retroperitoneal-laparoscopic-debridement-drainage-for-pancreatic

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess

In patients with severe necrotizing pancreatitis, pancreatic necrosis and secondary infection of surrounding tissues can quickly spread to the whole ...

laparoscopic-left-hemihepatectomy-combined-with-caudate-lobe-resection

Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection

Intrahepatic cholangiocarcinoma (ICC) is the common malignant tumor of the liver. Radical surgical resection is the mainstay of potentially curative ...

function-preserving-laparoscopic-local-resection-duodenal-papillary

Function-Preserving Laparoscopic Local Resection of Duodenal Papillary Adenomas

Duodenal papillary adenomas, although rare, have significant potential for malignant transformation, necessitating precise intervention. Current surgical ...

Meizhou People’s Hospital

Meizhou People's Hospital

Hepatocellular carcinoma (HCC) remains a major challenge for public health worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models are urgently needed. To identify a robust prognostic gene signature, we conduct this study.

Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma.

Accumulating evidence indicates a strong correlation between type 2 diabetes mellitus (T2DM) and hepatocellular carcinoma (HCC), but the underlying pathophysiology is still elusive. We aimed to identify unrecognized but important genes and pathways related to T2DM and HCC by bioinformatic analysis. The GSE64998 and GSE15653 datasets (for T2DM), the GSE121248 dataset and the Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset (for HCC) were downloaded. Differential expression analysis, functional and pathway enrichment analysis, protein-protein interaction (PPI) network construction, survival analysis, transcription factor (TF) prediction, and correlation of gene expression with methylation and tumour-infiltrating immune cells were conducted. Nine genes, namely, CDNF, CRELD2, DNAJB11, DTL, GINS2, MANF, PDIA4, PDIA6, and VCP, were recognized as hub genes. Enrichment analysis revealed several enriched terms and pathways. Transcription factors such as Kruppel-like factor 6, abnormal methylation and immune dysregulation might help explain the dysregulation of hub genes. Our study identified nine hub genes that might play a critical role in both T2DM and HCC. However, more studies are warranted to clarify the mechanisms of these genes.

Key genes associated with diabetes mellitus and hepatocellular carcinoma.

N6-methyladenosine (m6A), the most prominent mRNA modification, plays a critical role in many physiological and pathological processes. However, the roles of m6A RNA modification in hepatocellular carcinoma (HCC) remain largely unknown.

ArticleTotal : 3	Year
Publication title Cited by 1	2024
Publication title	2025
Publication title	2025

Article	Year
Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma. Cancer cell international\| PubMed ID: 31139015	2019
Key genes associated with diabetes mellitus and hepatocellular carcinoma. Pathology, research and practice\| PubMed ID: 31591054	2019
Identification of METTL3 as an Adverse Prognostic Biomarker in Hepatocellular Carcinoma. Digestive diseases and sciences\| PubMed ID: 32333311	2021

Hua-Dong Zeng

Biography

JoVE Journal Publications

Other Publications