Stephen Wheatcroft

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes\| PubMed ID: 17259371	2007
Inter-subject differences in constitutive expression levels of the clock gene in man. Diabetes & vascular disease research\| PubMed ID: 17469042	2007
The impact of insulin resistance on endothelial function, progenitor cells and repair. Diabetes & vascular disease research\| PubMed ID: 17654443	2007
Insulin resistance and endothelial cell dysfunction: studies in mammalian models. Experimental physiology\| PubMed ID: 17933859	2008
Effect of endothelium-specific insulin resistance on endothelial function in vivo. Diabetes\| PubMed ID: 18835939	2008
Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event. PloS one\| PubMed ID: 18941531	2008
IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis. Trends in endocrinology and metabolism: TEM\| PubMed ID: 19349193	2009
Vascular insulin-like growth factor-I resistance and diet-induced obesity. Endocrinology\| PubMed ID: 19608653	2009
Effects of insulin resistance on endothelial progenitor cells and vascular repair. Clinical science (London, England : 1979)\| PubMed ID: 19630751	2009
Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20110574	2010
Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. Circulation research\| PubMed ID: 20360246	2010
Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease. International journal of hypertension\| PubMed ID: 20981357	2010
Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration. Diabetes\| PubMed ID: 21317296	2011
OBTAIN: a study of the occurrence of bleeding and thrombosis during anti-platelet therapy in non-cardiac surgery. European journal of anaesthesiology\| PubMed ID: 21544024	2011
Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras. Circulation. Heart failure\| PubMed ID: 21562056	2011
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes\| PubMed ID: 21677284	2011
Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis. Diabetes\| PubMed ID: 22357965	2012
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice. Diabetes\| PubMed ID: 22733797	2012
The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence. The FEBS journal\| PubMed ID: 23095053	2012
A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PloS one\| PubMed ID: 23139789	2012
Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology. Diabetes & vascular disease research\| PubMed ID: 23349368	2013
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes\| PubMed ID: 23349484	2013
Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm. Diabetes\| PubMed ID: 23382450	2013
Teaching an old drug new tricks: can paroxetine ease the burden of cardiovascular disease in diabetes? Diabetes\| PubMed ID: 23431014	2013
Ankle pressures in UK South Asians with diabetes mellitus: a case control study. Heart (British Cardiac Society)\| PubMed ID: 23442538	2013
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species. Atherosclerosis\| PubMed ID: 23958265	2013
Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells. Methods in enzymology\| PubMed ID: 24377929	2014
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem cells (Dayton, Ohio)\| PubMed ID: 24916783	2014
VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions. Molecular biology of the cell\| PubMed ID: 24966171	2014
Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25012136	2014
In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis. PloS one\| PubMed ID: 25393739	2014
Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood\| PubMed ID: 25710879	2015
Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease. Journal of inherited metabolic disease\| PubMed ID: 25868665	2015
VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration. Biology open\| PubMed ID: 25910937	2015
Scavenger receptor structure and function in health and disease. Cells\| PubMed ID: 26010753	2015
Detection and Quantification of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases in Primary Human Endothelial Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26285745	2015
Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics. Journal of cardiovascular translational research\| PubMed ID: 26385009	2015
VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8. Traffic (Copenhagen, Denmark)\| PubMed ID: 26459808	2016
Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance. Trends in endocrinology and metabolism: TEM\| PubMed ID: 26712712	2016
VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis. Biology open\| PubMed ID: 27044325	2016
How We Measure Heart Rate: Does it Matter? The American journal of medicine\| PubMed ID: 27554964	2016
Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop. Circulation research\| PubMed ID: 27920123	2017
Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain. Diabetes\| PubMed ID: 28108607	2017
Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms. PloS one\| PubMed ID: 28472123	2017
Assessing Coronary Blood Flow Physiology in the Cardiac Catheterisation Laboratory. Current cardiology reviews\| PubMed ID: 28545351	2017
Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function. Biology open\| PubMed ID: 28798148	2017
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Diabetes\| PubMed ID: 28830894	2017
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance. Nature communications\| PubMed ID: 28839146	2017
