Carlos B. Mantilla

Department of Physiology and Biomedical Engineering, Mayo Clinic

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 5	2024
Publication title	2025

Other Publications

Article	Year
Frequency of myocardial infarction, pulmonary embolism, deep venous thrombosis, and death following primary hip or knee arthroplasty. Anesthesiology\| PubMed ID: 11981154	2002
Denervation-induced changes in myosin heavy chain expression in the rat diaphragm muscle. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 12704093	2003
Risk factors for clinically relevant pulmonary embolism and deep venous thrombosis in patients undergoing primary hip or knee arthroplasty. Anesthesiology\| PubMed ID: 12960538	2003
The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells. Endocrinology\| PubMed ID: 14563702	2004
Regulation of neuromuscular transmission by neurotrophins. Sheng li xue bao : [Acta physiologica Sinica]\| PubMed ID: 14695476	2003
Neurotrophins improve neuromuscular transmission in the adult rat diaphragm. Muscle & nerve\| PubMed ID: 14981737	2004
Effect of neurolytic celiac plexus block on pain relief, quality of life, and survival in patients with unresectable pancreatic cancer: a randomized controlled trial. JAMA\| PubMed ID: 14996778	2004
Synaptic vesicle cycling at type-identified diaphragm neuromuscular junctions. Muscle & nerve\| PubMed ID: 15478121	2004
Respiratory muscle plasticity. Respiratory physiology & neurobiology\| PubMed ID: 15871925	2005
Differential inhibition of neuronal Na+-Ca2+ exchange versus store-operated Ca2+ channels by volatile anesthetics in pheochromocytoma (PC12) cells. Anesthesiology\| PubMed ID: 15983461	2005
Denervation effects on myonuclear domain size of rat diaphragm fibers. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 16410375	2006
Optimizing conditions and avoiding pitfalls for prolonged axonal tracing with carbocyanine dyes in fixed rat spinal cords. Journal of neuroscience methods\| PubMed ID: 16466800	2006
Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 16648236	2006
Neuregulin-dependent protein synthesis in C2C12 myotubes and rat diaphragm muscle. American journal of physiology. Cell physiology\| PubMed ID: 16790500	2006
Mechanisms underlying myosin heavy chain expression during development of the rat diaphragm muscle. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 16873604	2006
Safety factor for neuromuscular transmission at type-identified diaphragm fibers. Muscle & nerve\| PubMed ID: 17286272	2007
Synaptic vesicle distribution and release at rat diaphragm neuromuscular junctions. Journal of neurophysiology\| PubMed ID: 17493926	2007
EMG-based detection of inspiration in the rat diaphragm muscle. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 17946030	2006
Developmental effects on myonuclear domain size of rat diaphragm fibers. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 18187618	2008
Key aspects of phrenic motoneuron and diaphragm muscle development during the perinatal period. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 18403452	2008
Trophic factor expression in phrenic motor neurons. Respiratory physiology & neurobiology\| PubMed ID: 18708170	2008
The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19520837	2009
Retrograde labeling of phrenic motoneurons by intrapleural injection. Journal of neuroscience methods\| PubMed ID: 19559048	2009
Novel method for physiological recruitment of diaphragm motor units after upper cervical spinal cord injury. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19628723	2009
Role of neurotrophins in recovery of phrenic motor function following spinal cord injury. Respiratory physiology & neurobiology\| PubMed ID: 19703592	2009
Neuromuscular adaptations to respiratory muscle inactivity. Respiratory physiology & neurobiology\| PubMed ID: 19744580	2009
Intrathecal Hydromorphone and Morphine for Postcesarean Delivery Analgesia: Determination of the ED90 Using a Sequential Allocation Biased-Coin Method. Anesthesia and analgesia\| PubMed ID: 26974022	2016
Diaphragm muscle sarcopenia in Fischer 344 and Brown Norway rats. Experimental physiology\| PubMed ID: 27126607	2016
Correlation of respiratory activity of contralateral diaphragm muscles for evaluation of recovery following hemiparesis. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference\| PubMed ID: 19965125	2009
