targeted-muscle-reinnervation-surgical-protocol-for-randomized

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Over the past decade, the field of prosthetics has witnessed significant progress, particularly in the development of surgical techniques to enhance the ...

regenerative-peripheral-nerve-interface-surgical-protocol-for

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Surgical procedures, including nerve reconstruction and end-organ muscle reinnervation, have become more prominent in the prosthetic field over the past ...

Center for Bionics and Pain Research

IRCCS Istituto Ortopedico Rizzoli

Painful conditions such as residual limb pain (RLP) and phantom limb pain (PLP) can manifest after amputation. The mechanisms underlying such postamputation pains are diverse and should be addressed accordingly. Different surgical treatment methods have shown potential for alleviating RLP due to neuroma formation - commonly known as neuroma pain - and to a lesser degree PLP. Two reconstructive surgical interventions, namely targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI), are gaining popularity in postamputation pain treatment with promising results. However, these two methods have not been directly compared in a randomised controlled trial (RCT). Here, we present a study protocol for an international, double-blind, RCT to assess the effectiveness of TMR, RPNI, and a non-reconstructive procedure called neuroma transposition (active control) in alleviating RLP, neuroma pain, and PLP.

Surgical treatments for postamputation pain: study protocol for an international, double-blind, randomised controlled trial.

Correction: Surgical treatments for postamputation pain: study protocol for an international, double-blind, randomised controlled trial.

Despite modern advancements in the treatment of late stages of wrist joint degeneration, few reliable options exist for patients requiring motion-preserving reconstruction of their radiocarpal and midcarpal joints. Vascularized composite allotransplantation (VCA) could be considered an option for wrist reconstruction in the future. The goal of this study was to describe the relevant anatomy and design a potential surgical technique for wrist VCA.

ArticleTotal : 2	Year
Publication title Cited by 5	2024
Publication title Cited by 5	2024

Article	Year
Surgical treatments for postamputation pain: study protocol for an international, double-blind, randomised controlled trial. Trials\| PubMed ID: 37131180	2023
Correction: Surgical treatments for postamputation pain: study protocol for an international, double-blind, randomised controlled trial. Trials\| PubMed ID: 37814331	2023
Surgical Feasibility Study on Cadaver for Vascularized Wrist Joint Transplantation. The Journal of hand surgery\| PubMed ID: 38069954	2024

Francesca Alice Pedrini

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