David J. Marcinek

Department of Radiology, University of Washington

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Basal glycogenolysis in mouse skeletal muscle: in vitro model predicts in vivo fluxes. Molecular biology reports\| PubMed ID: 12241044	2002
Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12775561	2003
Mitochondrial coupling in vivo in mouse skeletal muscle. American journal of physiology. Cell physiology\| PubMed ID: 14522819	2004
Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle. The Journal of physiology\| PubMed ID: 16254011	2005
Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo. Experimental physiology\| PubMed ID: 17170059	2007
Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17215370	2007
Mitochondrial dysfunction: impact on exercise performance and cellular aging. Exercise and sport sciences reviews\| PubMed ID: 17417049	2007
Wavelength shift analysis: a simple method to determine the contribution of hemoglobin and myoglobin to in vivo optical spectra. Applied spectroscopy\| PubMed ID: 17650380	2007
Mitochondrial dysfunction and age. Current opinion in clinical nutrition and metabolic care\| PubMed ID: 18089948	2007
Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Cell metabolism\| PubMed ID: 18396137	2008
Mitochondrial function in vivo: spectroscopy provides window on cellular energetics. Methods (San Diego, Calif.)\| PubMed ID: 18930151	2008
Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 20133437	2010
Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging cell\| PubMed ID: 20456298	2010
Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circulation research\| PubMed ID: 21311045	2011
Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice. PloS one\| PubMed ID: 22132085	2011
A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity. PloS one\| PubMed ID: 22567140	2012
Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle. Mechanisms of ageing and development\| PubMed ID: 22935551	2012
Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition. Human molecular genetics\| PubMed ID: 23049075	2013
Higher mitochondrial respiration and uncoupling with reduced electron transport chain content in vivo in muscle of sedentary versus active subjects. The Journal of clinical endocrinology and metabolism\| PubMed ID: 23150693	2013
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Aging cell\| PubMed ID: 23692570	2013
Targeting redox biology to reverse mitochondrial dysfunction. Aging\| PubMed ID: 23945201	2013
Mitochondrial oxidative stress in aging and healthspan. Longevity & healthspan\| PubMed ID: 24860647	2014
Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Aquatic toxicology (Amsterdam, Netherlands)\| PubMed ID: 25033243	2014
In vivo metabolic spectroscopy identifies deficits in mitochondrial quality and capacity in aging skeletal muscle. Clinical pharmacology and therapeutics\| PubMed ID: 25207702	2014
Effect of omega-3 fatty acid oxidation products on the cellular and mitochondrial toxicity of BDE 47. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 25659769	2015
Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 26494550	2016
Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging cell\| PubMed ID: 26498839	2016
The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function. Frontiers in physiology\| PubMed ID: 26635632	2015
Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods. Biochimica et biophysica acta\| PubMed ID: 26708941	2016
Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms. Antioxidants & redox signaling\| PubMed ID: 27393340	2017
NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Science translational medicine\| PubMed ID: 27798264	2016
Skeletal muscle bioenergetics in aging and heart failure. Heart failure reviews\| PubMed ID: 27815651	2017
The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney international\| PubMed ID: 28063595	2017
Acute and chronic dietary exposure to domoic acid in recreational harvesters: A survey of shellfish consumption behavior. Environment international\| PubMed ID: 28109640	2017
Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28130547	2017
Chronic low-level exposure to the common seafood toxin domoic acid causes cognitive deficits in mice. Harmful algae\| PubMed ID: 28427569	2017
Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon. Aquatic toxicology (Amsterdam, Netherlands)\| PubMed ID: 28668760	2017
Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects. PloS one\| PubMed ID: 28700655	2017
Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox biology\| PubMed ID: 29857311	2018
Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 30259703	2018
Domoic acid in California sea lion fetal fluids indicates continuous exposure to a neuroteratogen poses risks to mammals. Harmful algae\| PubMed ID: 30420016	2018