Impairment of diaphragm muscle force and neuromuscular transmission after normothermic cardiopulmonary bypass: effect of low-dose inhaled CO. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 20089713	2010
Neurotrophins in lung health and disease. Expert review of respiratory medicine\| PubMed ID: 20524922	2010
Diaphragm motor unit recruitment in rats. Respiratory physiology & neurobiology\| PubMed ID: 20620243	2010
Associations between heat pain perception and pain severity among patients with chronic pain. Pain medicine (Malden, Mass.)\| PubMed ID: 20807344	2010
Smoking and pain: pathophysiology and clinical implications. Anesthesiology\| PubMed ID: 20864835	2010
Neuregulin-1 at synapses on phrenic motoneurons. The Journal of comparative neurology\| PubMed ID: 20878784	2010
Associations between heat pain perception and opioid dose among patients with chronic pain undergoing opioid tapering. Pain medicine (Malden, Mass.)\| PubMed ID: 21029354	2010
Intracellular signaling pathways regulating net protein balance following diaphragm muscle denervation. American journal of physiology. Cell physiology\| PubMed ID: 21084642	2011
Risk for perioperative myocardial infarction and mortality in patients undergoing hip or knee arthroplasty: the role of anemia. Transfusion\| PubMed ID: 21219324	2011
Perioperative nerve injury after total knee arthroplasty: regional anesthesia risk during a 20-year cohort study. Anesthesiology\| PubMed ID: 21239974	2011
Chronic assessment of diaphragm muscle EMG activity across motor behaviors. Respiratory physiology & neurobiology\| PubMed ID: 21414423	2011
Smoking and chronic pain: a real-but-puzzling relationship. Minnesota medicine\| PubMed ID: 21485923	2011
Preoperative gabapentin for acute post-thoracotomy analgesia: a randomized, double-blinded, active placebo-controlled study. Pain practice : the official journal of World Institute of Pain\| PubMed ID: 21676165	2012
Phrenic motor unit recruitment during ventilatory and non-ventilatory behaviors. Respiratory physiology & neurobiology\| PubMed ID: 21763470	2011
Perioperative nerve injury after total hip arthroplasty: regional anesthesia risk during a 20-year cohort study. Anesthesiology\| PubMed ID: 21934486	2011
Structure-activity relationships in rodent diaphragm muscle fibers vs. neuromuscular junctions. Respiratory physiology & neurobiology\| PubMed ID: 22063925	2012
Inhaled carbon monoxide attenuates myocardial inflammatory cytokine expression in a rat model of cardiopulmonary bypass. The Journal of extra-corporeal technology\| PubMed ID: 22164452	2011
Phrenic motoneuron expression of serotonergic and glutamatergic receptors following upper cervical spinal cord injury. Experimental neurology\| PubMed ID: 22227062	2012
The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. Muscle & nerve\| PubMed ID: 22246885	2012
Determination of the particulate size and aggregation of clonidine and corticosteroids for epidural steroid injection. Pain physician\| PubMed ID: 22270741	2012
Chronic postthoracotomy pain and health-related quality of life. The Annals of thoracic surgery\| PubMed ID: 22397986	2012
Reduced ribosomal protein s6 phosphorylation after progressive resistance exercise in growing adolescent rats. Journal of strength and conditioning research\| PubMed ID: 22614147	2012
Perioperative nerve injury after total shoulder arthroplasty: assessment of risk after regional anesthesia. Regional anesthesia and pain medicine\| PubMed ID: 22705952	2012
Systems biology of skeletal muscle: fiber type as an organizing principle. Wiley interdisciplinary reviews. Systems biology and medicine\| PubMed ID: 22811254	2012
Non-stationarity and power spectral shifts in EMG activity reflect motor unit recruitment in rat diaphragm muscle. Respiratory physiology & neurobiology\| PubMed ID: 22986086	2013
Nonalcoholic steatohepatitis in bariatric patients with a diagnosis of obstructive sleep apnea. Obesity facts\| PubMed ID: 22986647	2012
Have bilateral total knee arthroplasties become safer? A population-based trend analysis. Clinical orthopaedics and related research\| PubMed ID: 23008025	2013
Prolonged C2 spinal hemisection-induced inactivity reduces diaphragm muscle specific force with modest, selective atrophy of type IIx and/or IIb fibers. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 23195635	2013
