Sangeeta N. Bhatia

Institute for Medical Engineering and Science, Massachusetts Institute of Technology

Affiliated withMassachusetts Institute of Technology Howard Hughes Medical Institute Broad Institute of Massachusetts Institute of Technology and Harvard

Research Area

Bioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2023

Other Publications

Article	Year
Quantum dots to monitor RNAi delivery and improve gene silencing. Nucleic acids research\| PubMed ID: 16352864	2005
Proteolytic actuation of nanoparticle self-assembly. Angewandte Chemie (International ed. in English)\| PubMed ID: 16642514	2006
Local heating of discrete droplets using magnetic porous silicon-based photonic crystals. Journal of the American Chemical Society\| PubMed ID: 16771508	2006
Engineering tissues for in vitro applications. Current opinion in biotechnology\| PubMed ID: 16978857	2006
Assessment of hepatocellular function within PEG hydrogels. Biomaterials\| PubMed ID: 16979755	2007
Microscale control of cell contact and spacing via three-component surface patterning. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 17243746	2007
Micromechanical control of cell-cell interactions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17389399	2007
Multiphase electropatterning of cells and biomaterials. Lab on a chip\| PubMed ID: 17538711	2007
High-throughput analysis of signals regulating stem cell fate and function. Current opinion in chemical biology\| PubMed ID: 17656147	2007
Microscale culture of human liver cells for drug development. Nature biotechnology\| PubMed ID: 18026090	2008
T-cadherin modulates hepatocyte functions in vitro. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18635739	2008
Protease-triggered unveiling of bioactive nanoparticles. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18690639	2008
Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery. Angewandte Chemie (International ed. in English)\| PubMed ID: 18696519	2008
Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers. Biomaterials\| PubMed ID: 19046762	2009
Statistical dynamics of flowing red blood cells by morphological image processing. PLoS computational biology\| PubMed ID: 19214200	2009
Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nature materials\| PubMed ID: 19234444	2009
Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 19263431	2009
Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer research\| PubMed ID: 19366797	2009
Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology (Baltimore, Md.)\| PubMed ID: 19585615	2009
Tissue-specific gene delivery via nanoparticle coating. Biomaterials\| PubMed ID: 19850333	2010
Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents. ACS nano\| PubMed ID: 19950973	2009
Cooperative nanomaterial system to sensitize, target, and treat tumors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080556	2010
Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nature biotechnology\| PubMed ID: 20118917	2010
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133632	2010
SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 20174478	2009
Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 20217810	2010
Targeting of drugs and nanoparticles to tumors. The Journal of cell biology\| PubMed ID: 20231381	2010
Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20532320	2010
Single cell trapping and DNA damage analysis using microwell arrays. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20534572	2010
Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting. Angewandte Chemie (International ed. in English)\| PubMed ID: 20740515	2010
Multiplexed, high-throughput analysis of 3D microtissue suspensions. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20820630	2010
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21187397	2011
In-silico patterning of vascular mesenchymal cells in three dimensions. PloS one\| PubMed ID: 21633504	2011
Nanoparticles that communicate in vivo to amplify tumour targeting. Nature materials\| PubMed ID: 21685903	2011
Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 21687830	2008
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21746896	2011
Humanized mice with ectopic artificial liver tissues. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21746904	2011
DNA-templated assembly of droplet-derived PEG microtissues. Lab on a chip\| PubMed ID: 21776518	2011
Modeling hepatitis C virus infection using human induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308485	2012
A biophysical indicator of vaso-occlusive risk in sickle cell disease. Science translational medicine\| PubMed ID: 22378926	2012
Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nature materials\| PubMed ID: 22751181	2012
Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Science translational medicine\| PubMed ID: 22896676	2012
Cancer vulnerabilities unveiled by genomic loss. Cell\| PubMed ID: 22901813	2012
Identification and characterization of receptor-specific peptides for siRNA delivery. ACS nano\| PubMed ID: 22909216	2012
Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23033492	2012
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature communications\| PubMed ID: 23047680	2012
Bioengineering methods for analysis of cells in vitro. Annual review of cell and developmental biology\| PubMed ID: 23057744	2012
Genetic Circuits in Salmonella typhimurium. ACS synthetic biology\| PubMed ID: 23097749	2012
In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria. ACS synthetic biology\| PubMed ID: 23097750	2012
Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nature biotechnology\| PubMed ID: 23242163	2013
Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Lab on a chip\| PubMed ID: 23563587	2013
Geometric control of vascular networks to enhance engineered tissue integration and function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23610423	2013
