Rui Jorge Nobre

CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2024

Other Publications

Article	Year
Gene therapy for Parkinson's and Alzheimer's diseases: from the bench to clinical trials. Current pharmaceutical design\| PubMed ID: 21902665	2011
Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease. Human molecular genetics\| PubMed ID: 24817574	2014
Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 27637390	2016
Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line. Biochimica et biophysica acta. General subjects\| PubMed ID: 27939617	2017
Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 28687495	2017
Gene Therapies for Polyglutamine Diseases. Advances in experimental medicine and biology\| PubMed ID: 29427115	2018
Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 30087083	2018
Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders. Brain : a journal of neurology\| PubMed ID: 31738395	2020
Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies. The Journal of molecular diagnostics : JMD\| PubMed ID: 32205289	2020
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models. Journal of translational medicine\| PubMed ID: 32272938	2020
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples. Acta neuropathologica communications\| PubMed ID: 32867861	2020
Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research. Molecular therapy. Methods & clinical development\| PubMed ID: 32913880	2020
Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening. Pharmaceutics\| PubMed ID: 34683891	2021
miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3. Nucleic acid therapeutics\| PubMed ID: 34878314	2022
Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease. Acta neuropathologica communications\| PubMed ID: 35305685	2022
A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification. Gene therapy\| PubMed ID: 36316447	2022
Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation. Biomolecules\| PubMed ID: 36830647	2023
Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 37025062	2023
RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation. International journal of biological macromolecules\| PubMed ID: 38199539	2024
Viral-based animal models in polyglutamine disorders. Brain : a journal of neurology\| PubMed ID: 38284949	2024