Stephen Kadlecek

Department of Radiology, University of Pennsylvania

Affiliated withUniversity of Pennsylvania

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2023

Other Publications

Article	Year
Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results. Academic radiology\| PubMed ID: 16253848	2005
Measurements of regional alveolar oxygen pressure using hyperpolarized 3He MRI. Academic radiology\| PubMed ID: 16253855	2005
Multiple regression method for pulmonary apparent diffusion coefficient measurement by hyperpolarized 3He MRI. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 17457799	2007
Optimization of scan parameters in pulmonary partial pressure oxygen measurement by hyperpolarized 3He MRI. Magnetic resonance in medicine\| PubMed ID: 18050348	2008
Early changes of lung function and structure in an elastase model of emphysema--a hyperpolarized 3He MRI study. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 18063806	2008
Measurement of pulmonary partial pressure of oxygen and oxygen depletion rate with hyperpolarized helium-3 MRI: a preliminary reproducibility study on pig model. Academic radiology\| PubMed ID: 18486007	2008
A robust method for estimating regional pulmonary parameters in presence of noise. Academic radiology\| PubMed ID: 18486010	2008
Simultaneous measurement of pulmonary partial pressure of oxygen and apparent diffusion coefficient by hyperpolarized 3He MRI. Magnetic resonance in medicine\| PubMed ID: 19230017	2009
Quantitative assessment of lung using hyperpolarized magnetic resonance imaging. Proceedings of the American Thoracic Society\| PubMed ID: 19687215	2009
Improved technique for measurement of regional fractional ventilation by hyperpolarized 3He MRI. Magnetic resonance in medicine\| PubMed ID: 19877277	2010
Optimal transfer of spin-order between a singlet nuclear pair and a heteronucleus. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 20427216	2010
Regional correlation of emphysematous changes in lung function and structure: a comparison between pulmonary function testing and hyperpolarized MRI metrics. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 20884833	2011
Quantitative assessment of lung ventilation and microstructure in an animal model of idiopathic pulmonary fibrosis using hyperpolarized gas MRI. Academic radiology\| PubMed ID: 20934126	2010
Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 21127207	2011
Regional determination of oxygen uptake in rodent lungs using hyperpolarized gas and an analytical treatment of intrapulmonary gas redistribution. NMR in biomedicine\| PubMed ID: 21387449	2011
A simple and low-cost device for generating hyperpolarized contrast agents using parahydrogen. NMR in biomedicine\| PubMed ID: 21845739	2011
Regional function-structure relationships in lungs of an elastase murine model of emphysema. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 21940853	2012
A multislice single breath-hold scheme for imaging alveolar oxygen tension in humans. Magnetic resonance in medicine\| PubMed ID: 22190347	2012
Multislice fractional ventilation imaging in large animals with hyperpolarized gas MRI. NMR in biomedicine\| PubMed ID: 22290603	2012
Determination of the singlet state lifetime of dissolved nitrous oxide from high field relaxation measurements. The Journal of chemical physics\| PubMed ID: 22583250	2012
Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs. Critical care medicine\| PubMed ID: 23263577	2013
A variability study of regional alveolar oxygen tension measurement in humans using hyperpolarized (3) He MRI. Magnetic resonance in medicine\| PubMed ID: 23382040	2013
Accelerated fractional ventilation imaging with hyperpolarized Gas MRI. Magnetic resonance in medicine\| PubMed ID: 23400938	2013
Positive end-expiratory pressure increments during anesthesia in normal lung result in hysteresis and greater numbers of smaller aerated airspaces. Anesthesiology\| PubMed ID: 24025616	2013
