Richard Cubbon

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
The impact of insulin resistance on endothelial function, progenitor cells and repair. Diabetes & vascular disease research\| PubMed ID: 17654443	2007
Aspirin and mortality in patients with diabetes sustaining acute coronary syndrome. Diabetes care\| PubMed ID: 17959865	2008
Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event. PloS one\| PubMed ID: 18941531	2008
Cardiac resynchronisation therapy for chronic heart failure and conduction delay. BMJ (Clinical research ed.)\| PubMed ID: 19401320	2009
Vascular insulin-like growth factor-I resistance and diet-induced obesity. Endocrinology\| PubMed ID: 19608653	2009
Effects of insulin resistance on endothelial progenitor cells and vascular repair. Clinical science (London, England : 1979)\| PubMed ID: 19630751	2009
Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20110574	2010
Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration. Diabetes\| PubMed ID: 21317296	2011
Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation. Circulation research\| PubMed ID: 21441136	2011
Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras. Circulation. Heart failure\| PubMed ID: 21562056	2011
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes\| PubMed ID: 21677284	2011
Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans. Experimental physiology\| PubMed ID: 22179420	2012
Insulin- and growth factor-resistance impairs vascular regeneration in diabetes mellitus. Current vascular pharmacology\| PubMed ID: 22239629	2012
Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis. Diabetes\| PubMed ID: 22357965	2012
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice. Diabetes\| PubMed ID: 22733797	2012
Moderate and heavy metabolic stress interval training improve arterial stiffness and heart rate dynamics in humans. European journal of applied physiology\| PubMed ID: 22983616	2013
Gender-specific alterations in fibrin structure function in type 2 diabetes: associations with cardiometabolic and vascular markers. The Journal of clinical endocrinology and metabolism\| PubMed ID: 22996148	2012
Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology. Diabetes & vascular disease research\| PubMed ID: 23349368	2013
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes\| PubMed ID: 23349484	2013
Importance of insulin resistance to vascular repair and regeneration. Free radical biology & medicine\| PubMed ID: 23466555	2013
Cardiac resynchronization therapy in pacemaker-dependent patients with left ventricular dysfunction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 23736807	2013
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species. Atherosclerosis\| PubMed ID: 23958265	2013
Pacing-associated left ventricular dysfunction? Think reprogramming first! Heart (British Cardiac Society)\| PubMed ID: 24430095	2014
Calcium, phosphate and calcium phosphate product are markers of outcome in patients with chronic heart failure. Journal of nephrology\| PubMed ID: 24615401	2015
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem cells (Dayton, Ohio)\| PubMed ID: 24916783	2014
Patients with long-term permanent pacemakers have a high prevalence of left ventricular dysfunction. Journal of cardiovascular medicine (Hagerstown, Md.)\| PubMed ID: 24979115	2015
Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25012136	2014
Piezo1 integration of vascular architecture with physiological force. Nature\| PubMed ID: 25119035	2014
Sudden cardiac death in patients with diabetes mellitus and chronic heart failure. Diabetes & vascular disease research\| PubMed ID: 25861812	2015
An evaluation of 20 year survival in patients with diabetes mellitus and acute myocardial infarction. International journal of cardiology\| PubMed ID: 26512829	2016
Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Heart (British Cardiac Society)\| PubMed ID: 26674986	2016
Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance. Trends in endocrinology and metabolism: TEM\| PubMed ID: 26712712	2016
Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification. Heart (British Cardiac Society)\| PubMed ID: 26857212	2016
Cardio-oncology: Concepts and practice. Indian heart journal\| PubMed ID: 27056658	2016
Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study. Journal of the American College of Cardiology\| PubMed ID: 27058906	2016
Chronotropic Incompetence Does Not Limit Exercise Capacity in Chronic Heart Failure. Journal of the American College of Cardiology\| PubMed ID: 27102504	2016
Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction. Diabetes & vascular disease research\| PubMed ID: 27334485	2016
