Peter C. Dedon

Department of Biological Engineering, Massachusetts Institute of Technology

Affiliated withMassachusetts Institute of Technology Singapore-MIT Alliance for Research and Technology Antimicrobial Resistance Interdisciplinary Research Group

Research Area

Genetics

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2024

Other Publications

Article	Year
Indirect mutagenesis by oxidative DNA damage: formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9736698	1998
Absence of 2'-deoxyoxanosine and presence of abasic sites in DNA exposed to nitric oxide at controlled physiological concentrations. Chemical research in toxicology\| PubMed ID: 12971791	2003
Analysis of 3'-phosphoglycolaldehyde residues in oxidized DNA by gas chromatography/negative chemical ionization/mass spectrometry. Chemical research in toxicology\| PubMed ID: 14680370	2003
Reactive nitrogen species in the chemical biology of inflammation. Archives of biochemistry and biophysics\| PubMed ID: 14989259	2004
Reaction of 2'-deoxyribonucleosides with cis- and trans-1,4-dioxo-2-butene. Biochemical and biophysical research communications\| PubMed ID: 15381076	2004
5'-(2-phosphoryl-1,4-dioxobutane) as a product of 5'-oxidation of deoxyribose in DNA: elimination as trans-1,4-dioxo-2-butene and approaches to analysis. Chemical research in toxicology\| PubMed ID: 15540938	2004
Effects of peroxynitrite dose and dose rate on DNA damage and mutation in the supF shuttle vector. Chemical research in toxicology\| PubMed ID: 15651852	2005
Delineation of the chemical pathways underlying nitric oxide-induced homologous recombination in mammalian cells. Chemistry & biology\| PubMed ID: 15797220	2005
Chemical and biological evidence for base propenals as the major source of the endogenous M1dG adduct in cellular DNA. The Journal of biological chemistry\| PubMed ID: 15878883	2005
Differential oxidation of deoxyribose in DNA by gamma and alpha-particle radiation. Radiation research\| PubMed ID: 15913397	2005
Quantification of DNA strand breaks and abasic sites by oxime derivatization and accelerator mass spectrometry: application to gamma-radiation and peroxynitrite. Analytical biochemistry\| PubMed ID: 15964542	2005
Development of enzymatic probes of oxidative and nitrosative DNA damage caused by reactive nitrogen species. Mutation research\| PubMed ID: 16274707	2006
Biological role of glutathione in nitric oxide-induced toxicity in cell culture and animal models. Free radical biology & medicine\| PubMed ID: 16274884	2005
Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxide. Chemical research in toxicology\| PubMed ID: 16411656	2006
Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells. Chemical research in toxicology\| PubMed ID: 16544944	2006
Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation. Nature chemical biology\| PubMed ID: 16751762	2006
Formation of 1,4-dioxo-2-butene-derived adducts of 2'-deoxyadenosine and 2'-deoxycytidine in oxidized DNA. Chemical research in toxicology\| PubMed ID: 16918236	2006
Rosuvastatin: an independent analysis of risks and benefits. MedGenMed : Medscape general medicine\| PubMed ID: 16926812	2006
The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA. BMC genomics\| PubMed ID: 17163986	2006
N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17190813	2007
Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation. Carcinogenesis\| PubMed ID: 17347141	2007
AlkB influences the chloroacetaldehyde-induced mutation spectra and toxicity in the pSP189 supF shuttle vector. Chemical research in toxicology\| PubMed ID: 17658757	2007
GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomy... Chemical research in toxicology\| PubMed ID: 17944541	2007
The chemical toxicology of 2-deoxyribose oxidation in DNA. Chemical research in toxicology\| PubMed ID: 18052112	2008
Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: relationship between kinetics and distribution of alkali-labile les... The journal of physical chemistry. B\| PubMed ID: 18211057	2008
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer research\| PubMed ID: 18519673	2008
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. The Journal of clinical investigation\| PubMed ID: 18521188	2008
Surveying the damage: the challenges of developing nucleic acid biomarkers of inflammation. Molecular bioSystems\| PubMed ID: 18704228	2008
Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometr... Nature protocols\| PubMed ID: 18714297	2008
Kinetic analysis of intracellular concentrations of reactive nitrogen species. Chemical research in toxicology\| PubMed ID: 18828639	2008
DNA sequence context as a determinant of the quantity and chemistry of guanine oxidation produced by hydroxyl radicals and one-electron oxidants. The Journal of biological chemistry\| PubMed ID: 18948263	2008
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19118192	2009
An improved method for large-scale preparation of negatively and positively supercoiled plasmid DNA. BioTechniques\| PubMed ID: 19594448	2009
A general method for quantifying sequence effects on nucleobase oxidation in DNA. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20013187	2010
Recommendations for standardized description of and nomenclature concerning oxidatively damaged nucleobases in DNA. Chemical research in toxicology\| PubMed ID: 20235554	2010
Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Molecular and cellular biology\| PubMed ID: 20308323	2010
