Xiaodong Sun

Department of Ophthalmology, Shanghai Jiao Tong University School of Medicine

Affiliated withShanghai Jiao Tong University School of Medicine National Clinical Research Center for Eye Diseases Shanghai Clinical Research Center for Eye Diseases

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2023

Other Publications

Article	Year
A potential therapeutic strategy for inhibition of ocular neovascularization with a new endogenous protein: rhEDI-8t. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie\| PubMed ID: 21881847	2011
Late adult onset optic pathway astrocytoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 23790623	2013
Binding pancreaticogastrostomy in laparoscopic central pancreatectomy: a novel technique in laparoscopic pancreatic surgery. Surgical endoscopy\| PubMed ID: 26123326	2016
A2E Suppresses Regulatory Function of RPE Cells in Th1 Cell Differentiation Via Production of IL-1β and Inhibition of PGE2. Investigative ophthalmology & visual science\| PubMed ID: 26641550	2015
Joint Antiangiogenic Effect of ATN-161 and Anti-VEGF Antibody in a Rat Model of Early Wet Age-Related Macular Degeneration. Molecular pharmaceutics\| PubMed ID: 27089240	2016
CHOROIDAL THICKNESS IN UNILATERAL IDIOPATHIC MACULAR HOLE: A Cross-Sectional Study and Meta-Analysis. Retina (Philadelphia, Pa.)\| PubMed ID: 27322947	2017
Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review. Drug design, development and therapy\| PubMed ID: 27330279	2016
Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 27992238	2017
Involvement of XBP1s in Blue Light-Induced A2E-Containing Retinal Pigment Epithelium Cell Death. Ophthalmic research\| PubMed ID: 28099966	2017
MicroRNA Expression Patterns Involved in Amyloid Beta-Induced Retinal Degeneration. Investigative ophthalmology & visual science\| PubMed ID: 28324113	2017
Paravascular abnormalities observed by spectral domain optical coherence tomography are risk factors for retinoschisis in eyes with high myopia. Acta ophthalmologica\| PubMed ID: 29171725	2018
Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults. Journal of ophthalmology\| PubMed ID: 29318037	2017
Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs. Biochemical and biophysical research communications\| PubMed ID: 29402409	2018
Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescence. Cell death & disease\| PubMed ID: 29415988	2018
Development of a new valid and reliable microsurgical skill assessment scale for ophthalmology residents. BMC ophthalmology\| PubMed ID: 29506509	2018
Choroidal and Retinal Thickness of Highly Myopic Eyes with Early Stage of Myopic Chorioretinopathy: Tessellation. Journal of ophthalmology\| PubMed ID: 29607214	2018
Choroidal pericytes promote subretinal fibrosis after experimental photocoagulation. Disease models & mechanisms\| PubMed ID: 29622551	2018
Inhibition of Mitochondrial Fission Preserves Photoreceptors after Retinal Detachment. The American journal of pathology\| PubMed ID: 29684364	2018
Conbercept for Treatment of Neovascular Age-related Macular Degeneration: Results of the Randomized Phase 3 PHOENIX Study. American journal of ophthalmology\| PubMed ID: 30148987	2019
DNMT1 and Sp1 competitively regulate the expression of BACE1 in A2E-mediated photo-oxidative damage in RPE cells. Neurochemistry international\| PubMed ID: 30273642	2018
Identification of novel PROM1 mutations responsible for autosomal recessive maculopathy with rod-cone dystrophy. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie\| PubMed ID: 30588538	2019
Modulation of α-adrenoceptor signalling protects photoreceptors after retinal detachment by inhibiting oxidative stress and inflammation. British journal of pharmacology\| PubMed ID: 30588605	2019
UMSC-derived exosomes promote retinal ganglion cells survival in a rat model of optic nerve crush. Journal of chemical neuroanatomy\| PubMed ID: 30639447	2019
Appearance of Polypoidal Lesions in Patients With Polypoidal Choroidal Vasculopathy Using Swept-Source Optical Coherence Tomographic Angiography. JAMA ophthalmology\| PubMed ID: 30998817	2019
Progression and new onset of macular retinoschisis in myopic choroidal neovascularization eyes after Conbercept therapy: a post-hoc analysis. Eye (London, England)\| PubMed ID: 31358922	2020
Complement system and age-related macular degeneration: drugs and challenges. Drug design, development and therapy\| PubMed ID: 31409975	2019