Dual-Epidural Catheter Technique and Perioperative Outcomes After Ivor-Lewis Esophagectomy. Regional anesthesia and pain medicine\| PubMed ID: 23222360	2012
Neuromotor control in chronic obstructive pulmonary disease. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 23329816	2013
Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury. Experimental neurology\| PubMed ID: 23583688	2013
Novel method for transdiaphragmatic pressure measurements in mice. Respiratory physiology & neurobiology\| PubMed ID: 23632282	2013
Targeted delivery of TrkB receptor to phrenic motoneurons enhances functional recovery of rhythmic phrenic activity after cervical spinal hemisection. PloS one\| PubMed ID: 23724091	2013
Diaphragm muscle sarcopenia in aging mice. Experimental gerontology\| PubMed ID: 23792145	2013
Respiratory muscle plasticity. Comprehensive Physiology\| PubMed ID: 23798306	2012
Impact of diaphragm muscle fiber atrophy on neuromotor control. Respiratory physiology & neurobiology\| PubMed ID: 23831121	2013
Rebuttal from Gary C. Sieck and Carlos B. Mantilla. The Journal of physiology\| PubMed ID: 24187076	2013
Mechanical properties of respiratory muscles. Comprehensive Physiology\| PubMed ID: 24265238	2013
Convergence of pattern generator outputs on a common mechanism of diaphragm motor unit recruitment. Progress in brain research\| PubMed ID: 24746055	2014
TrkB kinase activity is critical for recovery of respiratory function after cervical spinal cord hemisection. Experimental neurology\| PubMed ID: 24910201	2014
Localized delivery of brain-derived neurotrophic factor-expressing mesenchymal stem cells enhances functional recovery following cervical spinal cord injury. Journal of neurotrauma\| PubMed ID: 25093762	2015
TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 25170066	2014
Recruitment of rat diaphragm motor units across motor behaviors with different levels of diaphragm activation. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 25257864	2014
Ageing and neurotrophic signalling effects on diaphragm neuromuscular function. The Journal of physiology\| PubMed ID: 25630263	2015
Impact of unilateral denervation on transdiaphragmatic pressure. Respiratory physiology & neurobiology\| PubMed ID: 25641347	2015
Analysis of muscle fiber clustering in the diaphragm muscle of sarcopenic mice. Muscle & nerve\| PubMed ID: 25808550	2015
Functional impact of diaphragm muscle sarcopenia in both male and female mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 25934669	2015
Semi-automated assessment of transdiaphragmatic pressure variability across motor behaviors. Respiratory physiology & neurobiology\| PubMed ID: 26003850	2015
The Impact of Midcervical Contusion Injury on Diaphragm Muscle Function. Journal of neurotrauma\| PubMed ID: 26413840	2016
Functional impact of sarcopenia in respiratory muscles. Respiratory physiology & neurobiology\| PubMed ID: 26467183	2016
Functional recovery after cervical spinal cord injury: Role of neurotrophin and glutamatergic signaling in phrenic motoneurons. Respiratory physiology & neurobiology\| PubMed ID: 26506253	2016
Role of TrkB kinase activity in aging diaphragm neuromuscular junctions. Experimental gerontology\| PubMed ID: 26517952	2015
TrkB gene therapy by adeno-associated virus enhances recovery after cervical spinal cord injury. Experimental neurology\| PubMed ID: 26607912	2016
Aging-related changes in respiratory system mechanics and morphometry in mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 27288490	2016
Increased Risk of Postthoracotomy Pain Syndrome in Patients with Prolonged Hospitalization and Increased Postoperative Opioid Use. Pain research and treatment\| PubMed ID: 27340565	2016
Functional Measurement of Respiratory Muscle Motor Behaviors Using Transdiaphragmatic Pressure. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27492181	2016
A novel approach for targeted delivery to motoneurons using cholera toxin-B modified protocells. Journal of neuroscience methods\| PubMed ID: 27641118	2016
Motoneuron glutamatergic receptor expression following recovery from cervical spinal hemisection. The Journal of comparative neurology\| PubMed ID: 27650492	2017
Gene therapy and respiratory neuroplasticity. Experimental neurology\| PubMed ID: 27697480	2017