Pericytes in diabetes-associated vascular disease. Journal of diabetes and its complications\| PubMed ID: 27592245	2016
Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop. Circulation research\| PubMed ID: 27920123	2017
Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain. Diabetes\| PubMed ID: 28108607	2017
Role of glutamine and interlinked asparagine metabolism in vessel formation. The EMBO journal\| PubMed ID: 28659375	2017
Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nature genetics\| PubMed ID: 28714975	2017
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Diabetes\| PubMed ID: 28830894	2017
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance. Nature communications\| PubMed ID: 28839146	2017
Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes. Diabetes care\| PubMed ID: 28982651	2018
Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance. Endocrinology\| PubMed ID: 29186427	2018
Rate-Response Programming Tailored to the Force-Frequency Relationship Improves Exercise Tolerance in Chronic Heart Failure. JACC. Heart failure\| PubMed ID: 29226818	2018
Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure. Heart (British Cardiac Society)\| PubMed ID: 29386325	2018
Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin. Scientific reports\| PubMed ID: 29765077	2018
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice. Endocrinology\| PubMed ID: 29796592	2018
Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure. European journal of nutrition\| PubMed ID: 30121806	2019
Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis. Cell metabolism\| PubMed ID: 30146488	2018
Role of glutamine synthetase in angiogenesis beyond glutamine synthesis. Nature\| PubMed ID: 30158707	2018
Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries. Diabetes & vascular disease research\| PubMed ID: 30295509	2019
Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 30371261	2018
Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 30371286	2018
Prospective evaluation and long-term follow-up of patients referred to secondary care based upon natriuretic peptide levels in primary care. European heart journal. Quality of care & clinical outcomes\| PubMed ID: 30452611	2019
Prognostic Significance of Incidental Nonsustained Ventricular Tachycardia Detected on Pacemaker Interrogation. The American journal of cardiology\| PubMed ID: 30473328	2019
Predicting one-year mortality in heart failure using the 'Surprise Question': a prospective pilot study. European journal of heart failure\| PubMed ID: 30548129	2019
Contemporary treatment strategies for Type 2 diabetes-related macrovascular disease. Expert review of endocrinology & metabolism\| PubMed ID: 30736201	2014
Optimising pacemaker therapy and medical therapy in pacemaker patients for heart failure: protocol for the OPT-PACE randomised controlled trial. BMJ open\| PubMed ID: 31320354	2019
Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 31430834	2020
Chronic heart failure with diabetes mellitus is characterized by a severe skeletal muscle pathology. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 31863644	2020
Inorganic Nitrate Promotes Glucose Uptake and Oxidative Catabolism in White Adipose Tissue Through the XOR-Catalyzed Nitric Oxide Pathway. Diabetes\| PubMed ID: 32086288	2020
IGFBP-1 in Cardiometabolic Pathophysiology-Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice. Journal of the Endocrine Society\| PubMed ID: 32190801	2020
Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Devices and Heart Failure: A Phase II Study. Circulation\| PubMed ID: 32299222	2020
Infection-Related Hospitalization in Heart Failure With Reduced Ejection Fraction: A Prospective Observational Cohort Study. Circulation. Heart failure\| PubMed ID: 32354281	2020
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage. American journal of physiology. Cell physiology\| PubMed ID: 32401607	2020
Cardiovascular mortality and morbidity following radical radiotherapy for lung cancer: Is cardiovascular death under-reported? Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 32460218	2020
Prioritizing symptom management in the treatment of chronic heart failure. ESC heart failure\| PubMed ID: 32757363	2020
Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy. Journal of the American Heart Association\| PubMed ID: 32892688	2020
Effect of disease-modifying agents and their association with mortality in multi-morbid patients with heart failure with reduced ejection fraction. ESC heart failure\| PubMed ID: 32924331	2020
Association of heart failure and its comorbidities with loss of life expectancy. Heart (British Cardiac Society)\| PubMed ID: 33153996	2021
