Marianna A Tryfonidou

Department of Clinical Sciences, Utrecht University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2024

Other Publications

Article	Year
Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical. JOR spine\| PubMed ID: 31463447	2018
Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species. JOR spine\| PubMed ID: 31463445	2018
Inflammatory cytokines and the nuclear vitamin D receptor are implicated in the pathophysiology of dental resorptive lesions in cats. Veterinary immunology and immunopathology\| PubMed ID: 19556012	2009
Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats. European journal of oral sciences\| PubMed ID: 20156263	2010
Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 20858751	2010
Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 22083942	2012
Intervertebral disc degeneration in the dog. Part 2: chondrodystrophic and non-chondrodystrophic breeds. Veterinary journal (London, England : 1997)\| PubMed ID: 23154070	2013
Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration. Veterinary journal (London, England : 1997)\| PubMed ID: 23177522	2013
Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerati... Arthritis research & therapy\| PubMed ID: 23360510	2013
Increased osmolarity and cell clustering preserve canine notochordal cell phenotype in culture. Tissue engineering. Part C, Methods\| PubMed ID: 24304309	2014
Stem cells in the canine pituitary gland and in pituitary adenomas. The veterinary quarterly\| PubMed ID: 24320563	2013
Potential regenerative treatment strategies for intervertebral disc degeneration in dogs. BMC veterinary research\| PubMed ID: 24387033	2014
Genome wide analysis indicates genes for basement membrane and cartilage matrix proteins as candidates for hip dysplasia in Labrador Retrievers. PloS one\| PubMed ID: 24498183	2014
The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes. Journal of cellular physiology\| PubMed ID: 24777663	2014
Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells. Tissue engineering. Part A\| PubMed ID: 25370929	2015
The Effects of Naproxen on Chondrogenesis of Human Mesenchymal Stem Cells. Tissue engineering. Part A\| PubMed ID: 25873236	2015
Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration. Arthritis research & therapy\| PubMed ID: 25890127	2015
Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt. Veterinary journal (London, England : 1997)\| PubMed ID: 25920772	2015
Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. Veterinary journal (London, England : 1997)\| PubMed ID: 25956343	2015
Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration. Arthritis research & therapy\| PubMed ID: 26013758	2015
Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model. Arthritis research & therapy\| PubMed ID: 26290179	2015
The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs. European cells & materials\| PubMed ID: 26388616	2015
The Stimulatory Effect of Notochordal Cell-Conditioned Medium in a Nucleus Pulposus Explant Culture. Tissue engineering. Part A\| PubMed ID: 26421447	2016
Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow. Stem cells and development\| PubMed ID: 26462417	2016
Pedicle screw-rod fixation: a feasible treatment for dogs with severe degenerative lumbosacral stenosis. BMC veterinary research\| PubMed ID: 26642756	2015
Inflammatory profiles in canine intervertebral disc degeneration. BMC veterinary research\| PubMed ID: 26757881	2016
Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis research & therapy\| PubMed ID: 26939667	2016
Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration. European cells & materials\| PubMed ID: 27572543	2016
Bone Morphogenetic Protein-2, But Not Mesenchymal Stromal Cells, Exert Regenerative Effects on Canine and Human Nucleus Pulposus Cells. Tissue engineering. Part A\| PubMed ID: 27829314	2017
Lack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas. PloS one\| PubMed ID: 28005997	2016
Intradiscal application of a PCLA-PEG-PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines: What's in it for humans? Journal of tissue engineering and regenerative medicine\| PubMed ID: 28544701	2018
Growth plate expression profiling: Large and small breed dogs provide new insights in endochondral bone formation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 28681971	2018
