Maria S. Remedi

Department of Medicine, Washington University School of Medicine

Affiliated withWashington University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2024

Other Publications

Article	Year
HIV protease inhibitors acutely impair glucose-stimulated insulin release. Diabetes\| PubMed ID: 12829635	2003
Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 14656703	2004
Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. Diabetes\| PubMed ID: 15561916	2004
Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels. Diabetes\| PubMed ID: 15561946	2004
Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP). Journal of molecular and cellular cardiology\| PubMed ID: 16099470	2005
ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy. Diabetes\| PubMed ID: 16123353	2005
ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes. Diabetes\| PubMed ID: 16186394	2005
Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets. The Journal of biological chemistry\| PubMed ID: 16344552	2006
Critical role of gap junction coupled KATP channel activity for regulated insulin secretion. PLoS biology\| PubMed ID: 16402858	2006
Hyperinsulinism in mice with heterozygous loss of K(ATP) channels. Diabetologia\| PubMed ID: 16924481	2006
Expression of ATP-insensitive KATP channels in pancreatic beta-cells underlies a spectrum of diabetic phenotypes. Diabetes\| PubMed ID: 17065331	2006
Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells. PLoS medicine\| PubMed ID: 18959471	2008
Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy. Circulation research\| PubMed ID: 19023131	2009
Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. Cell metabolism\| PubMed ID: 19187772	2009
K(ATP) channelopathies in the pancreas. Pflugers Archiv : European journal of physiology\| PubMed ID: 19921246	2010
Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice. Cell metabolism\| PubMed ID: 19945402	2009
HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels. Journal of molecular and cellular cardiology\| PubMed ID: 21185839	2011
Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes. Diabetes\| PubMed ID: 21813803	2011
Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle. Journal of the American Heart Association\| PubMed ID: 23974906	2013
Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell metabolism\| PubMed ID: 24746806	2014
Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell reports\| PubMed ID: 24910426	2014
Remission of severe neonatal diabetes with very early sulfonylurea treatment. Diabetes care\| PubMed ID: 25715421	2015
Pancreatic β-cell identity in diabetes. Diabetes, obesity & metabolism\| PubMed ID: 27615139	2016
An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion. Molecular metabolism\| PubMed ID: 27656398	2016
Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. The Journal of clinical investigation\| PubMed ID: 27820699	2016
Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel. The Journal of general physiology\| PubMed ID: 27956473	2017
Should I Stay or Should I Go: A Clash of α-Cell Identity. Cell metabolism\| PubMed ID: 28273469	2017
Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Autophagy\| PubMed ID: 28853981	2017
High-fat-diet-induced remission of diabetes in a subset of K -GOF insulin-secretory-deficient mice. Diabetes, obesity & metabolism\| PubMed ID: 29896801	2018
Cardiovascular consequences of KATP overactivity in Cantu syndrome. JCI insight\| PubMed ID: 30089727	2018
In vivo monitoring of intracellular Ca dynamics in the pancreatic β-cells of zebrafish embryos. Islets\| PubMed ID: 30521410	2018
The role of membrane excitability in pancreatic β-cell glucotoxicity. Scientific reports\| PubMed ID: 31061431	2019
ABCC9-related Intellectual disability Myopathy Syndrome is a K channelopathy with loss-of-function mutations in ABCC9. Nature communications\| PubMed ID: 31575858	2019
Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity. The Journal of clinical investigation\| PubMed ID: 31821173	2020
Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry. American journal of medical genetics. Part C, Seminars in medical genetics\| PubMed ID: 31828977	2019
Kir6.1-dependent K channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain-of-function. The Journal of physiology\| PubMed ID: 32372450	2020
Alterations in pancreatic islet cell function in response to small bowel resection. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 32463335	2020
The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome. Function (Oxford, England)\| PubMed ID: 32865539	2020
Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome. JCI insight\| PubMed ID: 33170808	2020
Preferential Gq signaling in diabetes: an electrical switch in incretin action and in diabetes progression? The Journal of clinical investigation\| PubMed ID: 33196460	2020
Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice. JCI insight\| PubMed ID: 33529173	2021
Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 33831261	2021
Cognitive deficits and impaired hippocampal long-term potentiation in K-induced DEND syndrome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34732576	2021
ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm? Diabetes\| PubMed ID: 35196393	2022
Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in KATP-Induced Neonatal Diabetes. Diabetes\| PubMed ID: 35294000	2022
A Unique High-Output Cardiac Hypertrophy Phenotype Arising From Low Systemic Vascular Resistance in Cantu Syndrome. Journal of the American Heart Association\| PubMed ID: 36515236	2022
Glucokinase Inhibition: A Novel Treatment for Diabetes? Diabetes\| PubMed ID: 36669001	2023
KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer's disease-related pathology. JCI insight\| PubMed ID: 37129980	2023
Intermittent fasting protects β-cell identity and function in a type-2 diabetes model. Metabolism: clinical and experimental\| PubMed ID: 38307325	2024