Perioperative Nerve Injury After Peripheral Nerve Block in Patients With Previous Systemic Chemotherapy. Regional anesthesia and pain medicine\| PubMed ID: 27753708	2016
BDNF effects on functional recovery across motor behaviors after cervical spinal cord injury. Journal of neurophysiology\| PubMed ID: 27832605	2017
Diaphragm electromyographic activity following unilateral midcervical contusion injury in rats. Journal of neurophysiology\| PubMed ID: 27832610	2017
Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction. Physiological reports\| PubMed ID: 28082429	2017
A Three-arm Randomized Clinical Trial Comparing Continuous Femoral Plus Single-injection Sciatic Peripheral Nerve Blocks versus Periarticular Injection with Ropivacaine or Liposomal Bupivaca... Anesthesiology\| PubMed ID: 28234636	2017
Impact of glutamatergic and serotonergic neurotransmission on diaphragm muscle activity after cervical spinal hemisection. Journal of neurophysiology\| PubMed ID: 28659464	2017
Compensatory effects following unilateral diaphragm paralysis. Respiratory physiology & neurobiology\| PubMed ID: 28790008	2017
Continuous Posterior Lumbar Plexus Nerve Block Versus Periarticular Injection with Ropivacaine or Liposomal Bupivacaine for Total Hip Arthroplasty: A Three-Arm Randomized Clinical Trial. The Journal of bone and joint surgery. American volume\| PubMed ID: 29088038	2017
Uptake and intracellular fate of cholera toxin subunit b-modified mesoporous silica nanoparticle-supported lipid bilayers (aka protocells) in motoneurons. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 29339186	2018
Diaphragm muscle activity across respiratory motor behaviors in awake and lightly anesthetized rats. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 29357493	2018
Breathing: Motor Control of Diaphragm Muscle. Physiology (Bethesda, Md.)\| PubMed ID: 29412056	2018
Phrenic motor neuron loss in aged rats. Journal of neurophysiology\| PubMed ID: 29412773	2018
Impaired Autophagy in Motor Neurons: A Final Common Mechanism of Injury and Death. Physiology (Bethesda, Md.)\| PubMed ID: 29638184	2018
Impact of aging on diaphragm muscle function in male and female Fischer 344 rats. Physiological reports\| PubMed ID: 29981218	2018
Diaphragm muscle function following midcervical contusion injury in rats. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 30236045	2019
Impact of Frailty on Outcomes After Primary and Revision Total Hip Arthroplasty. The Journal of arthroplasty\| PubMed ID: 30340916	2019
Phrenic motoneuron structural plasticity across models of diaphragm muscle paralysis. The Journal of comparative neurology\| PubMed ID: 30411341	2018
Frequency-dependent lipid raft uptake at rat diaphragm muscle axon terminals. Muscle & nerve\| PubMed ID: 30677149	2019
Impact of sarcopenia on diaphragm muscle fatigue. Experimental physiology\| PubMed ID: 30924589	2019
Diaphragm neuromuscular transmission failure in aged rats. Journal of neurophysiology\| PubMed ID: 31042426	2019
Anaesthetic care of patients undergoing primary hip and knee arthroplasty: consensus recommendations from the International Consensus on Anaesthesia-Related Outcomes after Surgery group (ICA... British journal of anaesthesia\| PubMed ID: 31351590	2019
Glutamatergic input varies with phrenic motor neuron size. Journal of neurophysiology\| PubMed ID: 31389739	2019
Heterogeneous glutamatergic receptor mRNA expression across phrenic motor neurons in rats. Journal of neurochemistry\| PubMed ID: 31563147	2020
Aging reduces succinate dehydrogenase activity in rat type IIx/IIb diaphragm muscle fibers. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 31774353	2020
Diaphragm muscle sarcopenia into very old age in mice. Physiological reports\| PubMed ID: 31908152	2020
Inhibition of TrkB kinase activity impairs transdiaphragmatic pressure generation. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 31944892	2020
Neuraxial anesthesia is associated with improved survival after total joint arthroplasty depending on frailty: a cohort study. Regional anesthesia and pain medicine\| PubMed ID: 32269138	2020
Preoperative Frailty Assessment: Comment. Anesthesiology\| PubMed ID: 32541550	2020
Disproportionate loss of excitatory inputs to smaller phrenic motor neurons following cervical spinal hemisection. The Journal of physiology\| PubMed ID: 32735344	2020
