Elizabeth M. Jaffee

The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine

Affiliated withThe Johns Hopkins University School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 43	2013

Other Publications

Article	Year
Cytokine gene-modified cell-based cancer vaccines. Methods in molecular medicine\| PubMed ID: 11987781	2002
Focus on pancreas cancer. Cancer cell\| PubMed ID: 12150822	2002
Pancreatic cancer. Current problems in cancer\| PubMed ID: 12399802	2002
To live or not to live: that depends on GAGE? Cancer biology & therapy\| PubMed ID: 12432252	2002
Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo. International journal of cancer. Journal international du cancer\| PubMed ID: 12455034	2003
Cytokine modified tumor vaccines. Surgical oncology clinics of North America\| PubMed ID: 12487062	2002
Identification and characterization of the immunodominant rat HER-2/neu MHC class I epitope presented by spontaneous mammary tumors from HER-2/neu-transgenic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12682262	2003
Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy. European journal of immunology\| PubMed ID: 12731050	2003
Lentivirus-mediated gene transfer and expression in established human tumor antigen-specific cytotoxic T cells and primary unstimulated T cells. Human gene therapy\| PubMed ID: 12885348	2003
HER-2/neu-specific monoclonal antibodies collaborate with HER-2/neu-targeted granulocyte macrophage colony-stimulating factor secreting whole cell vaccination to augment CD8+ T cell effector... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12902523	2003
Cancer vaccines: an old idea comes of age. Cancer biology & therapy\| PubMed ID: 14508095	2003
Toward a breast cancer vaccine: work in progress. Oncology (Williston Park, N.Y.)\| PubMed ID: 14569849	2003
Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. The Journal of experimental medicine\| PubMed ID: 15289501	2004
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. Oncogene\| PubMed ID: 15489885	2005
Development of a cytokine-modified allogeneic whole cell pancreatic cancer vaccine. Methods in molecular medicine\| PubMed ID: 15542914	2005
Augmenting the potency of breast cancer vaccines: combined modality immunotherapy. Breast disease\| PubMed ID: 15687703	2004
Tumor-specific CD4+ T cells from a patient with renal cell carcinoma recognize diverse shared antigens. International journal of cancer. Journal international du cancer\| PubMed ID: 15704175	2005
Diverse CD8+ T-cell responses to renal cell carcinoma antigens in patients treated with an autologous granulocyte-macrophage colony-stimulating factor gene-transduced renal tumor cell vaccin... Cancer research\| PubMed ID: 15705910	2005
Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response. The Journal of experimental medicine\| PubMed ID: 15883172	2005
Immunotherapy for pancreatic cancer - science driving clinical progress. Nature reviews. Cancer\| PubMed ID: 15905855	2005
Allergies and the risk of pancreatic cancer: a meta-analysis with review of epidemiology and biological mechanisms. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 16103436	2005
Fusion to Listeriolysin O and delivery by Listeria monocytogenes enhances the immunogenicity of HER-2/neu and reveals subdominant epitopes in the FVB/N mouse. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16148111	2005
Leveraging the activity of tumor vaccines with cytotoxic chemotherapy. Cancer research\| PubMed ID: 16166275	2005
Cancer vaccines in combination with multimodality therapy. Cancer treatment and research\| PubMed ID: 16211873	2005
Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology. Molecular cancer therapeutics\| PubMed ID: 16275985	2005
OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16393983	2006
Cancer immunologists and cancer biologists: why we didn't talk then but need to now. Cancer research\| PubMed ID: 17413003	2007
A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17606729	2007
Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice. Vaccine\| PubMed ID: 17675184	2007
Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a Pre-Barrett's esophagus setting. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract\| PubMed ID: 17957441	2008
Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18056201	2007
Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin. Cancer immunity\| PubMed ID: 18088084	2007
Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a post-Barrett's esophagus setting. Digestive diseases and sciences\| PubMed ID: 18343998	2008
Antibody association with HER-2/neu-targeted vaccine enhances CD8 T cell responses in mice through Fc-mediated activation of DCs. The Journal of clinical investigation\| PubMed ID: 18398507	2008
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (New York, N.Y.)\| PubMed ID: 18772397	2008
Use of tumour-responsive T cells as cancer treatment. Lancet\| PubMed ID: 19231634	2009
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science (New York, N.Y.)\| PubMed ID: 19264984	2009
Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer research\| PubMed ID: 19351817	2009
OX40 costimulation can abrogate Foxp3+ regulatory T cell-mediated suppression of antitumor immunity. International journal of cancer. Journal international du cancer\| PubMed ID: 19455675	2009
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19584151	2009
Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte-macrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging ... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 19805669	2009
Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice. Cellular immunology\| PubMed ID: 20346445	2010
Effective depletion of regulatory T cells allows the recruitment of mesothelin-specific CD8 T cells to the antitumor immune response against a mesothelin-expressing mouse pancreatic adenocar... Clinical and translational science\| PubMed ID: 20357913	2008
Cellular vaccine approaches. Cancer journal (Sudbury, Mass.)\| PubMed ID: 20693840	2010
Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 20697078	2010
CD8âº Foxp3âº tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response. International journal of cancer. Journal international du cancer\| PubMed ID: 20857491	2011
Nondominant CD8 T cells are active players in the vaccine-induced antitumor immune response. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21346233	2011
Review of the 25th annual scientific meeting of the International Society for Biological Therapy of Cancer. Journal of translational medicine\| PubMed ID: 21569425	2011
Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. PloS one\| PubMed ID: 21572519	2011
Increased expression of DNA repair genes in invasive human pancreatic cancer cells. Pancreas\| PubMed ID: 21633318	2011
A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22147941	2012
Defining the critical hurdles in cancer immunotherapy. Journal of translational medicine\| PubMed ID: 22168571	2011
Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells. PloS one\| PubMed ID: 22359647	2012
The determinants of tumour immunogenicity. Nature reviews. Cancer\| PubMed ID: 22378190	2012
Development of a novel preclinical pancreatic cancer research model: bioluminescence image-guided focal irradiation and tumor monitoring of orthotopic xenografts. Translational oncology\| PubMed ID: 22496923	2012
Whole cell vaccines--past progress and future strategies. Seminars in oncology\| PubMed ID: 22595050	2012
Annexin A2 is a new antigenic target for pancreatic cancer immunotherapy. Oncoimmunology\| PubMed ID: 22720228	2012
Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective. Cancer research\| PubMed ID: 22761338	2012
Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer. Cancer research\| PubMed ID: 22773664	2012
Targeting the right regulatory T-cell population for tumor immunotherapy. Oncoimmunology\| PubMed ID: 23170276	2012
Vaccines for pancreatic cancer. Cancer journal (Sudbury, Mass.)\| PubMed ID: 23187853	2012