183	2008
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18378898	2008
PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans. The FEBS journal\| PubMed ID: 18498363	2008
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes & development\| PubMed ID: 18519639	2008
Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein. The Journal of biological chemistry\| PubMed ID: 18559340	2008
Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology (Baltimore, Md.)\| PubMed ID: 18666258	2008
Potential role of proprotein convertase SKI-1 in the mineralization of primary bone. Cells, tissues, organs\| PubMed ID: 18728345	2009
Proprotein convertases as therapeutic targets. Expert opinion on therapeutic targets\| PubMed ID: 18781827	2008
Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. The Journal of biological chemistry\| PubMed ID: 18799458	2008
Emerging viruses: risk of pandemic. Expert review of anti-infective therapy\| PubMed ID: 18847397	2008
PCSK9 as a therapeutic target of dyslipidemia. Expert opinion on therapeutic targets\| PubMed ID: 19063703	2009
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. The Journal of biological chemistry\| PubMed ID: 19074428	2009
Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19179626	2009
PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression. Hepatology (Baltimore, Md.)\| PubMed ID: 19489072	2009
A new method for measurement of total plasma PCSK9: clinical applications. Journal of lipid research\| PubMed ID: 19571328	2010
Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. The Journal of biological chemistry\| PubMed ID: 19635789	2009
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model. Molecular cancer\| PubMed ID: 19737405	2009
PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. FEBS letters\| PubMed ID: 20026049	2010
Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circulation. Cardiovascular genetics\| PubMed ID: 20031622	2009
Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. Journal of lipid research\| PubMed ID: 20048381	2010
Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus. Endocrinology\| PubMed ID: 20130116	2010
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133765	2010
A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. PloS one\| PubMed ID: 20498851	2010
The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis. Current atherosclerosis reports\| PubMed ID: 20623344	2010
Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration. PloS one\| PubMed ID: 20625388	2010
Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 20882679	2010
Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events. The Journal of biological chemistry\| PubMed ID: 20937814	2010
Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. The Journal of biological chemistry\| PubMed ID: 21075843	2011
The proprotein convertase PC7: unique zymogen activation and trafficking pathways. The Journal of biological chemistry\| PubMed ID: 21075846	2011
Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men. Journal of lipid research\| PubMed ID: 21123766	2011
In vivo evidence that furin from hepatocytes inactivates PCSK9. The Journal of biological chemistry\| PubMed ID: 21147780	2011
Surface expression of precursor N-cadherin promotes tumor cell invasion. Neoplasia (New York, N.Y.)\| PubMed ID: 21170270	2010
Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. The Journal of biological chemistry\| PubMed ID: 21209099	2011
Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21273557	2011
Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells. Journal of proteome research\| PubMed ID: 21332221	2011
What lies ahead for the proprotein convertases? Annals of the New York Academy of Sciences\| PubMed ID: 21388412	2011
PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. Journal of lipid research\| PubMed ID: 21518694	2011
N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1. Glycobiology\| PubMed ID: 21527438	2011
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. The Journal of biological chemistry\| PubMed ID: 21550985	2011
Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease. Virology\| PubMed ID: 21612810	2011
Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 21681612	2011
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. The Journal of biological chemistry\| PubMed ID: 21700711	2011
Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome. The British journal of nutrition\| PubMed ID: 21787450	2012
The proprotein convertases, 20 years later. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21805237	2011
Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. Clinical chemistry\| PubMed ID: 21813713	2011
A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. Journal of aging research\| PubMed ID: 21969914	2011
The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography. Atherosclerosis\| PubMed ID: 22051553	2011
Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial. Clinical chemistry\| PubMed ID: 22065156	2012
Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation\| PubMed ID: 22261195	2012
5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation. Chembiochem : a European journal of chemical biology\| PubMed ID: 22262650	2012
SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth. Developmental cell\| PubMed ID: 22340500	2012
Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease. Journal of virology\| PubMed ID: 22357276	2012
Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. The Journal of biological chemistry\| PubMed ID: 22396549	2012
SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication. Antiviral research\| PubMed ID: 22626636	2012
The biology and therapeutic targeting of the proprotein convertases. Nature reviews. Drug discovery\| PubMed ID: 22679642	2012
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia. Atherosclerosis\| PubMed ID: 22683120	2012
Loss of endothelial furin leads to cardiac malformation and early postnatal death. Molecular and cellular biology\| PubMed ID: 22733989	2012
Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PloS one\| PubMed ID: 22848640	2012
Loss- and Gain-of-function PCSK9 Variants: CLEAVAGE SPECIFICITY, DOMINANT NEGATIVE EFFECTS, AND LOW DENSITY LIPOPROTEIN RECEPTOR (LDLR) DEGRADATION. The Journal of biological chemistry\| PubMed ID: 22875854	2012
Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor. Atherosclerosis\| PubMed ID: 23040868	2012
Opposite Roles of Furin and PC5A in N-Cadherin Processing. Neoplasia (New York, N.Y.)\| PubMed ID: 23097623	2012
The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 is needed for the extracellular low density lipoprotein receptor (LDLR) degradation pathway. The Journal of biological chemistry\| PubMed ID: 23105118	2012
Automated design of ligands to polypharmacological profiles. Nature\| PubMed ID: 23235874	2012
Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver. Neoplasia (New York, N.Y.)\| PubMed ID: 23308045	2012
Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum. Clinical biochemistry\| PubMed ID: 23313081	2013
Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in the treatment of hypercholesterolemia and other pathologies. Current pharmaceutical design\| PubMed ID: 23317404	2013
The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins. Traffic (Copenhagen, Denmark)\| PubMed ID: 23350547	2013
Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin. Hepatology (Baltimore, Md.)\| PubMed ID: 23390091	2013
PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. Atherosclerosis\| PubMed ID: 23422832	2013
Correspondence. Hepatology (Baltimore, Md.)\| PubMed ID: 23505014	2013
Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P). Journal of virology\| PubMed ID: 23536681	2013
Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels. PloS one\| PubMed ID: 23544125	2013
Viral envelope glycoprotein processing by proprotein convertases. Antiviral research\| PubMed ID: 23611717	2013
Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency. Atherosclerosis\| PubMed ID: 23623011	2013
Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1). PloS one\| PubMed ID: 23675525	2013
Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype. The Canadian journal of cardiology\| PubMed ID: 23743349	2013
The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. The Journal of biological chemistry\| PubMed ID: 23775089	2013
Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. The Journal of biological chemistry\| PubMed ID: 23918928	2013
PCSK9 prosegment chimera as novel inhibitors of LDLR degradation. PloS one\| PubMed ID: 23951290	2013
Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model. PloS one\| PubMed ID: 24015257	2013
Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24101515	2013
Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes. Immunity\| PubMed ID: 24138882	2013