roller-microneedle-combined-with-tranexamic-acid-solution-treating

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective ...

Chongqing Hospital of Traditional Chinese Medicine

The risk of recurrence after successful repigmentation in vitiligo has attracted attention from both patients and clinicians.

Recurrence and risk factors in cured patients with vitiligo: A real-life single-center retrospective study.

Limonoids are a class of oxygenated terpenoids that exist mainly in citrus fruits. As a kind of limonoid, obacunone has attracted more and more researchers' attention because of its extensive pharmacological activities. The purpose of the narrative review is to systematically review relevant studies on the pharmacological effects and pharmacokinetic characteristics of obacunone to provide researchers with the latest and useful information. Pharmacological studies have shown that obacunone has a variety of pharmacological activities, such as anticancer, antioxidant, anti-inflammatory, anti-diabetes, neuroprotection, antibiosis, and antivirus. Among them, the anticancer effect is the most prominent. Pharmacokinetic studies have shown that the oral bioavailability of obacunone is low. This indicates the presence of high first-pass metabolism. We hope that this paper can help relevant scholars understand the progress in pharmacological and pharmacokinetic research of obacunone and help the further development of obacunone as a functional food.

Article	Year
Recurrence and risk factors in cured patients with vitiligo: A real-life single-center retrospective study. Journal of cosmetic dermatology\| PubMed ID: 36721299	2023
The pharmacological and pharmacokinetic properties of obacunone from citrus fruits: A comprehensive narrative review. Fitoterapia\| PubMed ID: 37315716	2023

Wenhao Zheng

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