Philip R. Taylor

Systems Immunity Research Institute, Cardiff University

Affiliated withCardiff University UK Dementia Research Institute

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2024

Other Publications

Article	Year
Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice. European journal of immunology\| PubMed ID: 17694571	2007
Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. European journal of immunology\| PubMed ID: 18350551	2008
Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18641356	2008
The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18714028	2008
12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18941242	2008
The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection. Infection and immunity\| PubMed ID: 18981244	2009
CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19299712	2009
Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1. American journal of respiratory cell and molecular biology\| PubMed ID: 19502385	2010
Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. The Journal of biological chemistry\| PubMed ID: 19531470	2009
Complement C3 plays an essential role in the control of opportunistic fungal infections. Infection and immunity\| PubMed ID: 19581397	2009
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. The Journal of experimental medicine\| PubMed ID: 19703985	2009
The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B. Journal of leukocyte biology\| PubMed ID: 20400676	2010
Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans. The Journal of biological chemistry\| PubMed ID: 20643646	2010
Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood\| PubMed ID: 20921338	2010
Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood\| PubMed ID: 21177434	2011
Fungal recognition enhances mannose receptor shedding through dectin-1 engagement. The Journal of biological chemistry\| PubMed ID: 21205820	2011
Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells. European journal of immunology\| PubMed ID: 21268006	2011
Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax\| PubMed ID: 21310755	2011
In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21368104	2011
Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin. Cell host & microbe\| PubMed ID: 21575914	2011
A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European journal of immunology\| PubMed ID: 21710478	2011
Macrophage heterogeneity and acute inflammation. European journal of immunology\| PubMed ID: 21952806	2011
Development of myeloproliferative disease in 12/15-lipoxygenase deficiency. Blood\| PubMed ID: 22730527	2012
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcÎ³RIIB and dectin-1. Nature medicine\| PubMed ID: 22922409	2012
Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. PloS one\| PubMed ID: 23049859	2012
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. PloS one\| PubMed ID: 23451151	2013
LAB/NTAL Facilitates Fungal/PAMP-induced IL-12 and IFN-Î³ Production by Repressing Î²-Catenin Activation in Dendritic Cells. PLoS pathogens\| PubMed ID: 23675302	2013
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature communications\| PubMed ID: 23695680	2013
Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European journal of immunology\| PubMed ID: 23857287	2013
Tissue-resident macrophages. Nature immunology\| PubMed ID: 24048120	2013
Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity\| PubMed ID: 24412616	2014
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages. Nature communications\| PubMed ID: 24423728	2014
miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. The American journal of pathology\| PubMed ID: 24508230	2014
Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell host & microbe\| PubMed ID: 24721575	2014
The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science (New York, N.Y.)\| PubMed ID: 24762537	2014
Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis research & therapy\| PubMed ID: 25175678	2014
Understanding local macrophage phenotypes in disease: shape-shifting macrophages. Nature medicine\| PubMed ID: 25654602	2015
CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS pathogens\| PubMed ID: 25654642	2015
IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27259855	2016
IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European journal of immunology\| PubMed ID: 27378515	2016
Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease. The American journal of pathology\| PubMed ID: 27664471	2016
Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes. Kidney international\| PubMed ID: 28065517	2017
Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels . Wellcome open research\| PubMed ID: 28239665	2017
miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. The American journal of pathology\| PubMed ID: 28495592	2017
Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular immunology\| PubMed ID: 28942944	2017
Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science signaling\| PubMed ID: 29184033	2017
Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels. Nature communications\| PubMed ID: 29234000	2017
Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 29401615	2018
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30355783	2018
Activation of naïve CD4 T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 T cells. Nature immunology\| PubMed ID: 30890796	2019
Development and characterization of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species. Immunology\| PubMed ID: 31120547	2019
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS pathogens\| PubMed ID: 31242262	2019
Dependence on Dectin-1 Varies With Multiple Species. Frontiers in microbiology\| PubMed ID: 31447813	2019
Effective Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors. Molecular therapy. Methods & clinical development\| PubMed ID: 31720306
Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway. The EMBO journal\| PubMed ID: 32484988
Macrophage reprogramming for therapy. Immunology\| PubMed ID: 33368269
Dependence on Mincle and Dectin-2 Varies With Multiple Species During Systemic Infection. Frontiers in microbiology\| PubMed ID: 33717025	2021
A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis. The Journal of infectious diseases\| PubMed ID: 33733279	2021
Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 34155061	2021
PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522. The EMBO journal\| PubMed ID: 34254352	2021
Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease. Scientific reports\| PubMed ID: 34294785	2021
A Novel Strategy to Identify Haematology Patients at High Risk of Developing Aspergillosis. Frontiers in immunology\| PubMed ID: 34975870	2021
Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature communications\| PubMed ID: 35013270	2022
3R Blackboard: A platform for animal and organ sharing. Laboratory animals\| PubMed ID: 35023399
Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models. Acta neuropathologica communications\| PubMed ID: 35794654	2022
Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 37272871	2023

