t4-bacteriophage-e-coli-interaction-murine-intestine-prototypical

T4 Bacteriophage and <i>E. coli</i> Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo

Bacteriophages (phages) are viruses that infect bacteria with species- and strain-level specificity and are the most abundant biological entities across ...

University of British Columbia

Using a Stroop task switching paradigm, Brown and Marsden [Brain 111 (1988) 323; Brain 114 (1991) 215] proposed that set shifting deficits in Parkinson's disease (PD) reflect limited attentional resources rather than deficits in internal control, as was previously supposed. In the present study, we tested this claim using a more recently developed Stroop task switching paradigm for which the internal control and attentional resources accounts made contrasting predictions. A PD group (N=30) was compared with an age-matched control group (N=34) on vocal response time (RT) for color naming and word reading in response to neutral and incongruent Stroop stimuli. Participants carried out four blocks of task repetition trials, and eight blocks of task switching trials. The results revealed that a deficit due to PD was absent for two conditions necessitating internal control, but was present in the condition which placed the highest demand on attentional resources. This selective deficit is congruent with Brown and Marsden's conclusions that depleted attentional resources, not an impairment in internal control per se, is the basis of the set shifting deficits associated with PD.

Task switching deficits associated with Parkinson's disease reflect depleted attentional resources.

Peanut allergy (PA) is a complex disease with both environmental and genetic risk factors. Previously, PA loci were identified in filaggrin (FLG) and HLA in candidate gene studies, and loci in HLA were identified in a genome-wide association study and meta-analysis.

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy.

Article	Year
Task switching deficits associated with Parkinson's disease reflect depleted attentional resources. Neuropsychologia\| PubMed ID: 12207992	2002
Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy. The Journal of allergy and clinical immunology\| PubMed ID: 29030101	2018
A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma. The Journal of allergy and clinical immunology\| PubMed ID: 29325868	2018
CIFAR humans and the microbiome: Banff meeting report. Trends in microbiology\| PubMed ID: 37482486	2023

Michael Hunter

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