Viacheslav O. Nikolaev

Emmy Noether Group of the DFG, Georg August University Medical Center, Göttingen, Germany

Affiliated withGeorg August University Medical Center, Göttingen, Germany DZHK (German Center for Cardiovascular Research)University Medical Center Hamburg-Eppendorf

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 29	2012
Publication title Cited by 6	2018

Other Publications

Article	Year
Novel single chain cAMP sensors for receptor-induced signal propagation. The Journal of biological chemistry\| PubMed ID: 15231839	2004
Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis. The Journal of biological chemistry\| PubMed ID: 15557342	2005
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. The Journal of biological chemistry\| PubMed ID: 15987680	2005
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16236727	2005
Fluorescent sensors for rapid monitoring of intracellular cGMP. Nature methods\| PubMed ID: 16369548	2006
Monitoring of cAMP synthesis and degradation in living cells. Physiology (Bethesda, Md.)\| PubMed ID: 16565474	2006
Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer. The Journal of biological chemistry\| PubMed ID: 16787921	2006
Gs activation is time-limiting in initiating receptor-mediated signaling. The Journal of biological chemistry\| PubMed ID: 16963443	2006
Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells. Science's STKE : signal transduction knowledge environment\| PubMed ID: 16985238	2006
Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circulation research\| PubMed ID: 17038640	2006
Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. The Journal of clinical investigation\| PubMed ID: 17200720	2007
cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes. The Journal of physiology\| PubMed ID: 17289786	2007
Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. The Journal of biological chemistry\| PubMed ID: 17616524	2007
A novel fluorescence method for the rapid detection of functional beta1-adrenergic receptor autoantibodies in heart failure. Journal of the American College of Cardiology\| PubMed ID: 17662395	2007
Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells. Advances in protein chemistry\| PubMed ID: 17854658	2007
Monitoring receptor signaling by intramolecular FRET. Current opinion in pharmacology\| PubMed ID: 17919975	2007
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nature chemical biology\| PubMed ID: 18193048	2008
Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends in pharmacological sciences\| PubMed ID: 18262662	2008
Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases. Circulation research\| PubMed ID: 18369156	2008
Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron\| PubMed ID: 18439407	2008
Real-time monitoring of phosphodiesterase inhibition in intact cells. Cellular signalling\| PubMed ID: 18467075	2008
Cytoplasmic cAMP concentrations in intact cardiac myocytes. American journal of physiology. Cell physiology\| PubMed ID: 18550706	2008
Immunoadsorption in a 40 year old man with dilated cardiomyopathy and underlying active myocarditis. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 18633566	2008
Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. The Journal of clinical investigation\| PubMed ID: 18636120	2008
Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling. The Journal of biological chemistry\| PubMed ID: 18713751	2008
Novel techniques for real-time monitoring of cGMP in living cells. Handbook of experimental pharmacology\| PubMed ID: 19089332	2009
GPCR and G proteins: drug efficacy and activation in live cells. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 19196832	2009
Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PloS one\| PubMed ID: 19352508	2009
Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development (Cambridge, England)\| PubMed ID: 19429786	2009
A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 19680684	2009
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS biology\| PubMed ID: 19688034	2009
Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells. American journal of physiology. Cell physiology\| PubMed ID: 19889965	2010
Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells. Journal of cell science\| PubMed ID: 20016070	2010
A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation. The Journal of biological chemistry\| PubMed ID: 20083608	2010
Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science (New York, N.Y.)\| PubMed ID: 20185685	2010
Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes. PloS one\| PubMed ID: 20300620	2010
Signaling by internalized G-protein-coupled receptors. Trends in pharmacological sciences\| PubMed ID: 20303186	2010
Imaging of persistent cAMP signaling by internalized G protein-coupled receptors. Journal of molecular endocrinology\| PubMed ID: 20378719	2010
Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20427672	2010
Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary. Endocrinology\| PubMed ID: 20610560	2010
Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH. Reproduction (Cambridge, England)\| PubMed ID: 20826538	2010
Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells. Journal of the Royal Society, Interface / the Royal Society\| PubMed ID: 21325316	2011
Distinct pharmacological properties of morphine metabolites at G(i)-protein and Î²-arrestin signaling pathways activated by the human Î¼-opioid receptor. Biochemical pharmacology\| PubMed ID: 21396918	2011
Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest. Reproduction (Cambridge, England)\| PubMed ID: 21411693	2011
FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells. Nature protocols\| PubMed ID: 21412271	2011
A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart. Hepatology (Baltimore, Md.)\| PubMed ID: 21809354	2011
Atrial natriuretic peptide enhances microvascular albumin permeability by the caveolae-mediated transcellular pathway. Cardiovascular research\| PubMed ID: 22025581	2012
A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22027011	2011
Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors. Clinical chemistry and laboratory medicine : CCLM / FESCC\| PubMed ID: 22149738	2011
Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. The Journal of clinical investigation\| PubMed ID: 22354168	2012
Plasticity of surface structures and Î²(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circulation. Heart failure\| PubMed ID: 22456061	2012
DT-2 is a specific PKG I inhibitor only in vitro, but not in a living cells. British journal of pharmacology\| PubMed ID: 22612416	2012
High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a Î²2-Adrenergic Receptor/Gi-Dependent Manner: A New Model of Takotsubo Cardiomyopathy. Circulation\| PubMed ID: 22732314	2012