study-of-experimental-organ-donation-models-for-lung-transplantation

Study of Experimental Organ Donation Models for Lung Transplantation

Experimental models are important tools for understanding the etiological phenomena involved in various pathophysiological events. In this context, ...

Universidade de São Paulo

This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.

Paolo Oliveira-Melo

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