Paul Brennan

Systems Immunity Research Institute, Cardiff University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2024

Other Publications

Article	Year
Mechanism of action of a novel latent membrane protein-1 dominant negative. The Journal of biological chemistry\| PubMed ID: 11031256	2001
CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells. The Journal of biological chemistry\| PubMed ID: 15364920	2004
LY294002 and rapamycin co-operate to inhibit T-cell proliferation. British journal of pharmacology\| PubMed ID: 15778701	2005
Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A mutant. Arthritis and rheumatism\| PubMed ID: 15818692	2005
Susceptibility of B lymphocytes to adenovirus type 5 infection is dependent upon both coxsackie-adenovirus receptor and alphavbeta5 integrin expression. The Journal of general virology\| PubMed ID: 15914844	2005
Mutation of the extracellular domain of tumour necrosis factor receptor 1 causes reduced NF-kappaB activation due to decreased surface expression. FEBS letters\| PubMed ID: 16162344	2005
Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16493049	2006
Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A. Journal of virology\| PubMed ID: 16943287	2006
Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes. The Journal of general virology\| PubMed ID: 17554018	2007
The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood\| PubMed ID: 18227347	2008
Proliferation and interleukin 5 production by CD8hi CD57+ T cells. European journal of immunology\| PubMed ID: 18383036	2008
Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers. Blood\| PubMed ID: 18599795	2008
Targeting transcription factors for therapeutic benefit. Molecular bioSystems\| PubMed ID: 18704229	2008
The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19088025	2008
Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 19124804	2009
Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 19409429	2009
STAT1 contributes to the maintenance of the latency III viral programme observed in Epstein-Barr virus-transformed B cells and their recognition by CD8+ T cells. The Journal of general virology\| PubMed ID: 19439556	2009
Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19542461	2009
NF-kappaB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia. Future oncology (London, England)\| PubMed ID: 19792971	2009
Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation. Nucleic acids research\| PubMed ID: 20100803	2010
Bicarbonate-dependent serine/threonine protein dephosphorylation in capacitating boar spermatozoa. Journal of andrology\| PubMed ID: 20203338	2010
Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38. Haematologica\| PubMed ID: 20207849	2010
Proteomics analysis of bladder cancer exosomes. Molecular & cellular proteomics : MCP\| PubMed ID: 20224111	2010
Co-operative membrane disruption between cell-penetrating peptide and cargo: implications for the therapeutic use of the Bcl-2 converter peptide D-NuBCP-9-r8. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21934653	2011
Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals\| PubMed ID: 21966894	2011
Defining the prognosis of early stage chronic lymphocytic leukaemia patients. British journal of haematology\| PubMed ID: 22171799	2012
Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. The Journal of biological chemistry\| PubMed ID: 22311974	2012
Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells. Haematologica\| PubMed ID: 23812940	2013
A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine. Oncotarget\| PubMed ID: 24495868	2014
Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia. Blood\| PubMed ID: 24637360	2014
Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia. Journal of proteome research\| PubMed ID: 24983324	2014
External ventricular drainage: Is it time to look at national practice? British journal of neurosurgery\| PubMed ID: 25188651	2015
Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics. Clinical applications\| PubMed ID: 26238753	2009
Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array. Journal of extracellular vesicles\| PubMed ID: 27363484	2016
Key Molecular Drivers of Chronic Lymphocytic Leukemia. Clinical lymphoma, myeloma & leukemia\| PubMed ID: 27601002	2016
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Nature communications\| PubMed ID: 28165464	2017
drawProteins: a Bioconductor/R package for reproducible and programmatic generation of protein schematics. F1000Research\| PubMed ID: 30210791	2018
Effective Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors. Molecular therapy. Methods & clinical development\| PubMed ID: 31720306
Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival. Life science alliance\| PubMed ID: 34645618	2021
100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report. The New England journal of medicine\| PubMed ID: 34758253	2021
Essential role of staff development in addressing structural racism. Lancet (London, England)\| PubMed ID: 37330737	2023