Ewan C. Goligher

Toronto General Hospital Research Institute

Affiliated withToronto General Hospital Research Institute University of Toronto University Health Network

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2023

Other Publications

Article	Year
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Tri... JAMA\| PubMed ID: 30347031	2018
Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure. The Lancet. Respiratory medicine\| PubMed ID: 30455078	2019
Diaphragm-protective mechanical ventilation. Current opinion in critical care\| PubMed ID: 30531536	2019
Myotrauma in mechanically ventilated patients. Intensive care medicine\| PubMed ID: 30741329	2019
Withholding or withdrawing life support versus physician-assisted death: a distinction with a difference? Current opinion in anaesthesiology\| PubMed ID: 30817393	2019
Lung- and Diaphragm-protective Ventilation in Acute Respiratory Distress Syndrome: Rationale and Challenges. Anesthesiology\| PubMed ID: 30844950	2019
Optimal Ventilator Strategies in Acute Respiratory Distress Syndrome. Seminars in respiratory and critical care medicine\| PubMed ID: 31060090	2019
Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design. Intensive care medicine\| PubMed ID: 31432216	2019
Respiratory Drive in Critically Ill Patients. Pathophysiology and Clinical Implications. American journal of respiratory and critical care medicine\| PubMed ID: 31437406	2020
A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation. Critical care (London, England)\| PubMed ID: 31694692	2019
Editorial: Lung and diaphragm-protective ventilation: setting new concepts in historical context. Current opinion in critical care\| PubMed ID: 31789946	2020
Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults. JAMA network open\| PubMed ID: 32074293	2020
Airway Occlusion Pressure As an Estimate of Respiratory Drive and Inspiratory Effort during Assisted Ventilation. American journal of respiratory and critical care medicine\| PubMed ID: 32097569	2020
Monitoring Patient Respiratory Effort During Mechanical Ventilation: Lung and Diaphragm-Protective Ventilation. Critical care (London, England)\| PubMed ID: 32204729	2020
Lung- and Diaphragm-Protective Ventilation. American journal of respiratory and critical care medicine\| PubMed ID: 32516052	2020
Monitoring patient-ventilator interaction by an end-expiratory occlusion maneuver. Intensive care medicine\| PubMed ID: 32623476	2020
Association of Mortality with Neuromuscular Blockade Differs according to Baseline Diaphragm Thickness. American journal of respiratory and critical care medicine\| PubMed ID: 32717150	2020
Anti-Thrombotic Therapy to Ameliorate Complications of COVID-19 (ATTACC): Study design and methodology for an international, adaptive Bayesian randomized controlled trial. Clinical trials (London, England)\| PubMed ID: 32815416	2020
Anticipating and managing coagulopathy and thrombotic manifestations of severe COVID-19. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 32816822	2020
Comparing the Effects of Tidal Volume, Driving Pressure, and Mechanical Power on Mortality in Trials of Lung-Protective Mechanical Ventilation. Respiratory care\| PubMed ID: 32843513	2021
Effect of Driving Pressure Change During Extracorporeal Membrane Oxygenation in Adults With Acute Respiratory Distress Syndrome: A Randomized Crossover Physiologic Study. Critical care medicine\| PubMed ID: 33044283	2020
Validity of Empirical Estimates of the Ratio of Dead Space to Tidal Volume in ARDS. Respiratory care\| PubMed ID: 33082218	2021
Response to Ventilator Adjustments for Predicting Acute Respiratory Distress Syndrome Mortality. Driving Pressure versus Oxygenation. Annals of the American Thoracic Society\| PubMed ID: 33112644	2021
Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort. Intensive care medicine\| PubMed ID: 33140181	2020
Clinical trials in critical care: can a Bayesian approach enhance clinical and scientific decision making? The Lancet. Respiratory medicine\| PubMed ID: 33227237	2021
Is severe COVID-19 pneumonia a typical or atypical form of ARDS? And does it matter? Intensive care medicine\| PubMed ID: 33237346	2021
Searching for the Optimal PEEP in Patients Without ARDS: High, Low, or in Between? JAMA\| PubMed ID: 33295963	2020
A manifesto for the future of ICU trials. Critical care (London, England)\| PubMed ID: 33298134	2020
Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients. Critical care (London, England)\| PubMed ID: 33430930	2021
Association of Thoracic Computed Tomographic Measurements and Outcomes in Patients with Hematologic Malignancies Requiring Mechanical Ventilation. Annals of the American Thoracic Society\| PubMed ID: 33433272	2021
Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance. American journal of respiratory and critical care medicine\| PubMed ID: 33439781	2021
Diaphragm echodensity in mechanically ventilated patients: a description of technique and outcomes. Critical care (London, England)\| PubMed ID: 33593412	2021
Postextubation Respiratory Support: Of Clinical Trials and Clinical Decisions. American journal of respiratory and critical care medicine\| PubMed ID: 33901412	2021