Repeated low level domoic acid exposure increases CA1 VGluT1 levels, but not bouton density, VGluT2 or VGAT levels in the hippocampus of adult mice. Harmful algae\| PubMed ID: 30420019	2018
Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free radical biology & medicine\| PubMed ID: 30597195	2019
Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor. Toxins\| PubMed ID: 31126088	2019
Mitochondrial protein interaction landscape of SS-31. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32554501	2020
SS-31 and NMN: Two paths to improve metabolism and function in aged hearts. Aging cell\| PubMed ID: 32779818	2020
Increased tumour burden alters skeletal muscle properties in the KPC mouse model of pancreatic cancer. JCSM rapid communications\| PubMed ID: 33073264	2020
Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte. eLife\| PubMed ID: 33319746	2020
High intensity muscle stimulation activates a systemic Nrf2-mediated redox stress response. Free radical biology & medicine\| PubMed ID: 34089788	2021
Are fat and sugar just as detrimental in old age? GeroScience\| PubMed ID: 34101101	2021
Astaxanthin supplementation enhances metabolic adaptation with aerobic training in the elderly. Physiological reports\| PubMed ID: 34110707	2021
In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial. PloS one\| PubMed ID: 34264994	2021
Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins. GeroScience\| PubMed ID: 34480713	2021
A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA. Nucleic acids research\| PubMed ID: 34614167	2021
Ice seals as sentinels for algal toxin presence in the Pacific Arctic and subarctic marine ecosystems. Marine Mammal Science\| PubMed ID: 34690417	2021
An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice. Investigative ophthalmology & visual science\| PubMed ID: 34797906	2021
Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA network open\| PubMed ID: 35050355	2022
Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice. Aging pathobiology and therapeutics\| PubMed ID: 36250163	2022
Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice. GeroScience\| PubMed ID: 36322234	2022
Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption. Nutrients\| PubMed ID: 36364920	2022
Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 36462195	2023
dATP elevation induces myocardial metabolic remodeling to support improved cardiac function. Journal of molecular and cellular cardiology\| PubMed ID: 36470336	2023
The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 36754371	2023
Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT). bioRxiv : the preprint server for biology\| PubMed ID: 36778398	2023
The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging. eLife\| PubMed ID: 36799304	2023
From mitochondria to cells to humans: Targeting bioenergetics in aging and disease. The international journal of biochemistry & cell biology\| PubMed ID: 36806357	2023
ATP and NAD Deficiency in Parkinson's Disease. Nutrients\| PubMed ID: 36839301	2023
Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice. GeroScience\| PubMed ID: 36840897	2023
Age and Sex as Determinants of Acute Domoic Acid Toxicity in a Mouse Model. Toxins\| PubMed ID: 37104198	2023
Skeletal muscle mitochondrial interactome remodeling is linked to functional decline in aged female mice. Nature aging\| PubMed ID: 37118428	2023
Randomized crossover clinical trial of coenzyme Q10 and nicotinamide riboside in chronic kidney disease. JCI insight\| PubMed ID: 37159264	2023
A novel mitochondrial complex I ROS inhibitor partially improves muscle regeneration in adult but not old mice. Redox biology\| PubMed ID: 37295159	2023
The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT). GeroScience\| PubMed ID: 37462785	2023
Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent. The Journal of physiology\| PubMed ID: 37742081	2023
Mitochondrial Targeted Interventions for Aging. Cold Spring Harbor perspectives in medicine\| PubMed ID: 37788882	2024
Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Agi... medRxiv : the preprint server for health sciences\| PubMed ID: 37986748	2023
Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging. GeroScience\| PubMed ID: 37987886	2024
Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 38150179	2024
Energetics and clinical factors for the time required to walk 400 m: The Study of Muscle, Mobility and Aging (SOMMA). Journal of the American Geriatrics Society\| PubMed ID: 38243364	2024
Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Agi... Aging cell\| PubMed ID: 38332629	2024
Childhood adverse life events and skeletal muscle mitochondrial function. Science advances\| PubMed ID: 38446898	2024
Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes. Diabetes\| PubMed ID: 38551899	2024
Older-aged C57BL/6 mice fed a diet high in saturated fat and sucrose for ten months show decreased resilience to aging. Aging pathobiology and therapeutics\| PubMed ID: 38706773	2023