Quantification of the 2-deoxyribonolactone and nucleoside 5'-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: different... Journal of the American Chemical Society\| PubMed ID: 20377226	2010
One-electron oxidation of a pyrenyl photosensitizer covalently attached to DNA and competition between its further oxidation and DNA hole injection. Photochemistry and photobiology\| PubMed ID: 20408978	2010
Challenges in developing DNA and RNA biomarkers of inflammation. Biomarkers in medicine\| PubMed ID: 20477404	2007
A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. PLoS genetics\| PubMed ID: 21187895	2010
The biological and metabolic fates of endogenous DNA damage products. Journal of nucleic acids\| PubMed ID: 21209721	2010
DNA phosphorothioation is widespread and quantized in bacterial genomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21285367	2011
Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. International journal of cancer\| PubMed ID: 21387284	2011
Solvent exposure associated with single abasic sites alters the base sequence dependence of oxidation of guanine in DNA in GG sequence contexts. Chembiochem : a European journal of chemical biology\| PubMed ID: 21656632	2011
Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin. Molecules (Basel, Switzerland)\| PubMed ID: 21694680	2011
XRCC1 and base excision repair balance in response to nitric oxide. DNA repair\| PubMed ID: 22041025	2011
Sequence-dependent variation in the reactivity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine toward oxidation. Chemical research in toxicology\| PubMed ID: 22103813	2012
Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free radical research\| PubMed ID: 22263561	2012
Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308425	2012
2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. PLoS pathogens\| PubMed ID: 22496660	2012
Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environmental health perspectives\| PubMed ID: 22538203	2012
Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22689960	2012
A system for exposing molecules and cells to biologically relevant and accurately controlled steady-state concentrations of nitric oxide and oxygen. Nitric oxide : biology and chemistry\| PubMed ID: 22728703	2012
Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nature communications\| PubMed ID: 22760636	2012
Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. RNA biology\| PubMed ID: 22832247	2012
Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22935709	2012
In situ analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra. Journal of the American Chemical Society\| PubMed ID: 23057664	2012
Comparative analysis of four oxidized guanine lesions from reactions of DNA with peroxynitrite, singlet oxygen, and γ-radiation. Chemical research in toxicology\| PubMed ID: 23140136	2013
Quantitative analysis of histone modifications: formaldehyde is a source of pathological n(6)-formyllysine that is refractory to histone deacetylases. PLoS genetics\| PubMed ID: 23468656	2013
Increased levels of inosine in a mouse model of inflammation. Chemical research in toxicology\| PubMed ID: 23506120	2013
Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics. ACS chemical biology\| PubMed ID: 23631432	2013
An automated Fpg-based FADU method for the detection of oxidative DNA lesions and screening of antioxidants. Toxicology\| PubMed ID: 23707620	2013
Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23754421	2013
DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. PLoS pathogens\| PubMed ID: 23853579	2013
A multidimensional platform for the purification of non-coding RNA species. Nucleic acids research\| PubMed ID: 23907385	2013
Chemistry meets biology in colitis-associated carcinogenesis. Free radical research\| PubMed ID: 23926919	2013
Induction of functional human macrophages from bone marrow promonocytes by M-CSF in humanized mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23935193	2013
Dosimetry of N⁶-formyllysine adducts following [¹³C²H₂]-formaldehyde exposures in rats. Chemical research in toxicology\| PubMed ID: 24087891	2013
Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. RNA (New York, N.Y.)\| PubMed ID: 24344322	2014
A system of RNA modifications and biased codon use controls cellular stress response at the level of translation. Chemical research in toxicology\| PubMed ID: 24422464	2014
28S rRNA is inducibly pseudouridylated by the mTOR pathway translational control in CHO cell cultures. Journal of biotechnology\| PubMed ID: 24480570	2014
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Nature protocols\| PubMed ID: 24625781	2014
Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature communications\| PubMed ID: 24899568	2014
Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella. Molecular microbiology\| PubMed ID: 25040300	2014
tRNA modifications regulate translation during cellular stress. FEBS letters\| PubMed ID: 25304425	2014
Diverse cell stresses induce unique patterns of tRNA up- and down-regulation: tRNA-seq for quantifying changes in tRNA copy number. Nucleic acids research\| PubMed ID: 25348403	2014
Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectru... Nucleic acids research\| PubMed ID: 25539917	2015
Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes. Chemical research in toxicology\| PubMed ID: 25772370	2015
Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responses. RNA biology\| PubMed ID: 25892531	2015
Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage. PloS one\| PubMed ID: 26147969	2015
A Platform for Discovery and Quantification of Modified Ribonucleosides in RNA: Application to Stress-Induced Reprogramming of tRNA Modifications. Methods in enzymology\| PubMed ID: 26253965	2015
Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26283391	2015
An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis. RNA (New York, N.Y.)\| PubMed ID: 26516084	2015
Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation. PLoS genetics\| PubMed ID: 26670883	2015
Novel genomic island modifies DNA with 7-deazaguanine derivatives. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26929322	2016
Immunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea). The FEBS journal\| PubMed ID: 27007913	2016
Gene- and genome-based analysis of significant codon patterns in yeast, rat and mice genomes with the CUT Codon UTilization tool. Methods (San Diego, Calif.)\| PubMed ID: 27245397	2016
The role of sequence context, nucleotide pool balance and stress in 2'-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA. Nucleic acids research\| PubMed ID: 27365049	2016
Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa. Nucleic acids research\| PubMed ID: 27683218	2016
tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence. Nature communications\| PubMed ID: 27834374	2016
tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy. European journal of human genetics : EJHG\| PubMed ID: 28272532	2017
Production of Superoxide in Bacteria Is Stress- and Cell State-Dependent: A Gating-Optimized Flow Cytometry Method that Minimizes ROS Measurement Artifacts with Fluorescent Dyes. Frontiers in microbiology\| PubMed ID: 28377755	2017
Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28400512	2017
Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability. Nature chemical biology\| PubMed ID: 28604692	2017
Three distinct 3-methylcytidine (mC) methyltransferases modify tRNA and mRNA in mice and humans. The Journal of biological chemistry\| PubMed ID: 28655767	2017
The mA pathway facilitates sex determination in Drosophila. Nature communications\| PubMed ID: 28675155	2017
N-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats. Chemical research in toxicology\| PubMed ID: 28692800	2017
The tA modification acts as a positive determinant for the anticodon nuclease PrrC, and is distinctively nonessential in Streptococcus mutans. RNA biology\| PubMed ID: 28726545	2018
Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nature genetics\| PubMed ID: 28805828	2017
Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nature communications\| PubMed ID: 29215013	2017
Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29610140	2018
Phosphorylation of human TRM9L integrates multiple stress-signaling pathways for tumor growth suppression. Science advances\| PubMed ID: 30009260	2018
Identification of the minimal bacterial 2'-deoxy-7-amido-7-deazaguanine synthesis machinery. Molecular microbiology\| PubMed ID: 30159947	2018
Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake. Journal of agricultural and food chemistry\| PubMed ID: 30286603	2018
tRNA epitranscriptomics and biased codon are linked to proteome expression in . Molecular systems biology\| PubMed ID: 30287681	2018
DNA phosphorothioate modification-a new multi-functional epigenetic system in bacteria. FEMS microbiology reviews\| PubMed ID: 30289455	2019
Backbone resonance assignment for the N-terminal region of bacterial tRNA-(NG37) methyltransferase. Biomolecular NMR assignments\| PubMed ID: 30298375	2019
A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth. iScience\| PubMed ID: 30466063	2018
Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses. Genome biology\| PubMed ID: 30587213	2018
The Versatile Roles of the tRNA Epitranscriptome during Cellular Responses to Toxic Exposures and Environmental Stress. Toxics\| PubMed ID: 30934574	2019
Backbone resonance assignment for the full length tRNA-(NG37) methyltransferase of Pseudomonas aeruginosa. Biomolecular NMR assignments\| PubMed ID: 31175551	2019
The road less traveled: A new phosphorothioate antiviral defense mechanism discovered in Archaea. Synthetic and systems biotechnology\| PubMed ID: 31312729	2019
Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis. Journal of molecular biology\| PubMed ID: 31381898	2019
Transcriptome-wide dynamics of extensive mA mRNA methylation during Plasmodium falciparum blood-stage development. Nature microbiology\| PubMed ID: 31384004	2019
Crystal structure and catalytic mechanism of the essential mG37 tRNA methyltransferase TrmD from . RNA (New York, N.Y.)\| PubMed ID: 31399541	2019
Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism. Journal of medicinal chemistry\| PubMed ID: 31442049	2019
Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31481610	2019
Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA. Nucleic acids research\| PubMed ID: 31504804	2019
Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites. Nucleic acids research\| PubMed ID: 31777939	2020
7-Deazaguanine modifications protect phage DNA from host restriction systems. Nature communications\| PubMed ID: 31784519	2019
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. Nature communications\| PubMed ID: 31941883	2020
Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast. Biomolecules\| PubMed ID: 32085421	2020
SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities. Nature microbiology\| PubMed ID: 32251370	2020
The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene. Epigenetics\| PubMed ID: 32303148	2020
Nick-seq for single-nucleotide resolution genomic maps of DNA modifications and damage. Nucleic acids research\| PubMed ID: 32484547	2020
Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32518115	2020
DNA Phosphorothioate Modifications Are Widely Distributed in the Human Microbiome. Biomolecules\| PubMed ID: 32806589	2020
Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite. Molecular systems biology\| PubMed ID: 32816370	2020
Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism. Biochemical and biophysical research communications\| PubMed ID: 32878705	2020
Crystal structure of the periplasmic sensor domain of histidine kinase VbrK suggests indirect sensing of β-lactam antibiotics. Journal of structural biology\| PubMed ID: 32890780	2020
tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast. RNA biology\| PubMed ID: 32893724	2021
Detection of preQ0 deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs. Nucleic acids research\| PubMed ID: 32941607	2020
Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens. Cell systems\| PubMed ID: 32970993	2020
Development of Methods Derived from Iodine-Induced Specific Cleavage for Identification and Quantitation of DNA Phosphorothioate Modifications. Biomolecules\| PubMed ID: 33126637	2020
Queuine Is a Nutritional Regulator of Entamoeba histolytica Response to Oxidative Stress and a Virulence Attenuator. mBio\| PubMed ID: 33688012	2021
Quantitative mapping of the cellular small RNA landscape with AQRNA-seq. Nature biotechnology\| PubMed ID: 33859402	2021
Functional Characterization of the mA-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite. mBio\| PubMed ID: 33906926	2021
Detecting the epitranscriptome. Wiley interdisciplinary reviews. RNA\| PubMed ID: 33987958	2021
Bacteriophage vB_PagS_MED16-A Siphovirus Containing a 2'-Deoxy-7-amido-7-deazaguanosine-Modified DNA. International journal of molecular sciences\| PubMed ID: 34298953	2021
Strategies to Avoid Artifacts in Mass Spectrometry-Based Epitranscriptome Analyses. Angewandte Chemie (International ed. in English)\| PubMed ID: 34339593	2021
Crystal structure and functional analysis of mycobacterial erythromycin resistance methyltransferase Erm38 reveals its RNA-binding site. The Journal of biological chemistry\| PubMed ID: 35007529	2022
Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences. Frontiers in microbiology\| PubMed ID: 35531280	2022
Queuine Salvaging in the Human Parasite . Cells\| PubMed ID: 36010587	2022
The absence of the queuosine tRNA modification leads to pleiotropic phenotypes revealing perturbations of metal and oxidative stress homeostasis in Escherichia coli K12. Metallomics : integrated biometal science\| PubMed ID: 36066904	2022
Arsenite toxicity is regulated by queuine availability and oxidation-induced reprogramming of the human tRNA epitranscriptome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36095201	2022
Dysfunctional tRNA reprogramming and codon-biased translation in cancer. Trends in molecular medicine\| PubMed ID: 36241532	2022
DNA Modifications Enabling Proximity Biotinylation. Bioconjugate chemistry\| PubMed ID: 36888923	2023
Accumulation of mA exhibits stronger correlation with MAPT than β-amyloid pathology in an APP /MAPT mouse model of Alzheimer's disease. bioRxiv : the preprint server for biology\| PubMed ID: 37034774	2023
Rifaximin potentiates clarithromycin against and in zebrafish. JAC-antimicrobial resistance\| PubMed ID: 37168836	2023
Accumulation of mA exhibits stronger correlation with MAPT than β-amyloid pathology in an APP /MAPT mouse model of Alzheimer's disease. Research square\| PubMed ID: 37292629	2023
An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis. Nature communications\| PubMed ID: 37433804	2023
A systems-level mass spectrometry-based technique for accurate and sensitive quantification of the RNA cap epitranscriptome. Nature protocols\| PubMed ID: 37567932	2023
Four additional natural 7-deazaguanine derivatives in phages and how to make them. Nucleic acids research\| PubMed ID: 37572349	2023
Cohesin contributes to transcriptional repression of stage-specific genes in the human malaria parasite. EMBO reports\| PubMed ID: 37592911	2023
Nanopore-based direct sequencing of RNA transcripts with 10 different modified nucleotides reveals gaps in existing technology. G3 (Bethesda, Md.)\| PubMed ID: 37655917	2023
Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans. Nucleic acids research\| PubMed ID: 37843128	2023
Dengue virus exploits the host tRNA epitranscriptome to promote viral replication. bioRxiv : the preprint server for biology\| PubMed ID: 37986976	2023
Molecular Coping Mechanisms: Reprogramming tRNAs To Regulate Codon-Biased Translation of Stress Response Proteins. Accounts of chemical research\| PubMed ID: 37992267	2023
The Greatwall-Endosulfine-PP2A/B55 pathway controls entry into quiescence by promoting translation of Elongator-tuneable transcripts. Research square\| PubMed ID: 38105947	2023
Queuosine Salvage in Houston 1: A Unique Evolutionary Path. bioRxiv : the preprint server for biology\| PubMed ID: 38106016	2023