retroperitoneal-laparoscopic-debridement-drainage-for-pancreatic

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess

In patients with severe necrotizing pancreatitis, pancreatic necrosis and secondary infection of surrounding tissues can quickly spread to the whole ...

laparoscopic-left-hemihepatectomy-combined-with-caudate-lobe-resection

Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection

Intrahepatic cholangiocarcinoma (ICC) is the common malignant tumor of the liver. Radical surgical resection is the mainstay of potentially curative ...

function-preserving-laparoscopic-local-resection-duodenal-papillary

Function-Preserving Laparoscopic Local Resection of Duodenal Papillary Adenomas

Duodenal papillary adenomas, although rare, have significant potential for malignant transformation, necessitating precise intervention. Current surgical ...

Meizhou People’s Hospital

Meizhou People's Hospital

Meizhou Clinical Institute of Shantou University Medical College

Hepatocellular carcinoma (HCC) remains a major challenge for public health worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models are urgently needed. To identify a robust prognostic gene signature, we conduct this study.

Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma.

While hundreds of consistently altered metabolic genes had been identified in hepatocellular carcinoma (HCC), the prognostic role of them remains to be further elucidated. Messenger RNA expression profiles and clinicopathological data were downloaded from The Cancer Genome Atlas-Liver Hepatocellular Carcinoma and GSE14520 data set from the Gene Expression Omnibus database. Univariate Cox regression analysis and lasso Cox regression model established a novel four-gene metabolic signature (including acetyl-CoA acetyltransferase 1, glutamic-oxaloacetic transaminase 2, phosphatidylserine synthase 2, and uridine-cytidine kinase 2) for HCC prognosis prediction. Patients in the high-risk group shown significantly poorer survival than patients in the low-risk group. The signature was significantly correlated with other negative prognostic factors such as higher α-fetoprotein. The signature was found to be an independent prognostic factor for HCC survival. Nomogram including the signature shown some clinical net benefit for overall survival prediction. Furthermore, gene set enrichment analyses revealed several significantly enriched pathways, which might help explain the underlying mechanisms. Our study identified a novel robust four-gene metabolic signature for HCC prognosis prediction. The signature might reflect the dysregulated metabolic microenvironment and provided potential biomarkers for metabolic therapy and treatment response prediction in HCC.

Identification of a four-gene metabolic signature predicting overall survival for hepatocellular carcinoma.

Accumulating evidence indicates a strong correlation between type 2 diabetes mellitus (T2DM) and hepatocellular carcinoma (HCC), but the underlying pathophysiology is still elusive. We aimed to identify unrecognized but important genes and pathways related to T2DM and HCC by bioinformatic analysis. The GSE64998 and GSE15653 datasets (for T2DM), the GSE121248 dataset and the Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset (for HCC) were downloaded. Differential expression analysis, functional and pathway enrichment analysis, protein-protein interaction (PPI) network construction, survival analysis, transcription factor (TF) prediction, and correlation of gene expression with methylation and tumour-infiltrating immune cells were conducted. Nine genes, namely, CDNF, CRELD2, DNAJB11, DTL, GINS2, MANF, PDIA4, PDIA6, and VCP, were recognized as hub genes. Enrichment analysis revealed several enriched terms and pathways. Transcription factors such as Kruppel-like factor 6, abnormal methylation and immune dysregulation might help explain the dysregulation of hub genes. Our study identified nine hub genes that might play a critical role in both T2DM and HCC. However, more studies are warranted to clarify the mechanisms of these genes.

Key genes associated with diabetes mellitus and hepatocellular carcinoma.

N6-methyladenosine (m6A), the most prominent mRNA modification, plays a critical role in many physiological and pathological processes. However, the roles of m6A RNA modification in hepatocellular carcinoma (HCC) remain largely unknown.

Identification of METTL3 as an Adverse Prognostic Biomarker in Hepatocellular Carcinoma.

One of the most common cancers is hepatocellular carcinoma (HCC), which is an aggressive cancer that is associated with high mortality. The expression and role of ARHGAP20 in HCC remain unclear.

ARHGAP20 Expression Inhibited HCC Progression by Regulating the PI3K-AKT Signaling Pathway.

Limited data are available regarding ALI's clinical relevance and prognostic value in patients with hepatocellular carcinoma (HCC) after hepatectomy.

Advanced lung cancer inflammation index predicts overall survival of hepatocellular carcinoma after hepatectomy.

Insulin resistance is important in hepatocellular carcinoma (HCC) carcinogenesis and progression. The triglyceride-glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-c) ratio or TyG-body mass index (TyG-BMI) are three non-invasive parameters for insulin resistance. However, their prognostic role in HCC patients undergoing hepatectomy remains unclear.

ArticleTotal : 3	Year
Publication title Cited by 1	2024
Publication title	2025
Publication title	2025

Article	Year
Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma. Cancer cell international\| PubMed ID: 31139015	2019
Identification of a four-gene metabolic signature predicting overall survival for hepatocellular carcinoma. Journal of cellular physiology\| PubMed ID: 31309563	2020
Key genes associated with diabetes mellitus and hepatocellular carcinoma. Pathology, research and practice\| PubMed ID: 31591054	2019
Identification of METTL3 as an Adverse Prognostic Biomarker in Hepatocellular Carcinoma. Digestive diseases and sciences\| PubMed ID: 32333311	2021
ARHGAP20 Expression Inhibited HCC Progression by Regulating the PI3K-AKT Signaling Pathway. Journal of hepatocellular carcinoma\| PubMed ID: 33907697	2021
Advanced lung cancer inflammation index predicts overall survival of hepatocellular carcinoma after hepatectomy. Frontiers in oncology\| PubMed ID: 38390261	2024
Triglyceride-glucose index predicts postoperative overall survival in hepatocellular carcinoma: a retrospective cohort study. Discover oncology\| PubMed ID: 39537878	2024

Ji-Wei Xu

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