Intraocular VEGF deprivation induces degeneration and fibrogenic response in retina. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31648566	2019
Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration. Investigative ophthalmology & visual science\| PubMed ID: 31675076	2019
Autophagy activated via GRP78 to alleviate endoplasmic reticulum stress for cell survival in blue light-mediated damage of A2E-laden RPEs. BMC ophthalmology\| PubMed ID: 31823795	2019
Quantitative assessment of the retinal microvasculature and choriocapillaris in myopic patients using swept-source optical coherence tomography angiography. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie\| PubMed ID: 32144487	2020
Intravitreal Aflibercept versus Laser Photocoagulation in Asian Patients with Diabetic Macular Edema: The VIVID-East Study. Clinical ophthalmology (Auckland, N.Z.)\| PubMed ID: 32210527	2020
Evaluation of the association of macular ganglion cell-inner plexiform layer thickness and myopia in Chinese young adults. Eye (London, England)\| PubMed ID: 32291406	2021
3-Methyladenine Alleviates Experimental Subretinal Fibrosis by Inhibiting Macrophages and M2 Polarization Through the PI3K/Akt Pathway. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 32552228	2020
xCT regulates redox homeostasis and promotes photoreceptor survival after retinal detachment. Free radical biology & medicine\| PubMed ID: 32679366	2020
Photoreceptors Degenerate Through Pyroptosis After Experimental Retinal Detachment. Investigative ophthalmology & visual science\| PubMed ID: 32697303	2020
The Efficacy of Conbercept in Polypoidal Choroidal Vasculopathy: A Systematic Review. Journal of ophthalmology\| PubMed ID: 32855818	2020
ROS production and mitochondrial dysfunction driven by PU.1-regulated NOX4-p22 activation in Aβ-induced retinal pigment epithelial cell injury. Theranostics\| PubMed ID: 33052238	2020
Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice. Nature biomedical engineering\| PubMed ID: 33398131	2021
SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production. Frontiers in cell and developmental biology\| PubMed ID: 33681224	2021
Replacement of polyps with type 1 macular neovascularization in polypoidal choroidal vasculopathy imaged with swept source OCT angiography. American journal of ophthalmology case reports\| PubMed ID: 33796797	2021
Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography? Eye (London, England)\| PubMed ID: 33833415	2022
Peripapillary Vessel Density in Eyes with Rhegmatogenous Retinal Detachment after Pars Plana Vitrectomy. Journal of ophthalmology\| PubMed ID: 33859835	2021
The Interaction Between Microglia and Macroglia in Glaucoma. Frontiers in neuroscience\| PubMed ID: 34121982	2021
Modeling Cone/Cone-Rod Dystrophy Pathology by AAV-Mediated Overexpression of Mutant CRX Protein in the Mouse Retina. Translational vision science & technology\| PubMed ID: 34144598	2021
Geographic variations in idiopathic epiretinal membranes in China. Annals of translational medicine\| PubMed ID: 34350253	2021
Safety of Receiving Anti-Vascular Endothelial Growth Factor Intravitreal Injection in Office-Based vs Operating Room Settings: A Meta-analysis. JAMA ophthalmology\| PubMed ID: 34410325	2021
Improvement of human embryonic stem cell-derived retinal pigment epithelium cell adhesion, maturation, and function through coating with truncated recombinant human vitronectin. International journal of ophthalmology\| PubMed ID: 34414078	2021
Retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGA1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 34418172	2021
Myosin 1f-mediated activation of microglia contributes to the photoreceptor degeneration in a mouse model of retinal detachment. Cell death & disease\| PubMed ID: 34628463	2021
CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration. National science review\| PubMed ID: 34692105	2020
Identification of a novel RPGR mutation associated with X-linked cone-rod dystrophy in a Chinese family. BMC ophthalmology\| PubMed ID: 34800980	2021
Synthetic anti-angiogenic genomic therapeutics for treatment of neovascular age-related macular degeneration. Asian journal of pharmaceutical sciences\| PubMed ID: 34849167	2021
Choroidal Changes in Eyes With Polypoidal Choroidal Vasculopathy After Anti-VEGF Therapy Imaged With Swept-Source OCT Angiography. Investigative ophthalmology & visual science\| PubMed ID: 34860239	2021