Regional alveolar partial pressure of oxygen measurement with parallel accelerated hyperpolarized gas MRI. Academic radiology\| PubMed ID: 24029054	2013
Metabolic spectroscopy of inflammation in a bleomycin-induced lung injury model using hyperpolarized 1-(13) C pyruvate. NMR in biomedicine\| PubMed ID: 24865640	2014
Hyperpolarized gas diffusion MRI for the study of atelectasis and acute respiratory distress syndrome. NMR in biomedicine\| PubMed ID: 24920074	2014
Alterations of regional alveolar oxygen tension in asymptomatic current smokers: assessment with hyperpolarized (3)He MR imaging. Radiology\| PubMed ID: 25322340	2015
The effect of exogenous substrate concentrations on true and apparent metabolism of hyperpolarized pyruvate in the isolated perfused lung. NMR in biomedicine\| PubMed ID: 25330438	2014
Efficient production of hyperpolarized bicarbonate by chemical reaction on a DNP precursor to measure pH. Magnetic resonance in medicine\| PubMed ID: 25393101	2015
Vertical gradients in regional alveolar oxygen tension in supine human lung imaged by hyperpolarized 3He MRI. NMR in biomedicine\| PubMed ID: 25395184	2014
Semiautomatic segmentation of longitudinal computed tomography images in a rat model of lung injury by surfactant depletion. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 25640150	2015
Versatile pulse sequence device to conserve hyperpolarization for NMR and MRI studies. Magnetic resonance in medicine\| PubMed ID: 25976973	2016
Oxygen-weighted Hyperpolarized (3)He MR Imaging: A Short-term Reproducibility Study in Human Subjects. Radiology\| PubMed ID: 26110668	2015
Ascorbic acid prolongs the viability and stability of isolated perfused lungs: A mechanistic study using 31P and hyperpolarized 13C nuclear magnetic resonance. Free radical biology & medicine\| PubMed ID: 26165188	2015
Low-temperature dynamic nuclear polarization of gases in Frozen mixtures. Magnetic resonance in medicine\| PubMed ID: 26444315	2016
Multibreath alveolar oxygen tension imaging. Magnetic resonance in medicine\| PubMed ID: 26467179	2016
Visualizing the Propagation of Acute Lung Injury. Anesthesiology\| PubMed ID: 26536308	2016
Mild loss of lung aeration augments stretch in healthy lung regions. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 26662053	2016
Regional Fractional Ventilation by Using Multibreath Wash-in (3)He MR Imaging. Radiology\| PubMed ID: 26785042	2016
The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging. Advanced drug delivery reviews\| PubMed ID: 27599979	2017
In vivo pH mapping of injured lungs using hyperpolarized [1- C]pyruvate. Magnetic resonance in medicine\| PubMed ID: 27714832	2017
A hybrid multibreath wash-in wash-out lung function quantification scheme in human subjects using hyperpolarized He MRI for simultaneous assessment of specific ventilation, alveolar oxygen ... Magnetic resonance in medicine\| PubMed ID: 27734519	2017
In vivo imaging of the progression of acute lung injury using hyperpolarized [1- C] pyruvate. Magnetic resonance in medicine\| PubMed ID: 28074497	2017
Hyperpolarized gas diffusion MRI of biphasic lung inflation in short- and long-term emphysema models. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 28473321	2017
Tidal changes on CT and progression of ARDS. Thorax\| PubMed ID: 28634220	2017
Quantifying reaction kinetics of the non-enzymatic decarboxylation of pyruvate and production of peroxymonocarbonate with hyperpolarized C-NMR. Physical chemistry chemical physics : PCCP\| PubMed ID: 28703828	2017
Unstable Inflation Causing Injury. Insight from Prone Position and Paired Computed Tomography Scans. American journal of respiratory and critical care medicine\| PubMed ID: 29420904	2018
Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach. Scientific reports\| PubMed ID: 29476083	2018
Rapid assessment of pulmonary gas transport with hyperpolarized 129Xe MRI using a 3D radial double golden-means acquisition with variable flip angles. Magnetic resonance in medicine\| PubMed ID: 29682792	2018
Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging. Scientific reports\| PubMed ID: 29743565	2018
A Model for Predicting Future FEV1 Decline in Smokers Using Hyperpolarized He Magnetic Resonance Imaging. Academic radiology\| PubMed ID: 30087068	2019
Assessment of flip angle-TR equivalence for standardized dissolved-phase imaging of the lung with hyperpolarized 129Xe MRI. Magnetic resonance in medicine\| PubMed ID: 30346083	2019
Multibreath Hyperpolarized He Imaging Scheme to Measure Alveolar Oxygen Tension and Apparent Diffusion Coefficient. Academic radiology\| PubMed ID: 30630659	2019
Measurement of Regional 2D Gas Transport Efficiency in Rabbit Lung Using Hyperpolarized 129Xe MRI. Scientific reports\| PubMed ID: 30787357	2019
Quantification of Ventilation and Gas Uptake in Free-Breathing Mice With Hyperpolarized Xe MRI. IEEE transactions on medical imaging\| PubMed ID: 30990426	2019
Detection of lung transplant rejection in a rat model using hyperpolarized [1- C] pyruvate-based metabolic imaging. NMR in biomedicine\| PubMed ID: 31112351	2019
Hyperpolarized Metabolic Imaging Detects Latent Hepatocellular Carcinoma Domains Surviving Locoregional Therapy. Hepatology (Baltimore, Md.)\| PubMed ID: 31553806	2020
Computational pipeline for estimation of small-molecule T1 relaxation times. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 32339979	2020
Investigating biases in the measurement of apparent alveolar septal wall thickness with hyperpolarized 129Xe MRI. Magnetic resonance in medicine\| PubMed ID: 32557808	2020
Pulmonary pyruvate metabolism as an index of inflammation and injury in a rat model of acute respiratory distress syndrome. NMR in biomedicine\| PubMed ID: 32681670	2020
Positional Therapy and Regional Pulmonary Ventilation. Anesthesiology\| PubMed ID: 32773690	2020
Metabolic Imaging and Biological Assessment: Platforms to Evaluate Acute Lung Injury and Inflammation. Frontiers in physiology\| PubMed ID: 32982768	2020
Measuring pulmonary gas exchange using compartment-selective xenon-polarization transfer contrast (XTC) MRI. Magnetic resonance in medicine\| PubMed ID: 33283943	2021
Diminishing Efficacy of Prone Positioning With Late Application in Evolving Lung Injury. Critical care medicine\| PubMed ID: 33938714	2021
Ventilation heterogeneity imaged by multibreath wash-ins of hyperpolarized He and Xe in healthy rabbits. The Journal of physiology\| PubMed ID: 34256417	2021
Deriving Regionally Specific Biomarkers of Emphysema and Small Airways Disease Using Variable Threshold Parametric Response Mapping on Volumetric Lung CT Images. Academic radiology\| PubMed ID: 34272162	2022
Radial Flow Perfusion Enables Real-Time Profiling of Cellular Metabolism at Low Oxygen Levels with Hyperpolarized C NMR Spectroscopy. Metabolites\| PubMed ID: 34564392	2021
Hyperpolarized Xe MRI of the rat brain with chemical shift saturation recovery and spiral-IDEAL readout. Magnetic resonance in medicine\| PubMed ID: 34841605	2022
Simultaneous Imaging of Ventilation and Gas Exchange with Hyperpolarized Xe MRI for Monitoring Patients with Endobronchial Valve Interventions. American journal of respiratory and critical care medicine\| PubMed ID: 35044897	2022
Imatinib alleviates lung injury and prolongs survival in ventilated rats. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 35438574	2022
Investigating the impact of RF saturation-pulse parameters on compartment-selective gas-phase depolarization with xenon polarization transfer contrast MRI. Magnetic resonance in medicine\| PubMed ID: 36046917	2022
Preclinical MRI Using Hyperpolarized Xe. Molecules (Basel, Switzerland)\| PubMed ID: 36500430	2022
Simultaneous quantification of hyperpolarized xenon-129 ventilation and gas exchange with multi-breath xenon-polarization transfer contrast (XTC) MRI. Magnetic resonance in medicine\| PubMed ID: 37533368	2023