a-minimally-invasive-visualized-method-for-nasojejunal-tube-placement

A Minimally Invasive, Visualized Method for Nasojejunal Tube Placement

Malnutrition is a common issue in critically ill patients, often stemming from illness, injury, or surgery. Prolonged fasting leads to intestinal issues, ...

an-unusual-case-of-tuberculosis-infection-of-the-hand-with-peritonitis

An Unusual Case of Tuberculosis Infection of the Hand with Peritonitis

Tuberculosis (TB), primarily a pulmonary disease, manifests extrapulmonary involvement in 20% of cases, though concurrent infections in distant sites like ...

Zhejiang University School of Medicine

Schwannomas are the most common neoplastic lesions of the peripheral nerves when growing on the extremities, they usually have adverse effects on patients due to the exposed and functional nature of the region.

Clinical characteristics and management experience of schwannoma in extremities: Lessons learned from a 10-year retrospective study.

Peripheral nerve diseases are significantly correlated with severe fractures or trauma and surgeries, leading to poor life quality and impairment of physical and mental health. Human dental pulp stem cells (DPSCs) are neural crest stem cells with a strong multi-directional differentiation potential and proliferation capacity that provide a novel cell source for nerve regeneration. DPSCs are easily extracted from dental pulp tissue of human permanent or deciduous teeth. DPSCs can express neurotrophic and immunomodulatory factors and, subsequently, induce blood vessel formation and nerve regeneration. Therefore, DPSCs yield valuable therapeutic potential in the management of peripheral neuropathies. With the purpose of summarizing the advances in DPSCs and their potential applications in peripheral neuropathies, this article reviews the biological characteristics of DPSCs in association with the mechanisms of peripheral nerve regeneration.

The potential roles of dental pulp stem cells in peripheral nerve regeneration.

Brachial plexus injury (BPI) is one of the most destructive peripheral nerve injuries and there is still a lack of effective treatment.

The effects of melatonin in the treatment of acute brachial plexus compression injury in rats.

Acral melanoma (AM) is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate, largely due to the inconspicuous nature of early-stage lesions, which can lead to late diagnosis. Because of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas, early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities, including clinical examination, dermoscopy, histopathology, molecular testing, radiological imaging, and blood tests. While surgery is the preferred method of treatment for AM, other therapeutic options may be employed based on the stage and underlying etiology of the disease. Immune checkpoint inhibitors, molecular targeted therapy, radiotherapy, chemotherapy, and oncolytic virotherapy represent promising advanced treatment options for AM. In this review, we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM, highlighting the importance of early detection and the prompt, individualized management of this challenging disease.

Recent advancements in the diagnosis and treatment of acral melanoma.

This article emphasizes the essential role of radiological imaging in high-pressure injection injury (HPII) management and assesses the results of Magnetic Resonance Imaging (MRI) examinations in providing better details about foreign material extension and assisting surgeons in visualizing operational movement during surgery. Additionally, it shares the authors' experience in managing 16 HPII patients and investigates the application of bone cement in the treatment of injection injuries.

Advanced Diagnosis and Treatment Methods of High-Pressure Injection Injury: A Single-Center Retrospective Case Series Study.

Coronavirus disease 2019 (COVID-19) is a multi-system disease that can lead to various severe complications. Acute limb ischemia (ALI) has been increasingly recognized as a COVID-19-associated complication that often predicts a poor prognosis. However, the pathophysiology and molecular mechanisms underlying COVID-19-associated ALI remain poorly understood. Hypercoagulability and thrombosis are considered important mechanisms, but we also emphasize the roles of vasospasm, hypoxia, and acidosis in the pathogenesis of the disease. The angiotensin-converting enzyme 2 (ACE2) pathway, inflammation, and platelet activation may be important molecular mechanisms underlying these pathological changes induced by COVID-19. Furthermore, we discuss the hypotheses of risk factors for COVID-19-associated ALI from genetic, age, and gender perspectives based on our analysis of molecular mechanisms. Additionally, we summarize therapeutic approaches such as use of the interleukin-6 (IL-6) blocker tocilizumab, calcium channel blockers, and angiotensin-converting enzyme inhibitors, providing insights for the future treatment of coronavirus-associated limb ischemic diseases.

COVID-19 and acute limb ischemia: latest hypotheses of pathophysiology and molecular mechanisms.

The long noncoding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) has been extensively studied as an oncogenic factor. Antisense oligonucleotides (ASOs) labeled with the Cyanine5.5 (Cy5.5) dye enable effective in vivo imaging using near-infrared fluorescence.

ArticleTotal : 2	Year
Publication title Cited by 2	2024
Publication title	2025

Article	Year
Clinical characteristics and management experience of schwannoma in extremities: Lessons learned from a 10-year retrospective study. Frontiers in neurology\| PubMed ID: 36588891	2022
The potential roles of dental pulp stem cells in peripheral nerve regeneration. Frontiers in neurology\| PubMed ID: 36712432	2022
The effects of melatonin in the treatment of acute brachial plexus compression injury in rats. Frontiers in neurology\| PubMed ID: 36937512	2023
Recent advancements in the diagnosis and treatment of acral melanoma. Journal of Zhejiang University. Science. B\| PubMed ID: 38303495	2024
Advanced Diagnosis and Treatment Methods of High-Pressure Injection Injury: A Single-Center Retrospective Case Series Study. Annali italiani di chirurgia\| PubMed ID: 40234234	2025
COVID-19 and acute limb ischemia: latest hypotheses of pathophysiology and molecular mechanisms. Journal of Zhejiang University. Science. B\| PubMed ID: 40274383	2025
Fluorescence imaging of MALAT1 expression using a Cy5.5-labeled antisense oligonucleotide in lung cancer and epidermal carcinoma cells. Cancer imaging : the official publication of the International Cancer Imaging Society\| PubMed ID: 40597438	2025

Chengjun Yao

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