Mariana J. Kaplan

Systemic Autoimmunity Branch, National Institutes of Health (NIH)

Affiliated withNational Institutes of Health (NIH)

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2023

Other Publications

Article	Year
Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis. Circulation research\| PubMed ID: 24425713	2014
Detection of SLE antigens in neutrophil extracellular traps (NETs). Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24497360	2014
Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2. Annals of the rheumatic diseases\| PubMed ID: 24570026	2015
Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24838349	2014
The inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis? Current opinion in rheumatology\| PubMed ID: 24992143	2014
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Annals of the rheumatic diseases\| PubMed ID: 25104775	2014
Interleukin 10 hampers endothelial cell differentiation and enhances the effects of interferon α on lupus endothelial cell progenitors. Rheumatology (Oxford, England)\| PubMed ID: 25416712	2015
Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils. Journal of autoimmunity\| PubMed ID: 25638528	2015
A novel image-based quantitative method for the characterization of NETosis. Journal of immunological methods\| PubMed ID: 26003624	2015
The development of depressive symptoms during medical internship stress predicts worsening vascular function. Journal of psychosomatic research\| PubMed ID: 26115588	2015
The role of neutrophils in the pathogenesis of systemic lupus erythematosus. Current opinion in rheumatology\| PubMed ID: 26125102	2015
Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2. American journal of respiratory and critical care medicine\| PubMed ID: 26417909	2016
At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases. Journal of leukocyte biology\| PubMed ID: 26432901	2016
Severity of Psoriasis Associates With Aortic Vascular Inflammation Detected by FDG PET/CT and Neutrophil Activation in a Prospective Observational Study. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26449753	2015
Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26764034	2016
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nature medicine\| PubMed ID: 26779811	2016
Placental histology and neutrophil extracellular traps in lupus and pre-eclampsia pregnancies. Lupus science & medicine\| PubMed ID: 27158525	2016
Update on cardiovascular disease in lupus. Current opinion in rheumatology\| PubMed ID: 27227346	2016
The role of neutrophils and NETosis in autoimmune and renal diseases. Nature reviews. Nephrology\| PubMed ID: 27241241	2016
Alterations in nuclear structure promote lupus autoimmunity in a mouse model. Disease models & mechanisms\| PubMed ID: 27483354	2016
Dysfunction of endothelial progenitor cells is associated with the type I IFN pathway in patients with polymyositis and dermatomyositis. Rheumatology (Oxford, England)\| PubMed ID: 27498356	2016
Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis. Clinical immunology (Orlando, Fla.)\| PubMed ID: 27519955	2017
Lupus high-density lipoprotein induces proinflammatory responses in macrophages by binding lectin-like oxidised low-density lipoprotein receptor 1 and failing to promote activating transcrip... Annals of the rheumatic diseases\| PubMed ID: 27543414	2017
Disentangling the role of neutrophil extracellular traps in rheumatic diseases. Current opinion in rheumatology\| PubMed ID: 27755122	2017
Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28179497	2017
A role for muscarinic receptors in neutrophil extracellular trap formation and levamisole-induced autoimmunity. JCI insight\| PubMed ID: 28194438	2017
Metabolic abnormalities and oxidative stress in lupus. Current opinion in rheumatology\| PubMed ID: 28639951	2017
Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis. Science immunology\| PubMed ID: 28649674	2017
Unraveling Vascular Inflammation: From Immunology to Imaging. Journal of the American College of Cardiology\| PubMed ID: 28882238	2017
A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29196457	2018
Differential ubiquitination in NETs regulates macrophage responses in systemic lupus erythematosus. Annals of the rheumatic diseases\| PubMed ID: 29588275	2018
Response to comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis". Science immunology\| PubMed ID: 29602804	2018
Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin-2 and neutrophil extracellular traps. Hepatology (Baltimore, Md.)\| PubMed ID: 29633303	2018
Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance. Lupus science & medicine\| PubMed ID: 29765617	2018
Cardiovascular disease in systemic lupus erythematosus: an update. Current opinion in rheumatology\| PubMed ID: 29870498	2018
Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome. Annals of the rheumatic diseases\| PubMed ID: 30131320	2018
Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis. Frontiers in immunology\| PubMed ID: 30140264	2018
Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides. Nature biotechnology\| PubMed ID: 30346940	2018
Genome-wide DNA methylation analysis in primary antiphospholipid syndrome neutrophils. Clinical immunology (Orlando, Fla.)\| PubMed ID: 30471352	2018
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell death and differentiation\| PubMed ID: 30622307	2019
Neutrophils in Rheumatoid Arthritis: Breaking Immune Tolerance and Fueling Disease. Trends in molecular medicine\| PubMed ID: 30709614	2019
Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming. Journal of leukocyte biology\| PubMed ID: 30835869	2019
Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis. JACC. Basic to translational science\| PubMed ID: 30847414	2019
Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2. Blood\| PubMed ID: 31015188	2019
Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus. Annals of the rheumatic diseases\| PubMed ID: 31040119	2019
Response to: 'Neutrophil extracellular traps and low-density granulocytes are associated with the interferon signature in systemic lupus erythematosus, but not in antiphospholipid syndrome' ... Annals of the rheumatic diseases\| PubMed ID: 31272942	2020
Association of lipoprotein subfractions and glycoprotein acetylation with coronary plaque burden in SLE. Lupus science & medicine\| PubMed ID: 31413851	2019
The Role of Neutrophils and Neutrophil Extracellular Traps in Vascular Damage in Systemic Lupus Erythematosus. Journal of clinical medicine\| PubMed ID: 31466329	2019
Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa. Science translational medicine\| PubMed ID: 31484788	2019
NETched in Stone. Immunity\| PubMed ID: 31533050	2019
Deadliest catch: neutrophil extracellular traps in autoimmunity. Current opinion in rheumatology\| PubMed ID: 31644465	2020
Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31754025	2019
NETs spread ever wider in rheumatic diseases. Nature reviews. Rheumatology\| PubMed ID: 31853047	2020
The mechanics of myeloid cells. Biology of the cell\| PubMed ID: 31916263	2020
Of larks and owls. Nature immunology\| PubMed ID: 31932811	2020
Technical comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis". Science immunology\| PubMed ID: 32005680	2020
Erratum for Research Article "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis" by C. Carmona-Rivera, P. M. Carlucci, E. Moore, N. Lin... Science immunology\| PubMed ID: 32005681	2020
Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32094169	2020
Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus. Scientific reports\| PubMed ID: 32157125	2020
Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells. Immunity\| PubMed ID: 32187519	2020
Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL- mice. Lupus science & medicine\| PubMed ID: 32343673	2020
Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32541026	2020
Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32601182	2020
Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome. The Journal of allergy and clinical immunology\| PubMed ID: 32768442	2021
Immunometabolism in the pathogenesis of systemic lupus erythematosus: an update. Current opinion in rheumatology\| PubMed ID: 32826478	2020
Proteomic, biomechanical and functional analyses define neutrophil heterogeneity in systemic lupus erythematosus. Annals of the rheumatic diseases\| PubMed ID: 32988843	2021
Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model. Frontiers in immunology\| PubMed ID: 33072095	2020
Somatic Mutations in and Severe Adult-Onset Autoinflammatory Disease. The New England journal of medicine\| PubMed ID: 33108101	2020
Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis. Science advances\| PubMed ID: 33115748	2020
Neutrophils in the Pathogenesis of Rheumatic Diseases: Fueling the Fire. Clinical reviews in allergy & immunology\| PubMed ID: 33155144	2021
Association between anti-interferon-alpha autoantibodies and COVID-19 in systemic lupus erythematosus. medRxiv : the preprint server for health sciences\| PubMed ID: 33184616	2020
Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine'. Annals of the rheumatic diseases\| PubMed ID: 33452005	2023
Linking clotting and autoimmunity. Science (New York, N.Y.)\| PubMed ID: 33707252	2021
Interferon lambda in inflammation and autoimmune rheumatic diseases. Nature reviews. Rheumatology\| PubMed ID: 33907323	2021
Cholesterol-Induced M4-Like Macrophages Recruit Neutrophils and Induce NETosis. Frontiers in immunology\| PubMed ID: 34012454	2021
Patients with COVID-19: in the dark-NETs of neutrophils. Cell death and differentiation\| PubMed ID: 34031543	2021
Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus. Nature communications\| PubMed ID: 34099646	2021
Neutrophil Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus. Rheumatic diseases clinics of North America\| PubMed ID: 34215366	2021
Neutrophils as Drivers of Immune Dysregulation in Autoimmune Diseases with Skin Manifestations. The Journal of investigative dermatology\| PubMed ID: 34253374	2022
Anti-Carbamylated LL37 Antibodies Promote Pathogenic Bone Resorption in Rheumatoid Arthritis. Frontiers in immunology\| PubMed ID: 34594331	2021
Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages. The Journal of investigative dermatology\| PubMed ID: 34606886	2022
Mitochondrial dysfunction in the erythroid compartment. Nature immunology\| PubMed ID: 34671144	2021
Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19. medRxiv : the preprint server for health sciences\| PubMed ID: 35262093	2022
Cardiovascular disease risk and pathogenesis in systemic lupus erythematosus. Seminars in immunopathology\| PubMed ID: 35355124	2022
Diseases of blood vessels: Immune system involvement in vasculitis and vasculopathy. Seminars in immunopathology\| PubMed ID: 35503576	2022
Neutrophil phenotypes and functions in cancer: A consensus statement. The Journal of experimental medicine\| PubMed ID: 35522219	2022
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers. EMBO reports\| PubMed ID: 35856334	2022
Single-Cell Analysis Reveals the Range of Transcriptional States of Circulating Human Neutrophils. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 35858733	2022
Peroxisome proliferator activated receptor-γ agonist pioglitazone improves vascular and metabolic dysfunction in systemic lupus erythematosus. Annals of the rheumatic diseases\| PubMed ID: 35914929	2022
Neutralizing Anti‒DNase 1 and ‒DNase 1L3 Antibodies Impair Neutrophil Extracellular Traps Degradation in Hidradenitis Suppurativa. The Journal of investigative dermatology\| PubMed ID: 35934056	2023
Coexisting autoantibodies against transcription factor Sp4 are associated with decreased cancer risk in patients with dermatomyositis with anti-TIF1γ autoantibodies. Annals of the rheumatic diseases\| PubMed ID: 36008132	2023
Quantification of Neutrophils Undergoing NET Formation and Distinguishing Mechanisms of Neutrophil Cell Death by Use of a High-Throughput Method. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 36087264	2022
Casting a Wide NET. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 36130128	2022
Changes in cardiorespiratory function and fatigue following 12 weeks of exercise training in women with systemic lupus erythematosus: a pilot study. Lupus science & medicine\| PubMed ID: 36220328	2022
Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. Nature reviews. Immunology\| PubMed ID: 36257987	2023
Low-density granulocytes in systemic autoimmunity and autoinflammation. Immunological reviews\| PubMed ID: 36305174	2023
Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis. JCI insight\| PubMed ID: 36345939	2022
Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19. Science advances\| PubMed ID: 36598976	2023
Neutrophil extracellular trap-associated carbamylation and histones trigger osteoclast formation in rheumatoid arthritis. Annals of the rheumatic diseases\| PubMed ID: 36737106	2023
Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome. Nature communications\| PubMed ID: 36932076	2023
Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway. Nature cancer\| PubMed ID: 36973439	2023
Metabolic alterations of the immune system in the pathogenesis of autoimmune diseases. PLoS biology\| PubMed ID: 37098006	2023
Transmission disequilibrium analysis of whole genome data in childhood-onset systemic lupus erythematosus. Genes and immunity\| PubMed ID: 37488248	2023
Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's Disease. medRxiv : the preprint server for health sciences\| PubMed ID: 37662351	2023