The Myth of Fibroid Degeneration in the Canine Intervertebral Disc: A Histopathological Comparison of Intervertebral Disc Degeneration in Chondrodystrophic and Nonchondrodystrophic Dogs. Veterinary pathology\| PubMed ID: 28847244	2017
Phosphate Functional Groups Improve Oligo[(Polyethylene Glycol) Fumarate] Osteoconduction and BMP-2 Osteoinductive Efficacy. Tissue engineering. Part A\| PubMed ID: 29065776	2018
Link-N: The missing link towards intervertebral disc repair is species-specific. PloS one\| PubMed ID: 29117254	2017
Focal adhesion signaling affects regeneration by human nucleus pulposus cells in collagen- but not carbohydrate-based hydrogels. Acta biomaterialia\| PubMed ID: 29174589	2018
Comparing Hydrogels for Human Nucleus Pulposus Regeneration: Role of Osmolarity During Expansion. Tissue engineering. Part C, Methods\| PubMed ID: 29457534	2018
Bone morphogenetic protein-2 release profile modulates bone formation in phosphorylated hydrogel. Journal of tissue engineering and regenerative medicine\| PubMed ID: 29603878	2018
In Vitro and In Vivo Correlation of Bone Morphogenetic Protein-2 Release Profiles from Complex Delivery Vehicles. Tissue engineering. Part C, Methods\| PubMed ID: 29756545	2018
IL4-10 fusion protein has chondroprotective, anti-inflammatory and potentially analgesic effects in the treatment of osteoarthritis. Osteoarthritis and cartilage\| PubMed ID: 29775732	2018
Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside. Oncotarget\| PubMed ID: 29899873	2018
Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis. Journal of cellular physiology\| PubMed ID: 29932209	2018
Notochordal cell matrix: An inhibitor of neurite and blood vessel growth? Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 30035331	2018
The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent. Tissue engineering. Part A\| PubMed ID: 30101676	2019
Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 30110616	2018
Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced Bone Formation. Tissue engineering. Part A\| PubMed ID: 30612538	2019
Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems. Pharmaceutics\| PubMed ID: 30736430	2019
Sequential Treatment of a Large Pituitary Corticotroph Neoplasm and Associated Neurological Signs in a Dog. Journal of the American Animal Hospital Association\| PubMed ID: 30776261	2019
Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 31373395	2019
Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing. British journal of pharmacology\| PubMed ID: 31378925	2019
Instrumented cervical fusion in nine dogs with caudal cervical spondylomyelopathy. Veterinary surgery : VS\| PubMed ID: 31441092	2019
Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration. JOR spine\| PubMed ID: 31463463	2019
Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification. JOR spine\| PubMed ID: 31891120	2019
Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration. International journal of molecular sciences\| PubMed ID: 32295299	2020
Characterization of biomaterials intended for use in the nucleus pulposus of degenerated intervertebral discs. Acta biomaterialia\| PubMed ID: 32771592	2020
"Old Drugs, New Tricks" - Local controlled drug release systems for treatment of degenerative joint disease. Advanced drug delivery reviews\| PubMed ID: 33122086	2020
Transformed Canine and Murine Mesenchymal Stem Cells as a Model for Sarcoma with Complex Genomics. Cancers\| PubMed ID: 33807947	2021
Biomechanical effects of a titanium intervertebral cage as a stand-alone device, and in combination with locking plates in the canine caudal cervical spine. Veterinary surgery : VS\| PubMed ID: 33955033	2021
Enhanced Extracellular Matrix Breakdown Characterizes the Early Distraction Phase of Canine Knee Joint Distraction. Cartilage\| PubMed ID: 34014119	2021
Recognizing the ethical implications of stem cell research: A call for broadening the scope. Stem cell reports\| PubMed ID: 34214488	2021
A comprehensive tool box for large animal studies of intervertebral disc degeneration. JOR spine\| PubMed ID: 34337336	2021
A perspective on the initiative to develop a multi-species histopathology series. JOR spine\| PubMed ID: 34337339	2021
Selection of Highly Proliferative and Multipotent Meniscus Progenitors through Differential Adhesion to Fibronectin: A Novel Approach in Meniscus Tissue Engineering. International journal of molecular sciences\| PubMed ID: 34445320	2021
