Rosalie C Sears

Brenden-Colson Canter for Pancreatic Care, Oregon Health & Science University

Affiliated withOregon Health & Science University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
The life cycle of C-myc: from synthesis to degradation. Cell cycle (Georgetown, Tex.)\| PubMed ID: 15467447	2004
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc. The EMBO journal\| PubMed ID: 19131971	2009
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental cell\| PubMed ID: 20708588	2010
Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3Î² and CDK1. Cancer research\| PubMed ID: 21646472	2011
Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Molecular and cellular biology\| PubMed ID: 21807902	2011
PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells. Oncogene\| PubMed ID: 21822300	2012
Studying c-Myc serine 62 phosphorylation in leukemia cells: concern over antibody cross-reactivity. Blood\| PubMed ID: 22653959	2012
A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23150551	2012
N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23248303	2013
Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis. Molecular and cellular biology\| PubMed ID: 23716601	2013
Diminished WNT -> β-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors. Genes & development\| PubMed ID: 24589553	2014
MYC degradation. Cold Spring Harbor perspectives in medicine\| PubMed ID: 24591536	2014
Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer. Molecular cancer research : MCR\| PubMed ID: 24667985	2014
Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24927563	2014
The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25775507	2015
Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. Journal of medicinal chemistry\| PubMed ID: 26023867	2015
Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation. Cell reports\| PubMed ID: 26235622	2015
Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity. Structure (London, England : 1993)\| PubMed ID: 26655473	2015
Deubiquitinating c-Myc: USP36 steps up in the nucleolus. Cell cycle (Georgetown, Tex.)\| PubMed ID: 26697836	2015
Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC. American journal of physiology. Cell physiology\| PubMed ID: 27903583	2017
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. The Journal of clinical investigation\| PubMed ID: 28504649	2017
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature communications\| PubMed ID: 29170413	2017
The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model. PloS one\| PubMed ID: 29190822	2017
The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase. Biochemical and biophysical research communications\| PubMed ID: 29274341	2018
MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers. Matters\| PubMed ID: 29527532	2016
Serum Biomarker Signature-Based Liquid Biopsy for Diagnosis of Early-Stage Pancreatic Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 30106639	2018
Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups. Cancer cell\| PubMed ID: 30205044	2018
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer. Nature communications\| PubMed ID: 30232459	2018
SUMO protease SENP1 deSUMOylates and stabilizes c-Myc. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30305424	2018
Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals. Genes & development\| PubMed ID: 30366908	2018
Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma. Cancer research\| PubMed ID: 30389701	2019
Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting. Cell reports\| PubMed ID: 30650355	2019
A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression. Cancer discovery\| PubMed ID: 30837243	2019
Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer. PLoS computational biology\| PubMed ID: 30856168	2019
The use of protein phosphatase 2A activators in combination therapies for pancreas cancer. Oncotarget\| PubMed ID: 31007842	2019
Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming. Cancer discovery\| PubMed ID: 31266770	2019
Mission Possible: Advances in MYC Therapeutic Targeting in Cancer. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy\| PubMed ID: 31392631	2019
Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity. The Journal of clinical investigation\| PubMed ID: 31763993	2020
Writing and erasing MYC ubiquitination and SUMOylation. Genes & diseases\| PubMed ID: 31832515	2019
Deconstructing Pancreatic Adenocarcinoma by Targeting the Conductor, MYC. Cancer discovery\| PubMed ID: 32238397	2020
PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals. Frontiers in cell and developmental biology\| PubMed ID: 32300594	2020
Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer. The Journal of experimental medicine\| PubMed ID: 32434218	2020
Select Stabilization of a Tumor-Suppressive PP2A Heterotrimer. Trends in pharmacological sciences\| PubMed ID: 32624198	2020
Hypoxia: Friend or Foe for drug delivery in Pancreatic Cancer. Cancer letters\| PubMed ID: 32822815	2020
Altering MYC phosphorylation in the epidermis increases the stem cell population and contributes to the development, progression, and metastasis of squamous cell carcinoma. Oncogenesis\| PubMed ID: 32895364	2020
Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome. Cancer discovery\| PubMed ID: 33727309	2021
The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis. EMBO reports\| PubMed ID: 33852194	2021
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. Nature\| PubMed ID: 33854232	2021
Loss of Ambra1 promotes melanoma growth and invasion. Nature communications\| PubMed ID: 33953176	2021
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nature chemical biology\| PubMed ID: 33972797	2021
Detection of Post-translational Modifications on MYC. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34019287	2021
Tumor-Infiltrating Leukocyte Phenotypes Distinguish Outcomes in Related Patients With Pancreatic Adenocarcinoma. JCO precision oncology\| PubMed ID: 34036232	2021
Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy. Frontiers in oncology\| PubMed ID: 34178666	2021
Analysis of Primary Tumor Specimens for Evaluation of Cancer Therapeutics. Annual review of cancer biology\| PubMed ID: 34222745	2021
High-content single-cell combinatorial indexing. Nature biotechnology\| PubMed ID: 34226710	2021
Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies. Cancer & metabolism\| PubMed ID: 34399819	2021
T-cell Dysfunction upon Expression of MYC with Altered Phosphorylation at Threonine 58 and Serine 62. Molecular cancer research : MCR\| PubMed ID: 35380701	2022
HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms. Cancers\| PubMed ID: 35406624	2022
Microfluidics Formulated Liposomes of Hypoxia Activated Prodrug for Treatment of Pancreatic Cancer. Pharmaceutics\| PubMed ID: 35456547	2022
The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma. Molecular and cellular biology\| PubMed ID: 35703534	2022
Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer research\| PubMed ID: 35819261	2022
A path to translation: How 3D patient tumor avatars enable next generation precision oncology. Cancer cell\| PubMed ID: 36270276	2022
Robust biomarker discovery through multiplatform multiplex image analysis of breast cancer clinical cohorts. bioRxiv : the preprint server for biology\| PubMed ID: 36778343	2023
The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing. Nucleic acids research\| PubMed ID: 36912080	2023
Deletion of the mRNA stability factor (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity. NAR cancer\| PubMed ID: 37089813	2023
MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer. Nature communications\| PubMed ID: 37704631	2023
Unraveling MYC's Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance. Pathophysiology : the official journal of the International Society for Pathophysiology\| PubMed ID: 37755397	2023
Accessible high-throughput single-cell whole-genome sequencing with paired chromatin accessibility. Cell reports methods\| PubMed ID: 37918402	2023
Micelle-Formulated Juglone Effectively Targets Pancreatic Cancer and Remodels the Tumor Microenvironment. Pharmaceutics\| PubMed ID: 38139993	2023