isolation-and-culture-of-primary-human-mammary-epithelial-cells

Isolation and Culture of Primary Human Mammary Epithelial Cells

The mammary gland is a fundamental structure of the breast and plays an essential role in reproduction. Human mammary epithelial cells (HMECs), which are ...

a-simplified-robust-protocol-for-isolation-long-term-expansion

A Simplified and Robust Protocol for the Isolation and Long-term Expansion of Primary Human Endometrial Epithelial Cells

Research on endometrial disorders, including tamoxifen-associated endometrial hyperplasia, has been limited by the lack of robust in vitro epithelial ...

The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)

Bozhou District Hospital of Traditional Chinese Medicine

The Affiliated Traditional Chinese Medicine Hospital of Shihezi University

Mitogen-activated protein kinase phosphatases (MKPs), also known as dual-specificity phosphatases (DUSPs), are key regulatory factors within the mitogen-activated protein kinase (MAPK) pathway. MKP7/DUSP16, a member of the MKP family, has been identified in vitro as a phosphatase with specificity for p38 mitogen-activated protein kinase (p38) and c-jun amino-terminal kinase (JNK), with a stronger inhibitory effect on JNK compared to other MAPKs. In recent years, MKP7/DUSP16 has recently attracted increasing interest, with accumulating evidence suggesting its dysfunction is correlated with the progression and drug resistance of various cancers, making it a potential prognostic biomarker. However, research into the specific mechanisms by which MKP7/DUSP16 regulates cancer cells remains limited. Current studies suggest that MKP7/DUSP16 may promote cancer progression through the regulation of the MAPK pathway, mitochondrial apoptosis pathways, and the induction of cancer cell proliferation by immune cells. This review summarizes the mechanisms by which MKP7/DUSP16 may promote tumor proliferation. Further studies are needed to clarify its specific regulatory roles in cancer.

ArticleTotal : 2	Year
Publication title	2024
Publication title	2026

Xiaohong Xu

Biography

JoVE Journal Publications

Other Publications