Clinical outcomes following primary percutaneous coronary intervention for ST-elevation myocardial infarction according to sex and race. European heart journal. Acute cardiovascular care\| PubMed ID: 28980483	2019
Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance. Endocrinology\| PubMed ID: 29186427	2018
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice. Endocrinology\| PubMed ID: 29796592	2018
The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes. Molecular metabolism\| PubMed ID: 30392760	2019
TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice. Scientific reports\| PubMed ID: 30692584	2019
Insulin-like growth factor binding proteins and angiogenesis: from cancer to cardiovascular disease. Cytokine & growth factor reviews\| PubMed ID: 30954375	2019
Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function. Biology open\| PubMed ID: 31072823	2019
Real-world comparison of clopidogrel, prasugrel and ticagrelor in patients undergoing primary percutaneous coronary intervention. Open heart\| PubMed ID: 31328001	2019
Prescribing diabetes medication for cardiovascular risk reduction in patients admitted with acute coronary syndromes: a survey of cardiologists' attitudes and practice. European heart journal. Cardiovascular pharmacotherapy\| PubMed ID: 31702003	2020
IGFBP-1 in Cardiometabolic Pathophysiology-Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice. Journal of the Endocrine Society\| PubMed ID: 32190801	2020
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage. American journal of physiology. Cell physiology\| PubMed ID: 32401607	2020
Direct oral anticoagulants compared to vitamin K antagonist for the management of left ventricular thrombus. ESC heart failure\| PubMed ID: 32583975	2020
Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy. Journal of the American Heart Association\| PubMed ID: 32892688	2020
Advantages of CEMiTool for gene co-expression analysis of RNA-seq data. Computers in biology and medicine\| PubMed ID: 32911277	2020
Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity. EMBO reports\| PubMed ID: 33934497	2021
Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis. Endocrinology\| PubMed ID: 34037749	2021
Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat. Circulation research\| PubMed ID: 34420367	2021
Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling. Endocrinology\| PubMed ID: 34460911	2021
Meta-Analysis Comparing 10-Year Mortality Following Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting in Left Main Stem or Multivessel Coronary Artery Disease. The American journal of cardiology\| PubMed ID: 35504742	2022
Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity. Adipocyte\| PubMed ID: 35734881	2022
Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarctio... Circulation\| PubMed ID: 36039762	2022
Meta-Analysis Comparing Clinical Outcomes of Fractional-Flow-Reserve- and Angiography-Guided Multivessel Percutaneous Coronary Intervention. The American journal of cardiology\| PubMed ID: 36184352	2022
Association between operator volume and mortality in primary percutaneous coronary intervention. Open heart\| PubMed ID: 36192035	2022
Safety and efficacy of interrupting dual antiplatelet therapy one month following percutaneous coronary intervention: a meta-analysis of randomized controlled trials. BMC cardiovascular disorders\| PubMed ID: 36307769	2022
Management of non-ST-segment elevation myocardial infarction in patients aged ≥ 80 years: a meta-analysis of randomized controlled trials. Journal of geriatric cardiology : JGC\| PubMed ID: 36338285	2022
Imaging Real-Time Coronary Anatomy Using a Three-Dimensional Electrophysiology Mapping System. Journal of cardiovascular translational research\| PubMed ID: 36414925	2023
Fractional Flow Reserve versus Angiography-Guided Management of Coronary Artery Disease: A Meta-Analysis of Contemporary Randomised Controlled Trials. Journal of clinical medicine\| PubMed ID: 36498667	2022
Improving the management of left ventricular thrombus in a tertiary cardiology centre: a quality improvement project. BMJ open quality\| PubMed ID: 36631136	2023
Clinical validation and evaluation of a novel six-lead handheld electrocardiogram recorder compared to the 12-lead electrocardiogram in unselected cardiology patients (EVALECG Cardio). European heart journal. Digital health\| PubMed ID: 36713105	2021
Transcoronary electrophysiological parameters in patients undergoing elective and acute coronary intervention. PloS one\| PubMed ID: 36745641	2023
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis. Cell reports. Medicine\| PubMed ID: 36787736	2023
Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study. Diabetes care\| PubMed ID: 37368983	2023
Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention on Medium-Term Outcomes: A Contemporary Meta-Analysis of Randomized Controlled Trials. The American journal of cardiology\| PubMed ID: 37481812	2023
Coronary Guidewires in Temporary Cardiac Pacing and Assessment of Myocardial Viability: Current Perspectives and Future Directions. Journal of clinical medicine\| PubMed ID: 38002591	2023
Sodium-glucose cotransporter 2 inhibitors influence skeletal muscle pathology in patients with heart failure and reduced ejection fraction. European journal of heart failure\| PubMed ID: 38468429	2024