Melissa C. Skala

Morgridge Institute for Research

Affiliated withMorgridge Institute for Research University of Wisconsin-Madison

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Autofluorescence flow sorting of breast cancer cell metabolism. Journal of biophotonics\| PubMed ID: 27730745	2017
Metabolic Imaging of Head and Neck Cancer Organoids. PloS one\| PubMed ID: 28099487	2017
Autofluorescence imaging identifies tumor cell-cycle status on a single-cell level. Journal of biophotonics\| PubMed ID: 28485124	2018
Functional Optical Imaging of Primary Human Tumor Organoids: Development of a Personalized Drug Screen. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 28588148	2017
In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye. Scientific reports\| PubMed ID: 28835698	2017
Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin. Scientific reports\| PubMed ID: 29348410	2018
Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon. Scientific reports\| PubMed ID: 29615678	2018
Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones. Biomedical optics express\| PubMed ID: 29675308	2018
Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 29930982	2018
Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography. Translational vision science & technology\| PubMed ID: 30197836	2018
BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML. Journal of cellular biochemistry\| PubMed ID: 30417424	2019
MTORC1/2 Inhibition as a Therapeutic Strategy for Mutant Cancers. Molecular cancer therapeutics\| PubMed ID: 30425131	2019
Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations. EBioMedicine\| PubMed ID: 30482722	2018
Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels. Advanced healthcare materials\| PubMed ID: 30565891	2019
Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines. Development (Cambridge, England)\| PubMed ID: 30567931	2019
Redox imaging and optical coherence tomography of the respiratory ciliated epithelium. Journal of biomedical optics\| PubMed ID: 30701725	2019
Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model. Oncoimmunology\| PubMed ID: 30723584	2019
Imaging intratumoral metabolic heterogeneity. Nature biomedical engineering\| PubMed ID: 31073174	2019
Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids. Neoplasia (New York, N.Y.)\| PubMed ID: 31078067	2019
Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents. Translational vision science & technology\| PubMed ID: 31131155	2019
Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 31175091	2019
Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells. Scientific reports\| PubMed ID: 31462653	2019
Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients. Lab on a chip\| PubMed ID: 31506657	2019
Classifying T cell activity in autofluorescence intensity images with convolutional neural networks. Journal of biophotonics\| PubMed ID: 31661592	2020
Sample preparation strategies for high-throughput mass spectrometry imaging of primary tumor organoids. Journal of mass spectrometry : JMS\| PubMed ID: 31661714	2020
Quantitative Spatial Analysis of Metabolic Heterogeneity Across and Tumor Models. Frontiers in oncology\| PubMed ID: 31737571	2019
Development of a Microfluidic Array to Study Drug Response in Breast Cancer. Molecules (Basel, Switzerland)\| PubMed ID: 31801265	2019
Human Tumor-Lymphatic Microfluidic Model Reveals Differential Conditioning of Lymphatic Vessels by Breast Cancer Cells. Advanced healthcare materials\| PubMed ID: 31894641	2020
Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications. Journal of biomedical optics\| PubMed ID: 32406215	2020
Label-free redox imaging of patient-derived organoids using selective plane illumination microscopy. Biomedical optics express\| PubMed ID: 32499946	2020
Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment. Frontiers in oncology\| PubMed ID: 32500020	2020
MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC. JCI insight\| PubMed ID: 32634121	2020
Classification of T-cell activation via autofluorescence lifetime imaging. Nature biomedical engineering\| PubMed ID: 32719514	2021
A bioengineered organotypic prostate model for the study of tumor microenvironment-induced immune cell activation. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 33034643	2020
Adaptable pulsatile flow generated from stem cell-derived cardiomyocytes using quantitative imaging-based signal transduction. Lab on a chip\| PubMed ID: 33048070	2020
Autofluorescence Imaging of 3D Tumor-Macrophage Microscale Cultures Resolves Spatial and Temporal Dynamics of Macrophage Metabolism. Cancer research\| PubMed ID: 33093167	2020
Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability. International journal of molecular sciences\| PubMed ID: 33260673	2020
Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells. PLoS pathogens\| PubMed ID: 33444400	2021
Microfluidic tumor-on-a-chip model to evaluate the role of tumor environmental stress on NK cell exhaustion. Science advances\| PubMed ID: 33597234	2021
Patient-derived cancer organoid tracking with wide-field one-photon redox imaging to assess treatment response. Journal of biomedical optics\| PubMed ID: 33754540	2021
The NIH Somatic Cell Genome Editing program. Nature\| PubMed ID: 33828315	2021
Autofluorescence Imaging of Treatment Response in Neuroendocrine Tumor Organoids. Cancers\| PubMed ID: 33919802	2021