Peripheral Nerve Blockade with Combined Standard and Liposomal Bupivacaine in Major Lower-Extremity Amputation. Pain practice : the official journal of World Institute of Pain\| PubMed ID: 33058387	2021
How Is Surgical Risk Best Assessed? A Cohort Comparison of Measures in Total Joint Arthroplasty. The Journal of arthroplasty\| PubMed ID: 33071030	2021
Age-related impairment of autophagy in cervical motor neurons. Experimental gerontology\| PubMed ID: 33290859	2021
Three Risk Stratification Tools and Postoperative Pneumonia After Noncardiothoracic Surgery. The American surgeon\| PubMed ID: 33342277	2021
Quantifying mitochondrial volume density in phrenic motor neurons. Journal of neuroscience methods\| PubMed ID: 33549636	2021
TrkB signaling contributes to transdiaphragmatic pressure generation in aged mice. Journal of neurophysiology\| PubMed ID: 33596726	2021
Anesthesiologists Wake Up! It Is Time for Research and Innovative Medical Entrepreneurism. The journal of education in perioperative medicine : JEPM\| PubMed ID: 33778102	2021
Acute intrathecal BDNF enhances functional recovery after cervical spinal cord injury in rats. Journal of neurophysiology\| PubMed ID: 33949892	2021
Frailty Transitions One Year After Total Joint Arthroplasty: A Cohort Study. The Journal of arthroplasty\| PubMed ID: 34531097	2022
Automated evaluation of respiratory signals to provide insight into respiratory drive. Respiratory physiology & neurobiology\| PubMed ID: 35218924	2022
Cervical spinal hemisection alters phrenic motor neuron glutamatergic mRNA receptor expression. Experimental neurology\| PubMed ID: 35247372	2022
Mitochondrial adaptations to inactivity in diaphragm muscle fibers. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 35678745	2022
Brain derived neurotrophic factor/tropomyosin related kinase B signaling impacts diaphragm neuromuscular transmission in a novel rat chemogenetic model. Frontiers in cellular neuroscience\| PubMed ID: 36385943	2022
CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells. Scientific reports\| PubMed ID: 36781993	2023
Electrophysiological effects of BDNF and TrkB signaling at type-identified diaphragm neuromuscular junctions. Journal of neurophysiology\| PubMed ID: 36883761	2023
Size-dependent differences in mitochondrial volume density in phrenic motor neurons. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 37022966	2023
Chloroquine impairs maximal transdiaphragmatic pressure generation in old mice. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 37823202	2023
Neuromotor control of spontaneous quiet breathing in awake rats evaluated by assessments of diaphragm EMG stationarity. Journal of neurophysiology\| PubMed ID: 37877195	2023
Postanesthesia Care Unit and Anesthetic Management Outcomes Among Patients Undergoing Noncardiac Surgery: Differences by Race and Ethnicity. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses\| PubMed ID: 38323973	2024
Cervical spinal cord hemisection impacts sigh and the respiratory reset in male rats. Physiological reports\| PubMed ID: 38467570	2024
Enhanced Diaphragm Muscle Function upon Satellite Cell Transplantation in Dystrophic Mice. International journal of molecular sciences\| PubMed ID: 38473751	2024
Autophagy markers LC3 and p62 in aging lumbar motor neurons. Experimental gerontology\| PubMed ID: 38885913	2024
Identification of eupneic breathing using machine learning. Journal of neurophysiology\| PubMed ID: 39052237	2024
Hypercapnia impacts neural drive and timing of diaphragm neuromotor control. Journal of neurophysiology\| PubMed ID: 39548981	2024
Inhibition of TrkB kinase activity impairs autophagy in cervical motor neurons of young but not old mice. Experimental physiology\| PubMed ID: 39576170	2025
Chloroquine Affects Presynaptic Membrane Retrieval in Diaphragm Neuromuscular Junctions of Old Mice. International journal of molecular sciences\| PubMed ID: 39795904	2024
Editorial: Respiratory dysfunction in neurological disease and injury: novel mechanisms and potential therapeutics. Frontiers in physiology\| PubMed ID: 39958690	2025
Chloroquine Causes Aging-like Changes in Diaphragm Neuromuscular Junction Morphology in Mice. Cells\| PubMed ID: 40136639	2025
Stepping up to inspire in muscular dystrophy. The Journal of physiology\| PubMed ID: 40572037	2025
Impact of upper cervical spinal cord hemisection on diaphragm neuromotor control. Journal of neurophysiology\| PubMed ID: 40720229	2025