Piruthivi Sukumar

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation. Molecular cell\| PubMed ID: 16209944	2005
A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. Circulation research\| PubMed ID: 16675717	2006
TRPC channel activation by extracellular thioredoxin. Nature\| PubMed ID: 18172497	2008
Channel regulation by extracellular redox protein. Channels (Austin, Tex.)\| PubMed ID: 18690048	2007
Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. Circulation research\| PubMed ID: 18802022	2008
Robotic multiwell planar patch-clamp for native and primary mammalian cells. Nature protocols\| PubMed ID: 19197268	2009
Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+). Biochemical and biophysical research communications\| PubMed ID: 20100462	2010
Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. Circulation research\| PubMed ID: 20360246	2010
Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Pflugers Archiv : European journal of physiology\| PubMed ID: 20390293	2010
TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan. BMC musculoskeletal disorders\| PubMed ID: 20525329	2010
Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers. Cardiovascular research\| PubMed ID: 20884640	2011
Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration. Diabetes\| PubMed ID: 21317296	2011
Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels. Molecular pharmacology\| PubMed ID: 21406603	2011
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes\| PubMed ID: 21677284	2011
Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis. Diabetes\| PubMed ID: 22357965	2012
Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin. Circulation research\| PubMed ID: 22668831	2012
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice. Diabetes\| PubMed ID: 22733797	2012
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes\| PubMed ID: 23349484	2013
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species. Atherosclerosis\| PubMed ID: 23958265	2013
Response to Comment on: Sukumar et al. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes 2013;62:2130-2134. Diabetes\| PubMed ID: 24264411	2013
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem cells (Dayton, Ohio)\| PubMed ID: 24916783	2014
Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25012136	2014
Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop. Circulation research\| PubMed ID: 27920123	2017
Disaggregation of Amylin Aggregate by Novel Conformationally Restricted Aminobenzoic Acid containing α/β and α/γ Hybrid Peptidomimetics. Scientific reports\| PubMed ID: 28054630	2017
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Diabetes\| PubMed ID: 28830894	2017
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance. Nature communications\| PubMed ID: 28839146	2017
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice. Endocrinology\| PubMed ID: 29796592	2018
Piezo1 channel activation mimics high glucose as a stimulator of insulin release. Scientific reports\| PubMed ID: 31727906	2019
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage. American journal of physiology. Cell physiology\| PubMed ID: 32401607	2020
Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling. Life sciences\| PubMed ID: 32882268	2020
Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy. Journal of the American Heart Association\| PubMed ID: 32892688	2020
Systems analysis of avascular necrosis of femoral head using integrative data analysis and literature mining delineates pathways associated with disease. Scientific reports\| PubMed ID: 33093559	2020
Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism. Cell death & disease\| PubMed ID: 33828089	2021
Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity. EMBO reports\| PubMed ID: 33934497	2021
Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma. Scientific reports\| PubMed ID: 33963197	2021
Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat. Circulation research\| PubMed ID: 34420367	2021
Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling. Endocrinology\| PubMed ID: 34460911	2021
Author Correction: Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glauc... Scientific reports\| PubMed ID: 34480064	2021
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine. Annual review of pharmacology and toxicology\| PubMed ID: 34499525	2022
Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity. The Journal of clinical investigation\| PubMed ID: 35025768	2022
Elevated ATP, cytokines and potential microglial inflammation distinguish exfoliation glaucoma from exfoliation syndrome. Cytokine\| PubMed ID: 35074716	2022
Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity. Adipocyte\| PubMed ID: 35734881	2022