Mark T. Kearney

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds

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Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Somatostatin receptor subtype expression in the human heart: differential expression by myocytes and fibroblasts. The Journal of endocrinology\| PubMed ID: 16423817	2005
IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes\| PubMed ID: 17259371	2007
Inter-subject differences in constitutive expression levels of the clock gene in man. Diabetes & vascular disease research\| PubMed ID: 17469042	2007
Insulin resistance and endothelial cell dysfunction: studies in mammalian models. Experimental physiology\| PubMed ID: 17933859	2008
Aspirin and mortality in patients with diabetes sustaining acute coronary syndrome. Diabetes care\| PubMed ID: 17959865	2008
Role of IGF-1 in glucose regulation and cardiovascular disease. Expert review of cardiovascular therapy\| PubMed ID: 18793116	2008
Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event. PloS one\| PubMed ID: 18941531	2008
IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis. Trends in endocrinology and metabolism: TEM\| PubMed ID: 19349193	2009
Vascular insulin-like growth factor-I resistance and diet-induced obesity. Endocrinology\| PubMed ID: 19608653	2009
Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse. Atherosclerosis\| PubMed ID: 20003977	2010
Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20110574	2010
Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. Circulation research\| PubMed ID: 20360246	2010
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. Expert opinion on therapeutic targets\| PubMed ID: 21058922	2010
Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration. Diabetes\| PubMed ID: 21317296	2011
Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation. Circulation research\| PubMed ID: 21441136	2011
Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras. Circulation. Heart failure\| PubMed ID: 21562056	2011
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes\| PubMed ID: 21677284	2011
Insulin- and growth factor-resistance impairs vascular regeneration in diabetes mellitus. Current vascular pharmacology\| PubMed ID: 22239629	2012
Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis. Diabetes\| PubMed ID: 22357965	2012
Sympathetic activation and vasoregulation in response to carbohydrate ingestion in patients with congestive heart failure. The Canadian journal of cardiology\| PubMed ID: 22652092	2013
Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin. Circulation research\| PubMed ID: 22668831	2012
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice. Diabetes\| PubMed ID: 22733797	2012
A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PloS one\| PubMed ID: 23139789	2012
Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology. Diabetes & vascular disease research\| PubMed ID: 23349368	2013
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes\| PubMed ID: 23349484	2013
Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm. Diabetes\| PubMed ID: 23382450	2013
Importance of insulin resistance to vascular repair and regeneration. Free radical biology & medicine\| PubMed ID: 23466555	2013
Changing the way we think about endothelial cell insulin sensitivity, nitric oxide, and the pathophysiology of type 2 diabetes: the FoxO is loose. Diabetes\| PubMed ID: 23613560	2013
Cardiac resynchronization therapy in pacemaker-dependent patients with left ventricular dysfunction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 23736807	2013
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species. Atherosclerosis\| PubMed ID: 23958265	2013
Response to Comment on: Sukumar et al. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes 2013;62:2130-2134. Diabetes\| PubMed ID: 24264411	2013
Pacing-associated left ventricular dysfunction? Think reprogramming first! Heart (British Cardiac Society)\| PubMed ID: 24430095	2014
Calcium, phosphate and calcium phosphate product are markers of outcome in patients with chronic heart failure. Journal of nephrology\| PubMed ID: 24615401	2015
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem cells (Dayton, Ohio)\| PubMed ID: 24916783	2014
Patients with long-term permanent pacemakers have a high prevalence of left ventricular dysfunction. Journal of cardiovascular medicine (Hagerstown, Md.)\| PubMed ID: 24979115	2015
Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25012136	2014
The microvascular effects of insulin resistance and diabetes on cardiac structure, function, and perfusion: a cardiovascular magnetic resonance study. European heart journal. Cardiovascular Imaging\| PubMed ID: 25117473	2014
Piezo1 integration of vascular architecture with physiological force. Nature\| PubMed ID: 25119035	2014
In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis. PloS one\| PubMed ID: 25393739	2014
Chronic heart failure and type 2 diabetes mellitus: The last battle? Diabetes & vascular disease research\| PubMed ID: 26099813	2015
Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26160956	2015
An evaluation of 20 year survival in patients with diabetes mellitus and acute myocardial infarction. International journal of cardiology\| PubMed ID: 26512829	2016
Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Heart (British Cardiac Society)\| PubMed ID: 26674986	2016
Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance. Trends in endocrinology and metabolism: TEM\| PubMed ID: 26712712	2016
Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification. Heart (British Cardiac Society)\| PubMed ID: 26857212	2016
VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis. Biology open\| PubMed ID: 27044325	2016
Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study. Journal of the American College of Cardiology\| PubMed ID: 27058906	2016
Chronotropic Incompetence Does Not Limit Exercise Capacity in Chronic Heart Failure. Journal of the American College of Cardiology\| PubMed ID: 27102504	2016
A Novel and Practical Screening Tool for the Detection of Silent Myocardial Infarction in Patients With Type 2 Diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 27300573	2016
Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction. Diabetes & vascular disease research\| PubMed ID: 27334485	2016
Lung Function Abnormalities in Smokers with Ischemic Heart Disease. American journal of respiratory and critical care medicine\| PubMed ID: 27442601	2016
Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop. Circulation research\| PubMed ID: 27920123	2017
Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain. Diabetes\| PubMed ID: 28108607	2017
Diabetes mellitus and heart failure: a deadly duo. Journal of thoracic disease\| PubMed ID: 28203401	2017
Response by Viswambharan and Kearney to Letter Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop". Circulation research\| PubMed ID: 28209800	2017
Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28596376	2017
Diabetes Mellitus, Microalbuminuria, and Subclinical Cardiac Disease: Identification and Monitoring of Individuals at Risk of Heart Failure. Journal of the American Heart Association\| PubMed ID: 28716801	2017
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Diabetes\| PubMed ID: 28830894	2017
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance. Nature communications\| PubMed ID: 28839146	2017
Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes. Diabetes care\| PubMed ID: 28982651	2018
Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance. Endocrinology\| PubMed ID: 29186427	2018
Rate-Response Programming Tailored to the Force-Frequency Relationship Improves Exercise Tolerance in Chronic Heart Failure. JACC. Heart failure\| PubMed ID: 29226818	2018
Devices in heart failure; diagnosis, detection and disease modification. British medical bulletin\| PubMed ID: 29342243	2018
Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure. Heart (British Cardiac Society)\| PubMed ID: 29386325	2018
Cardiovascular magnetic resonance measures of aortic stiffness in asymptomatic patients with type 2 diabetes: association with glycaemic control and clinical outcomes. Cardiovascular diabetology\| PubMed ID: 29506523	2018
Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin. Scientific reports\| PubMed ID: 29765077	2018
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice. Endocrinology\| PubMed ID: 29796592	2018
Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure. European journal of nutrition\| PubMed ID: 30121806	2019
Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries. Diabetes & vascular disease research\| PubMed ID: 30295509	2019
Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity. Free radical biology & medicine\| PubMed ID: 30342191	2018
Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 30371261	2018
Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 30371286	2018
Prospective evaluation and long-term follow-up of patients referred to secondary care based upon natriuretic peptide levels in primary care. European heart journal. Quality of care & clinical outcomes\| PubMed ID: 30452611	2019
Prognostic Significance of Incidental Nonsustained Ventricular Tachycardia Detected on Pacemaker Interrogation. The American journal of cardiology\| PubMed ID: 30473328	2019
TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice. Scientific reports\| PubMed ID: 30692584	2019
Contemporary treatment strategies for Type 2 diabetes-related macrovascular disease. Expert review of endocrinology & metabolism\| PubMed ID: 30736201	2014
Heart failure: A preventable and treatable complication of type 2 diabetes. Journal of diabetes\| PubMed ID: 31037815	2019
Optimising pacemaker therapy and medical therapy in pacemaker patients for heart failure: protocol for the OPT-PACE randomised controlled trial. BMJ open\| PubMed ID: 31320354	2019
Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 31430834	2020
Piezo1 channel activation mimics high glucose as a stimulator of insulin release. Scientific reports\| PubMed ID: 31727906	2019
Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 31852424	2020
Chronic heart failure with diabetes mellitus is characterized by a severe skeletal muscle pathology. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 31863644	2020
Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca Handling After Pressure Overload. Circulation\| PubMed ID: 31906693	2020
Inorganic Nitrate Promotes Glucose Uptake and Oxidative Catabolism in White Adipose Tissue Through the XOR-Catalyzed Nitric Oxide Pathway. Diabetes\| PubMed ID: 32086288	2020