Intravital Metabolic Autofluorescence Imaging Captures Macrophage Heterogeneity Across Normal and Cancerous Tissue. Frontiers in bioengineering and biotechnology\| PubMed ID: 33959597	2021
Extracellular pH affects the fluorescence lifetimes of metabolic co-factors. Journal of biomedical optics\| PubMed ID: 34032035	2021
Optical Coherence Tomography Angiography in the Thirteen-Lined Ground Squirrel. Translational vision science & technology\| PubMed ID: 34232271	2021
Recent innovations in fluorescence lifetime imaging microscopy for biology and medicine. Journal of biomedical optics\| PubMed ID: 34247457	2021
Label-free imaging for quality control of cardiomyocyte differentiation. Nature communications\| PubMed ID: 34321477	2021
Volumetric growth tracking of patient-derived cancer organoids using optical coherence tomography. Biomedical optics express\| PubMed ID: 34457380	2021
Maturation- and degeneration-dependent articular cartilage metabolism via optical redox ratio imaging. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 34792214	2022
Breast cancer immunotherapy: current biomarkers and the potential of assays. Current opinion in biomedical engineering\| PubMed ID: 34901585	2021
Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors. Science advances\| PubMed ID: 35061540	2022
In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish. eLife\| PubMed ID: 35200139	2022
Technologies to Assess Drug Response and Heterogeneity in Patient-Derived Cancer Organoids. Annual review of biomedical engineering\| PubMed ID: 35259932	2022
Microphysiological model of renal cell carcinoma to inform anti-angiogenic therapy. Biomaterials\| PubMed ID: 35299086	2022
Impact of baseline culture conditions of cancer organoids when determining therapeutic response and tumor heterogeneity. Scientific reports\| PubMed ID: 35338174	2022
Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system. Science advances\| PubMed ID: 35544643	2022
Label-Free Imaging to Track Reprogramming of Human Somatic Cells. GEN biotechnology\| PubMed ID: 35586336	2022
Inhibition of B-cell lymphoma 2 family proteins alters optical redox ratio, mitochondrial polarization, and cell energetics independent of cell state. Journal of biomedical optics\| PubMed ID: 35643815	2022
autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids. Biomedical optics express\| PubMed ID: 35781966	2022
Treatment Inequity: Examining the Influence of Non-Hispanic Black Race and Ethnicity on Pancreatic Cancer Care and Survival in Wisconsin. WMJ : official publication of the State Medical Society of Wisconsin\| PubMed ID: 35857681	2022
Prostate cancer cells demonstrate unique metabolism and substrate adaptability acutely after androgen deprivation therapy. The Prostate\| PubMed ID: 35980831	2022
Touch-free optical technologies to streamline the production of T cell therapies. Current opinion in biomedical engineering\| PubMed ID: 36642996	2023
Autofluorescence lifetime imaging classifies human lymphocyte activation and subtype. bioRxiv : the preprint server for biology\| PubMed ID: 36747690	2023
Light sheet autofluorescence lifetime imaging with a single photon avalanche diode array. bioRxiv : the preprint server for biology\| PubMed ID: 36778488	2023
Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology. Science advances\| PubMed ID: 36961891	2023
Single cell metabolic imaging of tumor and immune cells in melanoma bearing mice. Frontiers in oncology\| PubMed ID: 37020875	2023
Microphysiological head and neck cancer model identifies novel role of lymphatically secreted monocyte migration inhibitory factor in cancer cell migration and metabolism. Biomaterials\| PubMed ID: 37178589	2023
Optical coherence tomography of human fetal membrane sub-layers during loading. Biomedical optics express\| PubMed ID: 37342693	2023
Light-sheet autofluorescence lifetime imaging with a single-photon avalanche diode array. Journal of biomedical optics\| PubMed ID: 37351197	2023
Microfluidic device with reconfigurable spatial temporal gradients reveals plastic astrocyte response to stroke and reperfusion. Lab on a chip\| PubMed ID: 37448230	2023
Griddient: a microfluidic array to generate reconfigurable gradients on-demand for spatial biology applications. Communications biology\| PubMed ID: 37689746	2023
Preclinical Models of Anal Cancer Combined-Modality Therapy. The Journal of surgical research\| PubMed ID: 37864962	2024
Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV cancer. Nature communications\| PubMed ID: 37865647	2023
Label-free optical imaging and sensing for quality control of stem cell manufacturing. Current opinion in biomedical engineering\| PubMed ID: 37885458	2023
Author Correction: Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV cancer. Nature communications\| PubMed ID: 37949872	2023
Development of a multilayer fetal membrane material model calibrated using bulge inflation mechanical tests. Journal of the mechanical behavior of biomedical materials\| PubMed ID: 38160642	2024
Perspectives on label-free microscopy of heterogeneous and dynamic biological systems. Journal of biomedical optics\| PubMed ID: 38434231	2025
Autofluorescence is a biomarker of neural stem cell activation state. Cell stem cell\| PubMed ID: 38521057	2024
Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma. Cell reports. Medicine\| PubMed ID: 38554704	2024