DIA Comparative Proteomic Analysis of Retro-oil Fluid and Vitreous Fluid From Retinal Detachment Patients. Frontiers in molecular biosciences\| PubMed ID: 34926578	2021
Associations of sensory impairment and cognitive function in middle-aged and older Chinese population: The China Health and Retirement Longitudinal Study. Journal of global health\| PubMed ID: 34956639	2021
The Association of Sleep Duration With Vision Impairment in Middle-Aged and Elderly Adults: Evidence From the China Health and Retirement Longitudinal Study. Frontiers in medicine\| PubMed ID: 35004745	2021
Malondialdehyde-Modified Photoreceptor Outer Segments Promote Choroidal Neovascularization in Mice. Translational vision science & technology\| PubMed ID: 35015060	2022
HMGB2 causes photoreceptor death via down-regulating Nrf2/HO-1 and up-regulating NF-κB/NLRP3 signaling pathways in light-induced retinal degeneration model. Free radical biology & medicine\| PubMed ID: 35091064	2022
Publication Trends of Research on Polypoidal Choroidal Vasculopathy During 2001-2020: A 20-Year Bibliometric Study. Frontiers in medicine\| PubMed ID: 35174182	2021
A novel and efficient murine model of Bietti crystalline dystrophy. Disease models & mechanisms\| PubMed ID: 35230417	2022
Cysteine Substitution and Calcium-Binding Mutations in cbEGF-Like Domains Are Associated With Severe Ocular Involvement in Patients With Congenital Ectopia Lentis. Frontiers in cell and developmental biology\| PubMed ID: 35237611	2021
Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure. Nature communications\| PubMed ID: 35351879	2022
Glaucoma Characterization by Machine Learning of Tear Metabolic Fingerprinting. Small methods\| PubMed ID: 35388987	2022
Contribution of Interleukin-17A to Retinal Degenerative Diseases. Frontiers in immunology\| PubMed ID: 35392087	2022
Visual impairment and depression in China: a 7-year follow-up study from national longitudinal surveys. BMJ open\| PubMed ID: 35477885	2022
Prediction of the short-term efficacy of anti-VEGF therapy for neovascular age-related macular degeneration using optical coherence tomography angiography. Eye and vision (London, England)\| PubMed ID: 35505390	2022
Development and Validation of a Novel Metabolic Signature-Based Prognostic Model for Uveal Melanoma. Translational vision science & technology\| PubMed ID: 35536719	2022
Targeting C3b/C4b and VEGF with a bispecific fusion protein optimized for neovascular age-related macular degeneration therapy. Science translational medicine\| PubMed ID: 35648811	2022
Biscuit consumption and diabetic retinopathy incidence in adults in the United States. Diabetology & metabolic syndrome\| PubMed ID: 35794635	2022
Application of an innovative grid-based surveillance strategy to ensure elimination and prevent reintroduction of malaria in high-risk border communities in China. BMC public health\| PubMed ID: 35836156	2022
High glucose promotes IL-17A-induced gene expression through histone acetylation in retinal pigment epithelium cells. International immunopharmacology\| PubMed ID: 35978498	2022
Prevalence and Risk Factors of Glaucoma Among Chinese People From the China Health and Retirement Longitudinal Study. Journal of glaucoma\| PubMed ID: 35980856	2022
Construction of a ferroptosis-associated circRNA-miRNA-mRNA network in age-related macular degeneration. Experimental eye research\| PubMed ID: 36044964	2022
A tunable genome editing system of the prime editor mediated by dihydrofolate reductase. Journal of genetics and genomics = Yi chuan xue bao\| PubMed ID: 36055523	2023
Progression of Polypoidal Lesions Associated with Exudative Recurrence in Polypoidal Choroidal Vasculopathy. Ophthalmology\| PubMed ID: 36152843	2023
Fat mass and obesity-associated protein alleviates Aβ induced retinal pigment epithelial cells degeneration via PKA/CREB signaling pathway. Cell biology international\| PubMed ID: 36378581	2023
Aquaporin 11 alleviates retinal Müller intracellular edema through water efflux in diabetic retinopathy. Pharmacological research\| PubMed ID: 36403720	2023
A Novel Bispecific Fusion Protein Targeting C3b/C4b and VEGF in Patients With nAMD: A Randomized, Open-Label, Phase 1b Study. American journal of ophthalmology\| PubMed ID: 36410472	2023
Growth of nonexudative macular neovascularization in age-related macular degeneration: an indicator of biological lesion activity. Eye (London, England)\| PubMed ID: 36434285	2023