Mitochondrial localization and the persistent migration of epithelial cancer cells. Biophysical journal\| PubMed ID: 23663851	2013
Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology\| PubMed ID: 23728495	2013
A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. Cell host & microbe\| PubMed ID: 23870318	2013
Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source. ACS nano\| PubMed ID: 23961973	2013
Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis. ACS nano\| PubMed ID: 24015809	2013
Nanotechnology: emerging tools for biology and medicine. Genes & development\| PubMed ID: 24240230	2013
Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro. Disease models & mechanisms\| PubMed ID: 24291761	2014
Weighing nanoparticles in solution at the attogram scale. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24474753	2014
Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Tissue engineering. Part A\| PubMed ID: 24498910	2014
Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24567404	2014
A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors. Nano today\| PubMed ID: 25009578	2013
Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology. Trends in biotechnology\| PubMed ID: 25086728	2014
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25092305	2014
Microfluidic organs-on-chips. Nature biotechnology\| PubMed ID: 25093883	2014
Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade. ACS nano\| PubMed ID: 25119520	2014
Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers. Journal of the American Chemical Society\| PubMed ID: 25198059	2014
Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25214538	2014
Patterning vascular networks in vivo for tissue engineering applications. Tissue engineering. Part C, Methods\| PubMed ID: 25390971	2015
In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection. Eukaryotic cell\| PubMed ID: 25416236	2015
Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche. Cancer discovery\| PubMed ID: 25421439	2015
Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection. Cell host & microbe\| PubMed ID: 25498345	2014
Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro. Stem cell reports\| PubMed ID: 25660406	2015
Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering. Journal of biomedical materials research. Part A\| PubMed ID: 25851120	2015
New Methods in Tissue Engineering: Improved Models for Viral Infection. Annual review of virology\| PubMed ID: 25893203	2014
Programmable probiotics for detection of cancer in urine. Science translational medicine\| PubMed ID: 26019220	2015
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus. Scientific reports\| PubMed ID: 26035283	2015
Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors. Cancer research\| PubMed ID: 26122846	2015
A Macro-to-Micro Interface for the Control of Cellular Organization. Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems\| PubMed ID: 26167106	2014
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Science translational medicine\| PubMed ID: 26180101	2015
Mathematical framework for activity-based cancer biomarkers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26417077	2015
Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity. ACS nano\| PubMed ID: 26565752	2015
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens. Nature protocols\| PubMed ID: 26584444	2015
Smart nanosystems: Bio-inspired technologies that interact with the host environment. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26598694	2015
Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies. Virology\| PubMed ID: 27128351	2016
Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 27383373	2016
Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries. ACS nano\| PubMed ID: 27429164	2016
Synchronized cycles of bacterial lysis for in vivo delivery. Nature\| PubMed ID: 27437587	2016
Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. International journal for parasitology\| PubMed ID: 27456552	2016
Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors. Angewandte Chemie (International ed. in English)\| PubMed ID: 27554600	2016
Host AMPK Is a Modulator of Plasmodium Liver Infection. Cell reports\| PubMed ID: 27568570	2016
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature\| PubMed ID: 27602946	2016
Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling. Nano letters\| PubMed ID: 27622711	2016
Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers. Scientific reports\| PubMed ID: 28361899	2017
Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 28699173	2017
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease. Science translational medicine\| PubMed ID: 28724577	2017
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science (New York, N.Y.)\| PubMed ID: 28912244	2017
Ultrasensitive tumour-penetrating nanosensors of protease activity. Nature biomedical engineering\| PubMed ID: 28970963	2017
Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas. Scientific reports\| PubMed ID: 29018206	2017
A robust cell culture system supporting the complete life cycle of hepatitis B virus. Scientific reports\| PubMed ID: 29192196	2017
Depolarization signatures map gold nanorods within biological tissue. Nature photonics\| PubMed ID: 29201136	2017
Engineered Livers for Infectious Diseases. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 29322086	2018
Personalized RNA Medicine for Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 29330203	2018
In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites. Cell host & microbe\| PubMed ID: 29478773	2018
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nature medicine\| PubMed ID: 29554083	2018
Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts. Advanced functional materials\| PubMed ID: 29706854	2016
Drug-induced amplification of nanoparticle targeting to tumors. Nano today\| PubMed ID: 29731806	2014
Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain. Nanoscale horizons\| PubMed ID: 29732165	2016
Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29736708	2018
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nature genetics\| PubMed ID: 29955178	2018
iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer. Molecular cancer therapeutics\| PubMed ID: 30097486	2018
Classification of prostate cancer using a protease activity nanosensor library. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30126988	2018
A sporozoite-based vaccination platform against human malaria. NPJ vaccines\| PubMed ID: 30155278	2018
Protease activity sensors noninvasively classify bacterial infections and antibiotic responses. EBioMedicine\| PubMed ID: 30503861	2018
Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nature medicine\| PubMed ID: 30552419	2019
Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocyte... Gastroenterology\| PubMed ID: 30641053	2019
Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes. Cancer research\| PubMed ID: 30755444	2019
Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers. Cell metabolism\| PubMed ID: 30840913	2019
Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles. Cell\| PubMed ID: 30929905	2019
Antimalarial activity of primaquine operates via a two-step biochemical relay. Nature communications\| PubMed ID: 31324806	2019
Renal clearable catalytic gold nanoclusters for in vivo disease monitoring. Nature nanotechnology\| PubMed ID: 31477801	2019
Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer. Oncotarget\| PubMed ID: 31523393	2019
Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes. Nanoscale\| PubMed ID: 31670340	2019
Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing. Angewandte Chemie (International ed. in English)\| PubMed ID: 31747099	2020
Targeting liver stage malaria with metformin. JCI insight\| PubMed ID: 31852843	2019
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31915293	2020
Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging. ACS synthetic biology\| PubMed ID: 31922737	2020
Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma. Cancer research\| PubMed ID: 32029550	2020
Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling. Science translational medicine\| PubMed ID: 32238573	2020
Activity-Based Diagnostics: An Emerging Paradigm for Disease Detection and Monitoring. Trends in molecular medicine\| PubMed ID: 32359477	2020
Pharmacokinetic tuning of protein-antigen fusions enhances the immunogenicity of T-cell vaccines. Nature biomedical engineering\| PubMed ID: 32483299	2020
Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32493746	2020
Engineering synthetic breath biomarkers for respiratory disease. Nature nanotechnology\| PubMed ID: 32690884	2020
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination. Science translational medicine\| PubMed ID: 32718991	2020
Peptide Spiders: Peptide-Polymer Conjugates to Traffic Nucleic Acids. Molecular pharmaceutics\| PubMed ID: 32786959	2020
Activatable Zymography Probes Enable Localization of Protease Dysregulation in Cancer. Cancer research\| PubMed ID: 33106334	2021
Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues. Advanced functional materials\| PubMed ID: 33613149	2020
Selective Permeabilization of Gram-Negative Bacterial Membranes Using Multivalent Peptide Constructs for Antibiotic Sensitization. ACS infectious diseases\| PubMed ID: 33689277	2021
Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers. Advanced functional materials\| PubMed ID: 33776613	2020
Opening the path to biotech. Science (New York, N.Y.)\| PubMed ID: 33958450	2021
Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Nature\| PubMed ID: 34194041	2021
Microenvironment-triggered multimodal precision diagnostics. Nature materials\| PubMed ID: 34267368	2021
Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function. ACS chemical biology\| PubMed ID: 34427427	2021
Synthetic Circuit-Driven Expression of Heterologous Enzymes for Disease Detection. ACS synthetic biology\| PubMed ID: 34464083	2021
Synthetic biomarkers: a twenty-first century path to early cancer detection. Nature reviews. Cancer\| PubMed ID: 34489588	2021
Distinct Hepatic Gene-Expression Patterns of NAFLD in Patients With Obesity. Hepatology communications\| PubMed ID: 34558849	2022
Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis. The European respiratory journal\| PubMed ID: 34561286	2022
Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 34786888	2022
Ionic Liquid-Mediated Transdermal Delivery of Thrombosis-Detecting Nanosensors. Advanced healthcare materials\| PubMed ID: 35182107	2022
Virtual Undergraduate Research Experiences: More Than a Pandemic Stopgap. Med (New York, N.Y.)\| PubMed ID: 35187514	2021
A single-cell liver atlas of Plasmodium vivax infection. Cell host & microbe\| PubMed ID: 35443155	2022
Host protease activity classifies pneumonia etiology. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35696579	2022
A vascularized model of the human liver mimics regenerative responses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35763565	2022
Cancer nanomedicine. Nature reviews. Cancer\| PubMed ID: 35941223	2022
Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer. Cell reports methods\| PubMed ID: 35942328	2022
Conditional Antimicrobial Peptide Therapeutics. ACS nano\| PubMed ID: 35980829	2022
Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes. Stem cell reports\| PubMed ID: 36084636	2022
Multiscale profiling of protease activity in cancer. Nature communications\| PubMed ID: 36192379	2022
Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science (New York, N.Y.)\| PubMed ID: 36701450	2023
CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics. Nature nanotechnology\| PubMed ID: 37095220	2023
Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer. Nature communications\| PubMed ID: 37463915	2023