Erin E. Kershaw

Division of Endocrinology and Metabolism, University of Pittsburgh

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2024

Other Publications

Article	Year
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. The Journal of biological chemistry\| PubMed ID: 19723629	2009
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. Journal of lipid research\| PubMed ID: 21068004	2011
Transcriptional control of adipose lipid handling by IRF4. Cell metabolism\| PubMed ID: 21356515	2011
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nature medicine\| PubMed ID: 21857651	2011
Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Molecular and cellular biology\| PubMed ID: 22158969
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell metabolism\| PubMed ID: 22560221	2012
Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3). PloS one\| PubMed ID: 23115649	2012
Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling. Journal of lipid research\| PubMed ID: 23220585	2013
Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy. Diabetes\| PubMed ID: 23349479
Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation. Cardiovascular research\| PubMed ID: 23708736
Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes\| PubMed ID: 23835334	2013
Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation. Journal of lipid research\| PubMed ID: 25193997	2014
Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids. Journal of hepatology\| PubMed ID: 25733154	2015
Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 25783895	2015
Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 25865747	2015
Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis. Journal of leukocyte biology\| PubMed ID: 26109679	2015
Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice. Endocrinology\| PubMed ID: 26196542	2015
Adipose Tissue Lipolysis Promotes Exercise-induced Cardiac Hypertrophy Involving the Lipokine C16:1n7-Palmitoleate. The Journal of biological chemistry\| PubMed ID: 26260790	2015
Manganese [III] Tetrakis [5,10,15,20]-Benzoic Acid Porphyrin Reduces Adiposity and Improves Insulin Action in Mice with Pre-Existing Obesity. PloS one\| PubMed ID: 26397111	2015
Three-Dimensional Adipocyte Culture: The Next Frontier for Adipocyte Biology Discovery. Endocrinology\| PubMed ID: 26492473	2015
Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 26727116	2015
Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes. Oncotarget\| PubMed ID: 27105497	2016
A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nature genetics\| PubMed ID: 27455349	2016
Liver X receptor mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression. JCI insight\| PubMed ID: 28239648	2017
Autotaxin Is Regulated by Glucose and Insulin in Adipocytes. Endocrinology\| PubMed ID: 28324037	2017
Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids. Journal of lipid research\| PubMed ID: 28404638	2017
Differential Impact of Weight Loss on Nonalcoholic Fatty Liver Resolution in a North American Cohort with Obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 28605159	2017
Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner. JCI insight\| PubMed ID: 28814665	2017
Single-Step qPCR and dPCR Detection of Diverse CRISPR-Cas9 Gene Editing Events . G3 (Bethesda, Md.)\| PubMed ID: 28860183	2017
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Cell metabolism\| PubMed ID: 28877455	2017
Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue. Cell metabolism\| PubMed ID: 28988821	2017
Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure. PLoS genetics\| PubMed ID: 29320510	2018
Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation. Journal of lipid research\| PubMed ID: 29599420	2018
Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis. Science signaling\| PubMed ID: 29692363	2018
Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 29932770	2018
Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 30086648	2018
Wnt Pathway Inhibitor DKK1: A Potential Novel Biomarker for Adiposity. Journal of the Endocrine Society\| PubMed ID: 30746507	2019
Symptoms and Dietary Impact in Hypertriglyceridemia-Associated Pancreatitis: Development and Content Validity of Two New Measures. PharmacoEconomics - open\| PubMed ID: 31250380	2020
Impact of Hepatic Steatosis on Resting Metabolic Rate and Metabolic Adaptation in Response to Intentional Weight Loss. Hepatology communications\| PubMed ID: 31592493	2019
Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality. Nutrients\| PubMed ID: 31652734	2019
The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women. PloS one\| PubMed ID: 31770380	2019
Decreased Mitochondrial Dynamics Is Associated with Insulin Resistance, Metabolic Rate, and Fitness in African Americans. The Journal of clinical endocrinology and metabolism\| PubMed ID: 31833547	2020
Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation. The Journal of clinical investigation\| PubMed ID: 31917686	2020
Exploring the Paradoxical Relationship of a Creb 3 Regulatory Factor Missense Variant With Body Mass Index and Diabetes Among Samoans: Protocol for the Soifua Manuia (Good Health) Observatio... JMIR research protocols\| PubMed ID: 32706746	2020
Inhibition of ATGL in adipose tissue ameliorates isoproterenol-induced cardiac remodeling by reducing adipose tissue inflammation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 33185110	2021
Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase. Communications biology\| PubMed ID: 33692445	2021
Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 33957803	2021
Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage. Cardiovascular research\| PubMed ID: 34061169	2022
C-reactive protein in adult Samoans: Population variation and physiological correlates. American journal of human biology : the official journal of the Human Biology Council\| PubMed ID: 34260111	2022
Body size and composition of Samoan toddlers aged 18-25 months in 2019. Annals of human biology\| PubMed ID: 34340601	2021
A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress. PloS one\| PubMed ID: 34520472	2021
Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice. Acta pharmaceutica Sinica. B\| PubMed ID: 35024306	2021
Effect of physical activity in a weight loss program on circulating total ANGPTL8 concentrations in northern Americans with obesity: A prospective randomized controlled trial. Nutrition, metabolism, and cardiovascular diseases : NMCD\| PubMed ID: 35527126	2022
The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans. Obesity (Silver Spring, Md.)\| PubMed ID: 36284436	2022
A stop-gain variant in is associated with atherogenic lipid profiles. HGG advances\| PubMed ID: 36340932	2023
Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries. Genetic epidemiology\| PubMed ID: 36352773	2023
Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial. Nature medicine\| PubMed ID: 36879129	2023
Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. bioRxiv : the preprint server for biology\| PubMed ID: 37214953	2023
Medical management of hypertriglyceridemia in pancreatitis. Current opinion in gastroenterology\| PubMed ID: 37421386	2023
Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. Journal of lipid research\| PubMed ID: 37640283	2024
Association between age at menarche and cardiometabolic risk among Samoan adults. American journal of human biology : the official journal of the Human Biology Council\| PubMed ID: 37668413	2024
Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA). GeroScience\| PubMed ID: 38315316	2024
Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes. Diabetes\| PubMed ID: 38551899	2024