Abdominal Muscle Use During Spontaneous Breathing and Cough in Patients Who Are Mechanically Ventilated: A Bi-center Ultrasound Study. Chest\| PubMed ID: 34090872	2021
How cutting-edge trial design can assess outcomes. Current opinion in critical care\| PubMed ID: 34334624	2021
Association of different positive end-expiratory pressure selection strategies with all-cause mortality in adult patients with acute respiratory distress syndrome. Systematic reviews\| PubMed ID: 34384488	2021
What Can We Learn From Monitoring Diaphragm Activity in Infants? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies\| PubMed ID: 34734896	2021
Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis. Intensive care medicine\| PubMed ID: 34825256	2022
Impact of Reverse Triggering Dyssynchrony during Lung-Protective Ventilation on Diaphragm Function: An Experimental Model. American journal of respiratory and critical care medicine\| PubMed ID: 34941477	2022
Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis... American journal of respiratory and critical care medicine\| PubMed ID: 35180042	2022
Phrenic Nerve Block and Respiratory Effort in Pigs and Critically Ill Patients with Acute Lung Injury. Anesthesiology\| PubMed ID: 35348581	2022
EXpert consensus On Diaphragm UltraSonography in the critically ill (EXODUS): a Delphi consensus statement on the measurement of diaphragm ultrasound-derived parameters in a critical care se... Critical care (London, England)\| PubMed ID: 35395861	2022
Physiology Is Vital to Precision Medicine in Acute Respiratory Distress Syndrome and Sepsis. American journal of respiratory and critical care medicine\| PubMed ID: 35442864	2022
Validation of a Web-based Platform for Online Training in Point-of-Care Diaphragm Ultrasound. ATS scholar\| PubMed ID: 35633997	2022
Phrenic nerve stimulation to protect the diaphragm, lung, and brain during mechanical ventilation. Intensive care medicine\| PubMed ID: 35688993	2022
Noninvasive and invasive mechanical ventilation for neurologic disorders. Handbook of clinical neurology\| PubMed ID: 36031314	2022
Strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure: a physiological trial. Critical care (London, England)\| PubMed ID: 36038890	2022
A Window Into the Future: The Diagnostic and Prognostic Utility of Respiratory Muscle Ultrasound in Optimizing Mechanical Ventilation. Respiratory care\| PubMed ID: 36266056	2022
The religious character of secular arguments supporting euthanasia and what it implies for conscientious practice in medicine. Theoretical medicine and bioethics\| PubMed ID: 36449202	2023
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study. The Lancet. Respiratory medicine\| PubMed ID: 36693401	2023
Linking Acute Physiology to Outcomes in the ICU: Challenges and Solutions for Research. American journal of respiratory and critical care medicine\| PubMed ID: 36705985	2023
Monitoring Respiratory Effort and Lung-distending Pressure Noninvasively during Mechanical Ventilation: Ready for Prime Time. Anesthesiology\| PubMed ID: 36749421	2023
Diaphragm Neurostimulation Assisted Ventilation in Critically Ill Patients. American journal of respiratory and critical care medicine\| PubMed ID: 36917765	2023
Association of Days Alive and at Home at Day 90 After Intensive Care Unit Admission With Long-term Survival and Functional Status Among Mechanically Ventilated Patients. JAMA network open\| PubMed ID: 36929399	2023
Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19. JAMA\| PubMed ID: 36942550	2023
Lung Recruitment Assessed by Electrical Impedance Tomography (RECRUIT): A Multicenter Study of COVID-19 Acute Respiratory Distress Syndrome. American journal of respiratory and critical care medicine\| PubMed ID: 37097986	2023
Reply to Fernández. American journal of respiratory and critical care medicine\| PubMed ID: 37159944	2023
Driving pressure: applying the concept at the bedside. Intensive care medicine\| PubMed ID: 37191695	2023
Bringing Clinical Trials to the Bedside: Conditional Average Treatment Effects in the Balanced Solution versus Saline in Intensive Care Study (BaSICS) Trial. Annals of the American Thoracic Society\| PubMed ID: 37261790	2023
Heterogeneous Treatment Effects of Extracorporeal CO Removal in Acute Hypoxemic Respiratory Failure. American journal of respiratory and critical care medicine\| PubMed ID: 37433221	2023
Driving pressure: pitfalls of methods that do not use esophageal pressure measurement. Author's reply. Intensive care medicine\| PubMed ID: 37466671	2023
Proof of Concept for Continuous On-Demand Phrenic Nerve Stimulation to Prevent Diaphragm Disuse during Mechanical Ventilation (STIMULUS): A Phase 1 Clinical Trial. American journal of respiratory and critical care medicine\| PubMed ID: 37642635	2023
Phrenic Nerve Stimulation for Acute Respiratory Failure. Respiratory care\| PubMed ID: 37875317	2023
Simvastatin in Critically Ill Patients with Covid-19. The New England journal of medicine\| PubMed ID: 37888913	2023
Lung and Diaphragm Protection During Mechanical Ventilation: Synchrony Matters. Critical care medicine\| PubMed ID: 37902352	2023