Response by Gierula et al to Letter Regarding Article, "Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Device... Circulation\| PubMed ID: 33166218	2020
Dose-dependent oral glucocorticoid cardiovascular risks in people with immune-mediated inflammatory diseases: A population-based cohort study. PLoS medicine\| PubMed ID: 33270649	2020
Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data. BMC palliative care\| PubMed ID: 33430850	2021
Diabetes, gender and deterioration in estimated glomerular filtration rate in patients with chronic heart failure: Ten-year prospective cohort study. Diabetes & vascular disease research\| PubMed ID: 33588611	2021
Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort study. The Lancet. Infectious diseases\| PubMed ID: 33662324	2021
Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity. EMBO reports\| PubMed ID: 33934497	2021
Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis. Endocrinology\| PubMed ID: 34037749	2021
Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34183396	2021
Impact of QRS duration on left ventricular remodelling and survival in patients with heart failure. Journal of cardiovascular medicine (Hagerstown, Md.)\| PubMed ID: 34261079	2021
Suboptimal Dosing of β-Blockers in Chronic Heart Failure: A Missed Opportunity? The Journal of cardiovascular nursing\| PubMed ID: 34321430	2022
Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat. Circulation research\| PubMed ID: 34420367	2021
Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling. Endocrinology\| PubMed ID: 34460911	2021
Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes. Diabetes\| PubMed ID: 34610982	2021
Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study. Journal of the American Heart Association\| PubMed ID: 34743561	2021
Personalised reprogramming to prevent progressive pacemaker-related left ventricular dysfunction: A phase II randomised, controlled clinical trial. PloS one\| PubMed ID: 34898655	2021
Hypoxia signalling in the regulation of innate immune training. Biochemical Society transactions\| PubMed ID: 35015075	2022
Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation. Health technology assessment (Winchester, England)\| PubMed ID: 35076012	2022
Endothelial Cell Fibrin Gel Angiogenesis Bead Assay. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35099748	2022
Prospective Longitudinal Characterization of the Relationship between Diabetes and Cardiac Structural and Functional Changes. Cardiology research and practice\| PubMed ID: 35178251	2022
Diabetes mellitus and the causes of hospitalisation in people with heart failure. Diabetes & vascular disease research\| PubMed ID: 35236158	2022
Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes. Obesity (Silver Spring, Md.)\| PubMed ID: 35357083	2022
Systemic Inflammation Is Associated With Future Risk of Fatal Infection: An Observational Cohort Study. The Journal of infectious diseases\| PubMed ID: 35535512	2022
Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity. Adipocyte\| PubMed ID: 35734881	2022
Guideline-directed medical therapy is similarly effective in heart failure with mildly reduced ejection fraction. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 35781605	2023
Coexistent Diabetes Is Associated With the Presence of Adverse Phenotypic Features in Patients With Hypertrophic Cardiomyopathy. Diabetes care\| PubMed ID: 35789379	2022
Atrial fibrillation and risk of progressive heart failure in patients with preserved ejection fraction heart failure. ESC heart failure\| PubMed ID: 35790085	2022
Reduction of heart failure guideline-directed medication during hospitalization: prevalence, risk factors, and outcomes. ESC heart failure\| PubMed ID: 35796239	2022
Maternal Cardiac Changes in Women With Obesity and Gestational Diabetes Mellitus. Diabetes care\| PubMed ID: 36099225	2022
Correction: Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data. BMC palliative care\| PubMed ID: 36527047	2022
PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing. Communications biology\| PubMed ID: 37005489	2023
Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 37349903	2023
Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study. Diabetes care\| PubMed ID: 37368983	2023
Association Between Type 2 Diabetes and Changes in Myocardial Structure, Contractile Function, Energetics, and Blood Flow Before and After Aortic Valve Replacement in Patients With Severe Ao... Circulation\| PubMed ID: 37746744	2023
Molecular mechanisms of diabetic heart disease: Insights from transcriptomic technologies. Diabetes & vascular disease research\| PubMed ID: 38116627	2023
Inflammation, infection, and cardiovascular risk. Lancet (London, England)\| PubMed ID: 38492937	2024