Cognitive Impairment in Phenotypic Leber Hereditary Optic Neuropathy Caused by Mutation in Nuclear Gene NDUFAF5. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society\| PubMed ID: 36580434	2022
PFKFB3 knockdown attenuates Amyloid β-Induced microglial activation and retinal pigment epithelium disorders in mice. International immunopharmacology\| PubMed ID: 36638665	2023
Residential greenness exposure and decreased prevalence of diabetic retinopathy: A nationwide analysis in China. Environmental research\| PubMed ID: 36642124	2023
CircRNA Uxs1/miR-335-5p/PGF axis regulates choroidal neovascularization via the mTOR/p70 S6k pathway. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 36690073	2023
OUTER RETINAL TUBULATION IN BIETTI CRYSTALLINE DYSTROPHY ASSOCIATED WITH THE RETINAL PIGMENT EPITHELIUM ATROPHY. Retina (Philadelphia, Pa.)\| PubMed ID: 36729610	2023
The cause of redetachment after vitrectomy with air tamponade for a cohort of 1715 patients with retinal detachment: an analysis of retinal breaks reopening. Eye and vision (London, England)\| PubMed ID: 36732872	2023
Predictive value of pigment epithelial detachment markers for visual acuity outcomes in neovascular age-related macular degeneration. BMC ophthalmology\| PubMed ID: 36869310	2023
The association between obesity and glaucoma in older adults: evidence from the China Health and Retirement Longitudinal Study. Epidemiology and health\| PubMed ID: 36915268	2023
Bifidobacterium promotes retinal ganglion cell survival by regulating the balance of retinal glial cells. CNS neuroscience & therapeutics\| PubMed ID: 36924268	2023
METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition. Journal of molecular cell biology\| PubMed ID: 36945110	2023
Repurposing picropodophyllin as a potential thyroid eye disease treatment via delaying mitotic clonal expansion through a patient-derived preclinical platform. Clinical and translational medicine\| PubMed ID: 37012693	2023
Association between previous cataract surgery and cognition among middle-aged and older Chinese: the China health and retirement longitudinal study (CHARLS). BMC ophthalmology\| PubMed ID: 37259095	2023
Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022). Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih\| PubMed ID: 37263796	2023
Diabetic retinopathy in China: Epidemiology, screening and treatment trends-A review. Clinical & experimental ophthalmology\| PubMed ID: 37381613	2023
Associations between blood pressure levels and diabetic retinopathy in patients with diabetes mellitus: A population-based study. Heliyon\| PubMed ID: 37484372	2023
High Myopia Normative Database of Peripapillary Retinal Nerve Fiber Layer Thickness to Detect Myopic Glaucoma in a Chinese Population. Ophthalmology\| PubMed ID: 37499953	2023
Rapid and Sensitive Diagnosis of Leber Hereditary Optic Neuropathy Variants Using CRISPR/Cas12a Detection. The Journal of molecular diagnostics : JMD\| PubMed ID: 37517824	2023
The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study. Epidemiology and health\| PubMed ID: 37536720	2023
Macrophage promotes pathological neovascularization in age-related macular degeneration. Life science alliance\| PubMed ID: 37550000	2023
Prevalence and optical coherence tomography analyses of outer retinal tubulations in Chinese population with inherited retinal diseases. Eye (London, England)\| PubMed ID: 37553355	2023
AAV-mediated base-editing therapy ameliorates the disease phenotypes in a mouse model of retinitis pigmentosa. Nature communications\| PubMed ID: 37582961	2023
Nomogram of uveal melanoma as prediction model of metastasis risk. Heliyon\| PubMed ID: 37609406	2023
Genetic Factors and Characteristics on Spectral-Domain Optical Coherence Tomography Are Associated to Choroidal Thickness in ABCA4-Related Retinopathy Factors of Choroidal Thickness in ABCA4... Retina (Philadelphia, Pa.)\| PubMed ID: 37695977	2023
Dynamic changes in macrophage morphology during the progression of choroidal neovascularization in a laser-induced choroidal neovascularization mouse model. BMC ophthalmology\| PubMed ID: 37803306	2023
Conducting gene therapy clinical trials based on natural history studies for inherited retinal diseases in Chinese population. Advances in ophthalmology practice and research\| PubMed ID: 37846429	2023
Visual impairment and blindness caused by retinal diseases: A nationwide register-based study. Journal of global health\| PubMed ID: 37921040	2023