Prospective Evaluation of Local Sustained Release of Celecoxib in Dogs with Low Back Pain. Pharmaceutics\| PubMed ID: 34452138	2021
The genomic profiling and MAMLD1 expression in human and canines with Cushing's disease. BMC endocrine disorders\| PubMed ID: 34517852	2021
Sustained Intra-Articular Release and Biocompatibility of Tacrolimus (FK506) Loaded Monospheres Composed of [PDLA-PEG]--[PLLA] Multi-Block Copolymers in Healthy Horse Joints. Pharmaceutics\| PubMed ID: 34575514	2021
The function of CD146 in human annulus fibrosus cells and mechanism of the regulation by TGF-β. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 34662464	2022
A bovine nucleus pulposus explant culture model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 34812520	2022
Comparing Hip Dysplasia in Dogs and Humans: A Review. Frontiers in veterinary science\| PubMed ID: 34977223	2021
Cell sources proposed for nucleus pulposus regeneration. JOR spine\| PubMed ID: 35005441	2021
Patient-specific 3D-printed shelf implant for the treatment of hip dysplasia tested in an experimental animal pilot in canines. Scientific reports\| PubMed ID: 35194117	2022
Injectable Hydrogels for Articular Cartilage and Nucleus Pulposus Repair: Status Quo and Prospects. Tissue engineering. Part A\| PubMed ID: 35232245	2022
Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids. Cartilage\| PubMed ID: 35255727	2022
Intervertebral disc degeneration in warmblood horses: Histological and biochemical characterization. Veterinary pathology\| PubMed ID: 35291907	2022
Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration. Frontiers in cell and developmental biology\| PubMed ID: 35359916	2021
Roles and responsibilities in stem cell research: a focus group study with stem cell researchers and patients. Regenerative medicine\| PubMed ID: 35582744	2022
Detergent-Free Decellularization of Notochordal Cell-Derived Matrix Yields a Regenerative, Injectable, and Swellable Biomaterial. ACS biomaterials science & engineering\| PubMed ID: 35942885	2022
Intradiscal injection of human recombinant BMP-4 does not reverse intervertebral disc degeneration induced by nuclectomy in sheep. Journal of orthopaedic translation\| PubMed ID: 36196149	2022
Hyperosmolar expansion medium improves nucleus pulposus cell phenotype. JOR spine\| PubMed ID: 36203869	2022
Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients. Osteoarthritis and cartilage\| PubMed ID: 36473675	2023
Lack of concentration-dependent local toxicity of highly concentrated (5%) versus conventional 0.5% bupivacaine following musculoskeletal surgery in a rat model. Journal of experimental orthopaedics\| PubMed ID: 36884187	2023
Harmonization and standardization of nucleus pulposus cell extraction and culture methods. JOR spine\| PubMed ID: 36994456	2023
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue. JOR spine\| PubMed ID: 36994465	2023
Mechanical characterization of a novel biomimetic artificial disc for the cervical spine. Journal of the mechanical behavior of biomedical materials\| PubMed ID: 37087956	2023
Acetabular rim extension using a personalized titanium implant for treatment of hip dysplasia in dogs: short-term results. Frontiers in veterinary science\| PubMed ID: 37152693	2023
Biomechanical evaluation of a novel biomimetic artificial intervertebral disc in canine cervical cadaveric spines. JOR spine\| PubMed ID: 37361332	2023
A Combined Western and Bead-Based Multiplex Platform to Characterize Extracellular Vesicles. Tissue engineering. Part C, Methods\| PubMed ID: 37470213	2023
Semi-synthetic degradable notochordal cell-derived matrix hydrogel for use in degenerated intervertebral discs: Initial in vitro characterization. Journal of biomedical materials research. Part A\| PubMed ID: 37539663	2023
An insight on the -glycome of notochordal cell-rich porcine nucleus pulposus during maturation. FASEB bioAdvances\| PubMed ID: 37554546	2023
Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization. JOR spine\| PubMed ID: 37780826	2023
Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes. JOR spine\| PubMed ID: 37780831	2023
Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily. JOR spine\| PubMed ID: 38222814	2024
and models define a molecular signature reference for human embryonic notochordal cells. iScience\| PubMed ID: 38357665	2024
Automatic grading of intervertebral disc degeneration in lumbar dog spines. JOR spine\| PubMed ID: 38633660	2024