IGFBP-1 in Cardiometabolic Pathophysiology-Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice. Journal of the Endocrine Society\| PubMed ID: 32190801	2020
Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Devices and Heart Failure: A Phase II Study. Circulation\| PubMed ID: 32299222	2020
Infection-Related Hospitalization in Heart Failure With Reduced Ejection Fraction: A Prospective Observational Cohort Study. Circulation. Heart failure\| PubMed ID: 32354281	2020
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage. American journal of physiology. Cell physiology\| PubMed ID: 32401607	2020
Prioritizing symptom management in the treatment of chronic heart failure. ESC heart failure\| PubMed ID: 32757363	2020
Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy. Journal of the American Heart Association\| PubMed ID: 32892688	2020
Effect of disease-modifying agents and their association with mortality in multi-morbid patients with heart failure with reduced ejection fraction. ESC heart failure\| PubMed ID: 32924331	2020
Association of heart failure and its comorbidities with loss of life expectancy. Heart (British Cardiac Society)\| PubMed ID: 33153996	2021
Response by Gierula et al to Letter Regarding Article, "Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Device... Circulation\| PubMed ID: 33166218	2020
Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data. BMC palliative care\| PubMed ID: 33430850	2021
Diabetes, gender and deterioration in estimated glomerular filtration rate in patients with chronic heart failure: Ten-year prospective cohort study. Diabetes & vascular disease research\| PubMed ID: 33588611	2021
Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort study. The Lancet. Infectious diseases\| PubMed ID: 33662324	2021
Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity. EMBO reports\| PubMed ID: 33934497	2021
Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis. Endocrinology\| PubMed ID: 34037749	2021
Impact of QRS duration on left ventricular remodelling and survival in patients with heart failure. Journal of cardiovascular medicine (Hagerstown, Md.)\| PubMed ID: 34261079	2021
Suboptimal Dosing of β-Blockers in Chronic Heart Failure: A Missed Opportunity? The Journal of cardiovascular nursing\| PubMed ID: 34321430	2022
Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat. Circulation research\| PubMed ID: 34420367	2021
Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling. Endocrinology\| PubMed ID: 34460911	2021
Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Glucose Homeostasis and Diabetes-Related Endothelial Cell Dysfunction. Cells\| PubMed ID: 34571964	2021
Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study. Journal of the American Heart Association\| PubMed ID: 34743561	2021
Personalised reprogramming to prevent progressive pacemaker-related left ventricular dysfunction: A phase II randomised, controlled clinical trial. PloS one\| PubMed ID: 34898655	2021
Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity. The Journal of clinical investigation\| PubMed ID: 35025768	2022
Diabetes mellitus and the causes of hospitalisation in people with heart failure. Diabetes & vascular disease research\| PubMed ID: 35236158	2022
Systemic Inflammation Is Associated With Future Risk of Fatal Infection: An Observational Cohort Study. The Journal of infectious diseases\| PubMed ID: 35535512	2022
Paracrine Role of the Endothelium in Metabolic Homeostasis in Health and Nutrient Excess. Frontiers in cardiovascular medicine\| PubMed ID: 35557517	2022
Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR-IGF1R hybrid receptor modulators. RSC medicinal chemistry\| PubMed ID: 35647546	2022
Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity. Adipocyte\| PubMed ID: 35734881	2022
Guideline-directed medical therapy is similarly effective in heart failure with mildly reduced ejection fraction. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 35781605	2023
Atrial fibrillation and risk of progressive heart failure in patients with preserved ejection fraction heart failure. ESC heart failure\| PubMed ID: 35790085	2022
Reduction of heart failure guideline-directed medication during hospitalization: prevalence, risk factors, and outcomes. ESC heart failure\| PubMed ID: 35796239	2022
Efficacy of interval exercise training to improve vascular health in sedentary postmenopausal females. Physiological reports\| PubMed ID: 35986498	2022
Correction: Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data. BMC palliative care\| PubMed ID: 36527047	2022
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis. Cell reports. Medicine\| PubMed ID: 36787736	2023
Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, plac... EClinicalMedicine\| PubMed ID: 36864979	2023
Atrial secondary mitral regurgitation: prevalence, characteristics, management, and long-term outcomes. Echo research and practice\| PubMed ID: 36882790	2023
Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study. Diabetes care\| PubMed ID: 37368983	2023
Association Between Type 2 Diabetes and Changes in Myocardial Structure, Contractile Function, Energetics, and Blood Flow Before and After Aortic Valve Replacement in Patients With Severe Ao... Circulation\| PubMed ID: 37746744	2023