Article	Year
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. The Journal of biological chemistry\| PubMed ID: 19723629	2009
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. Journal of lipid research\| PubMed ID: 21068004	2011
Transcriptional control of adipose lipid handling by IRF4. Cell metabolism\| PubMed ID: 21356515	2011
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nature medicine\| PubMed ID: 21857651	2011
Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Molecular and cellular biology\| PubMed ID: 22158969
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell metabolism\| PubMed ID: 22560221	2012
Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3). PloS one\| PubMed ID: 23115649	2012
Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling. Journal of lipid research\| PubMed ID: 23220585	2013
Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy. Diabetes\| PubMed ID: 23349479
Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation. Cardiovascular research\| PubMed ID: 23708736
Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes\| PubMed ID: 23835334	2013
Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation. Journal of lipid research\| PubMed ID: 25193997	2014
Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids. Journal of hepatology\| PubMed ID: 25733154	2015
Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 25783895	2015
Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 25865747	2015
Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis. Journal of leukocyte biology\| PubMed ID: 26109679	2015
Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice. Endocrinology\| PubMed ID: 26196542	2015
Adipose Tissue Lipolysis Promotes Exercise-induced Cardiac Hypertrophy Involving the Lipokine C16:1n7-Palmitoleate. The Journal of biological chemistry\| PubMed ID: 26260790	2015
Manganese [III] Tetrakis [5,10,15,20]-Benzoic Acid Porphyrin Reduces Adiposity and Improves Insulin Action in Mice with Pre-Existing Obesity. PloS one\| PubMed ID: 26397111	2015
Three-Dimensional Adipocyte Culture: The Next Frontier for Adipocyte Biology Discovery. Endocrinology\| PubMed ID: 26492473	2015
Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 26727116	2015
Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes. Oncotarget\| PubMed ID: 27105497	2016
A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nature genetics\| PubMed ID: 27455349	2016
Liver X receptor mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression. JCI insight\| PubMed ID: 28239648	2017
Autotaxin Is Regulated by Glucose and Insulin in Adipocytes. Endocrinology\| PubMed ID: 28324037	2017
Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids. Journal of lipid research\| PubMed ID: 28404638	2017
Differential Impact of Weight Loss on Nonalcoholic Fatty Liver Resolution in a North American Cohort with Obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 28605159	2017
Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner. JCI insight\| PubMed ID: 28814665	2017
Single-Step qPCR and dPCR Detection of Diverse CRISPR-Cas9 Gene Editing Events . G3 (Bethesda, Md.)\| PubMed ID: 28860183	2017
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Cell metabolism\| PubMed ID: 28877455	2017
Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue. Cell metabolism\| PubMed ID: 28988821	2017
Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure. PLoS genetics\| PubMed ID: 29320510	2018
Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation. Journal of lipid research\| PubMed ID: 29599420	2018
Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis. Science signaling\| PubMed ID: 29692363	2018
Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 29932770	2018
Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 30086648	2018
Wnt Pathway Inhibitor DKK1: A Potential Novel Biomarker for Adiposity. Journal of the Endocrine Society\| PubMed ID: 30746507	2019
Symptoms and Dietary Impact in Hypertriglyceridemia-Associated Pancreatitis: Development and Content Validity of Two New Measures. PharmacoEconomics - open\| PubMed ID: 31250380	2020
Impact of Hepatic Steatosis on Resting Metabolic Rate and Metabolic Adaptation in Response to Intentional Weight Loss. Hepatology communications\| PubMed ID: 31592493	2019
Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality. Nutrients\| PubMed ID: 31652734	2019
The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women. PloS one\| PubMed ID: 31770380	2019
Decreased Mitochondrial Dynamics Is Associated with Insulin Resistance, Metabolic Rate, and Fitness in African Americans. The Journal of clinical endocrinology and metabolism\| PubMed ID: 31833547	2020
Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation. The Journal of clinical investigation\| PubMed ID: 31917686	2020
Exploring the Paradoxical Relationship of a Creb 3 Regulatory Factor Missense Variant With Body Mass Index and Diabetes Among Samoans: Protocol for the Soifua Manuia (Good Health) Observatio... JMIR research protocols\| PubMed ID: 32706746	2020
Inhibition of ATGL in adipose tissue ameliorates isoproterenol-induced cardiac remodeling by reducing adipose tissue inflammation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 33185110	2021
Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase. Communications biology\| PubMed ID: 33692445	2021
Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 33957803	2021
Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage. Cardiovascular research\| PubMed ID: 34061169	2022
C-reactive protein in adult Samoans: Population variation and physiological correlates. American journal of human biology : the official journal of the Human Biology Council\| PubMed ID: 34260111	2022
Body size and composition of Samoan toddlers aged 18-25 months in 2019. Annals of human biology\| PubMed ID: 34340601	2021
A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress. PloS one\| PubMed ID: 34520472	2021
Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice. Acta pharmaceutica Sinica. B\| PubMed ID: 35024306	2021
Effect of physical activity in a weight loss program on circulating total ANGPTL8 concentrations in northern Americans with obesity: A prospective randomized controlled trial. Nutrition, metabolism, and cardiovascular diseases : NMCD\| PubMed ID: 35527126	2022
The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans. Obesity (Silver Spring, Md.)\| PubMed ID: 36284436	2022
A stop-gain variant in is associated with atherogenic lipid profiles. HGG advances\| PubMed ID: 36340932	2023
Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries. Genetic epidemiology\| PubMed ID: 36352773	2023
Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial. Nature medicine\| PubMed ID: 36879129	2023
Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. bioRxiv : the preprint server for biology\| PubMed ID: 37214953	2023
Medical management of hypertriglyceridemia in pancreatitis. Current opinion in gastroenterology\| PubMed ID: 37421386	2023
Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. Journal of lipid research\| PubMed ID: 37640283	2024
Association between age at menarche and cardiometabolic risk among Samoan adults. American journal of human biology : the official journal of the Human Biology Council\| PubMed ID: 37668413	2024
Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA). GeroScience\| PubMed ID: 38315316	2024
Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes. Diabetes\| PubMed ID: 38551899	2024