Article	Year
Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice. European journal of immunology\| PubMed ID: 17694571	2007
Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. European journal of immunology\| PubMed ID: 18350551	2008
Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18641356	2008
The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18714028	2008
12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18941242	2008
The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection. Infection and immunity\| PubMed ID: 18981244	2009
CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19299712	2009
Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1. American journal of respiratory cell and molecular biology\| PubMed ID: 19502385	2010
Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. The Journal of biological chemistry\| PubMed ID: 19531470	2009
Complement C3 plays an essential role in the control of opportunistic fungal infections. Infection and immunity\| PubMed ID: 19581397	2009
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. The Journal of experimental medicine\| PubMed ID: 19703985	2009
The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B. Journal of leukocyte biology\| PubMed ID: 20400676	2010
Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans. The Journal of biological chemistry\| PubMed ID: 20643646	2010
Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood\| PubMed ID: 20921338	2010
Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood\| PubMed ID: 21177434	2011
Fungal recognition enhances mannose receptor shedding through dectin-1 engagement. The Journal of biological chemistry\| PubMed ID: 21205820	2011
Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells. European journal of immunology\| PubMed ID: 21268006	2011
Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax\| PubMed ID: 21310755	2011
In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21368104	2011
Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin. Cell host & microbe\| PubMed ID: 21575914	2011
A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European journal of immunology\| PubMed ID: 21710478	2011
Macrophage heterogeneity and acute inflammation. European journal of immunology\| PubMed ID: 21952806	2011
Development of myeloproliferative disease in 12/15-lipoxygenase deficiency. Blood\| PubMed ID: 22730527	2012
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcÎ³RIIB and dectin-1. Nature medicine\| PubMed ID: 22922409	2012
Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. PloS one\| PubMed ID: 23049859	2012
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. PloS one\| PubMed ID: 23451151	2013
LAB/NTAL Facilitates Fungal/PAMP-induced IL-12 and IFN-Î³ Production by Repressing Î²-Catenin Activation in Dendritic Cells. PLoS pathogens\| PubMed ID: 23675302	2013
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature communications\| PubMed ID: 23695680	2013
Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European journal of immunology\| PubMed ID: 23857287	2013
Tissue-resident macrophages. Nature immunology\| PubMed ID: 24048120	2013
Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity\| PubMed ID: 24412616	2014
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages. Nature communications\| PubMed ID: 24423728	2014
miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. The American journal of pathology\| PubMed ID: 24508230	2014
Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell host & microbe\| PubMed ID: 24721575	2014
The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science (New York, N.Y.)\| PubMed ID: 24762537	2014
Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis research & therapy\| PubMed ID: 25175678	2014
Understanding local macrophage phenotypes in disease: shape-shifting macrophages. Nature medicine\| PubMed ID: 25654602	2015
CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS pathogens\| PubMed ID: 25654642	2015
IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27259855	2016
IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European journal of immunology\| PubMed ID: 27378515	2016
Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease. The American journal of pathology\| PubMed ID: 27664471	2016
Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes. Kidney international\| PubMed ID: 28065517	2017
Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels . Wellcome open research\| PubMed ID: 28239665	2017
miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. The American journal of pathology\| PubMed ID: 28495592	2017
Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular immunology\| PubMed ID: 28942944	2017
Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science signaling\| PubMed ID: 29184033	2017
Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels. Nature communications\| PubMed ID: 29234000	2017
Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 29401615	2018
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30355783	2018
Activation of naïve CD4 T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 T cells. Nature immunology\| PubMed ID: 30890796	2019
Development and characterization of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species. Immunology\| PubMed ID: 31120547	2019
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS pathogens\| PubMed ID: 31242262	2019
Dependence on Dectin-1 Varies With Multiple Species. Frontiers in microbiology\| PubMed ID: 31447813	2019
Effective Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors. Molecular therapy. Methods & clinical development\| PubMed ID: 31720306
Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway. The EMBO journal\| PubMed ID: 32484988
Macrophage reprogramming for therapy. Immunology\| PubMed ID: 33368269
Dependence on Mincle and Dectin-2 Varies With Multiple Species During Systemic Infection. Frontiers in microbiology\| PubMed ID: 33717025	2021
A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis. The Journal of infectious diseases\| PubMed ID: 33733279	2021
Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 34155061	2021
PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522. The EMBO journal\| PubMed ID: 34254352	2021
Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease. Scientific reports\| PubMed ID: 34294785	2021
A Novel Strategy to Identify Haematology Patients at High Risk of Developing Aspergillosis. Frontiers in immunology\| PubMed ID: 34975870	2021
Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature communications\| PubMed ID: 35013270	2022
3R Blackboard: A platform for animal and organ sharing. Laboratory animals\| PubMed ID: 35023399
Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models. Acta neuropathologica communications\| PubMed ID: 35794654	2022
Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 37272871	2023