Babu L. Tekwani

National Center for Natural Products Research, University of Mississippi

Affiliated withUniversity of Mississippi

Research Area

Biography

Babu L. Tekwani has not added Biography.
If you are Babu L. Tekwani and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 117	2012

Other Publications

Article	Year
A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite. Biochemical and biophysical research communications\| PubMed ID: 11779214	2002
Peripheral blood leucocytes ornithine decarboxylase activity in chronic myeloid leukemia patients: prognostic and therapeutic implications. Leukemia research\| PubMed ID: 11839377	2002
Haem polymerase as a novel target of antimalarial action of cyproheptadine. Biochemical pharmacology\| PubMed ID: 12392821	2002
Synthesis and biological evaluation of new imidazo[1,2-a]pyridine derivatives designed as mefloquine analogues. Farmaco (SocietÃ chimica italiana : 1989)\| PubMed ID: 12420878	2002
A novel active DNA topoisomerase I in Leishmania donovani. The Journal of biological chemistry\| PubMed ID: 12444094	2003
Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorum. Journal of natural products\| PubMed ID: 12828466	2003
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. Journal of natural products\| PubMed ID: 12828469	2003
Flow cytometric analysis of aneuploidy and S-phase fraction in chronic myeloid leukemia patients: role in early detection of accelerated phase. Leukemia research\| PubMed ID: 12860009	2003
Antiparasitic alkaloids from Psychotria klugii. Journal of natural products\| PubMed ID: 12880315	2003
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and ma... Journal of medicinal chemistry\| PubMed ID: 13678403	2003
Molecular and functional characterization of adenylate kinase 2 gene from Leishmania donovani. European journal of biochemistry / FEBS\| PubMed ID: 14622299	2003
Spectrophotometric determination of de novo hemozoin/beta-hematin formation in an in vitro assay. Analytical biochemistry\| PubMed ID: 14715288	2004
Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors. Antimicrobial agents and chemotherapy\| PubMed ID: 15047563	2004
A new antimalarial quassinoid from Simaba orinocensis. Journal of natural products\| PubMed ID: 15165136	2004
Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents. European journal of medicinal chemistry\| PubMed ID: 15183913	2004
An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme. European journal of biochemistry / FEBS\| PubMed ID: 15317584	2004
Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases. Journal of natural products\| PubMed ID: 15332848	2004
Antimicrobial and antileishmanial activities of hypocrellins A and B. Antimicrobial agents and chemotherapy\| PubMed ID: 15504880	2004
Targeting the hemozoin synthesis pathway for new antimalarial drug discovery: technologies for in vitro beta-hematin formation assay. Combinatorial chemistry & high throughput screening\| PubMed ID: 15720198	2005
Bisnortriterpenes from Salacia madagascariensis. Journal of natural products\| PubMed ID: 15730255	2005
Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues. Bioorganic & medicinal chemistry\| PubMed ID: 15878667	2005
Polyamine transport in parasites: a potential target for new antiparasitic drug development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP\| PubMed ID: 15907761	2005
Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues. Bioorganic & medicinal chemistry\| PubMed ID: 16274995	2006
Aromatic constituents of Uvaria grandiflora. Journal of natural products\| PubMed ID: 16643056	2006
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases. Journal of natural products\| PubMed ID: 16872140	2006
Anti-plasmodial and anti-leishmanial activity of conformationally restricted pentamidine congeners. The Journal of pharmacy and pharmacology\| PubMed ID: 16872549	2006
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols. Bioorganic & medicinal chemistry\| PubMed ID: 17070063	2007
8-Aminoquinolines: future role as antiprotozoal drugs. Current opinion in infectious diseases\| PubMed ID: 17075340	2006
Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines. Bioorganic & medicinal chemistry\| PubMed ID: 17084633	2007
A new library of C-16 modified artemisinin analogs and evaluation of their anti-parasitic activities. Combinatorial chemistry & high throughput screening\| PubMed ID: 17168678	2006
Synthesis of isoquinuclidine analogs of chloroquine: antimalarial and antileishmanial activity. Bioorganic & medicinal chemistry\| PubMed ID: 17400457	2007
Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. Journal of medicinal chemistry\| PubMed ID: 17636950	2007
Antileishmanial, antiplasmodial and cytotoxic activities of 12,16-dideoxy aegyptinone B from Zhumeria majdae Rech.f. & Wendelbo. Phytotherapy research : PTR\| PubMed ID: 17886231	2008
S-Euglobals: biomimetic synthesis, antileishmanial, antimalarial, and antimicrobial activities. Bioorganic & medicinal chemistry\| PubMed ID: 17976995	2008
Growth, drug susceptibility, and gene expression profiling of Plasmodium falciparum cultured in medium supplemented with human serum or lipid-rich bovine serum albumin [corrected]. Journal of biomolecular screening\| PubMed ID: 18087074	2007
Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy. Bioorganic & medicinal chemistry\| PubMed ID: 18362073	2008
Novel bisbenzimidazoles with antileishmanial effectiveness. Bioorganic & medicinal chemistry letters\| PubMed ID: 18367395	2008
Probing the structures of leishmanial farnesyl pyrophosphate synthases: homology modeling and docking studies. Journal of chemical information and modeling\| PubMed ID: 18419114	2008
Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. Infectious disorders drug targets\| PubMed ID: 18473904	2008
Infectious disorders drug targets--an arsenal of knowledge on pathogen targets. Infectious disorders drug targets\| PubMed ID: 18473906	2008
Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides. Bioorganic & medicinal chemistry\| PubMed ID: 18571927	2008
Kinetic studies and bioactivity of potential manzamine prodrugs. Journal of natural products\| PubMed ID: 18598080	2008
Current antiparasitic drug targets and a paradigm shift in discovery of new antiparasitic drugs and vaccines. Current drug targets\| PubMed ID: 18991603	2008
Plasmodium falciparum serine/threonine phoshoprotein phosphatases (PPP): from housekeeper to the 'holy grail'. Current drug targets\| PubMed ID: 18991611	2008
Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. Phytotherapy research : PTR\| PubMed ID: 19067375	2008
Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa. Journal of natural products\| PubMed ID: 19105653	2009
Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs. Antimicrobial agents and chemotherapy\| PubMed ID: 19171802	2009
Analysis of quaternary structure of a [LDH-like] malate dehydrogenase of Plasmodium falciparum with oligomeric mutants. Molecular and cellular biochemistry\| PubMed ID: 19184366	2009
Bioactive (+)-manzamine A and (+)-8-hydroxymanzamine A tertiary bases and salts from Acanthostrongylophora ingens and their preparations. Natural product communications\| PubMed ID: 19370920	2009
Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes. Toxicology and applied pharmacology\| PubMed ID: 19616568	2009
Antimicrobial, antiparasitic and cytotoxic spermine alkaloids from Albizia schimperiana. Natural product communications\| PubMed ID: 19634324	2009
Structure and function of Plasmodium falciparum malate dehydrogenase: role of critical amino acids in co-substrate binding pocket. Biochimie\| PubMed ID: 19772885	2009
Structure-activity relationship studies of manzamine A: amidation of positions 6 and 8 of the beta-carboline moiety. Bioorganic & medicinal chemistry\| PubMed ID: 19833520	2009
Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers. Bioorganic & medicinal chemistry\| PubMed ID: 19879765	2009
Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson's disease. Journal of ethnopharmacology\| PubMed ID: 19879939	2010
Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group. Bioorganic & medicinal chemistry\| PubMed ID: 19914074	2010
Biologically active tetranorditerpenoids from the fungus Sclerotinia homoeocarpa causal agent of dollar spot in turfgrass. Journal of natural products\| PubMed ID: 19928902	2009
Cytochrome P450-dependent toxicity of dapsone in human erythrocytes. Journal of applied toxicology : JAT\| PubMed ID: 19998329	2010
Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. Journal of medicinal chemistry\| PubMed ID: 20017491	2010
Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's disease. Journal of ethnopharmacology\| PubMed ID: 20219660	2010
Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia. Journal of natural products\| PubMed ID: 20337497	2010
A structure-activity relationship study of the antimalarial and antileishmanial activities of nonpeptide macrocyclic histone deacetylase inhibitors. ChemMedChem\| PubMed ID: 20533500	2010
Antimicrobial and antiparasitic abietane diterpenoids from the roots of Clerodendrum eriophyllum. Natural product communications\| PubMed ID: 20614808	2010
Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton. Journal of medicinal chemistry\| PubMed ID: 20669972	2010
The antiplasmodial activity of norcantharidin analogs. Bioorganic & medicinal chemistry letters\| PubMed ID: 20888768	2010
Analysis of primaquine and its metabolite carboxyprimaquine in biological samples: enantiomeric separation, method validation and quantification. Biomedical chromatography : BMC\| PubMed ID: 21058417	2011
Synthesis, antiprotozoal, antimicrobial, Î²-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines). Bioorganic & medicinal chemistry\| PubMed ID: 21172735	2011
Antiparasitic and antimicrobial indolizidines from the leaves of Prosopis glandulosa var. glandulosa. Planta medica\| PubMed ID: 21384317	2011
Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library. Journal of chemical information and modeling\| PubMed ID: 21428453	2011
An entry to curcuphenol/elvirol core structures via a retro-Aldol reaction. Chemistry & biodiversity\| PubMed ID: 21674782	2011
Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi. Natural product communications\| PubMed ID: 22224279	2011
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines. Bioorganic & medicinal chemistry letters\| PubMed ID: 22248858	2012
Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs. Bioorganic & medicinal chemistry letters\| PubMed ID: 22264472	2012
Understanding the mechanisms for metabolism-linked hemolytic toxicity of primaquine against glucose 6-phosphate dehydrogenase deficient human erythrocytes: evaluation of eryptotic pathway. Toxicology\| PubMed ID: 22330256	2012
Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: synthesis and evaluation of anti-infective, Î²-haematin inhibition and cytotoxic activities. European journal of medicinal chemistry\| PubMed ID: 22483965	2012
Antiprotozoal and antimicrobial compounds from the plant pathogen Septoria pistaciarum. Journal of natural products\| PubMed ID: 22530813	2012
Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal and anti-HIV activities. Chemical biology & drug design\| PubMed ID: 22703590	2012
Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B. Bioorganic & medicinal chemistry letters\| PubMed ID: 22781190	2012
Pentacyclic ingamine alkaloids, a new antiplasmodial pharmacophore from the marine sponge Petrosid Ng5 Sp5. Planta medica\| PubMed ID: 22903383	2012
Synthesis and Structure-Activity Relationships of Lansine Analogues as Antileishmanial Agents. ChemMedChem\| PubMed ID: 22987791	2012
Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens. Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents\| PubMed ID: 23024574	2012
Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus. Natural product communications\| PubMed ID: 23074885	2012