David L. Wiest

Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2024

Other Publications

Article	Year
Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required. The Journal of experimental medicine\| PubMed ID: 9348303	1997
ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck). The Journal of experimental medicine\| PubMed ID: 10190908	1999
Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo. The Journal of experimental medicine\| PubMed ID: 10587355	1999
Early growth response transcription factors are required for development of CD4(-)CD8(-) thymocytes to the CD4(+)CD8(+) stage. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11823493	2002
Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12626535	2003
Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15879115	2005
Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage. Immunity\| PubMed ID: 15894277	2005
Recent insights into the signals that control alphabeta/gammadelta-lineage fate. Immunological reviews\| PubMed ID: 16448543	2006
T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. Blood\| PubMed ID: 17170122	2007
High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Science's STKE : signal transduction knowledge environment\| PubMed ID: 17551170	2007
Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17878368	2007
A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice. Cancer research\| PubMed ID: 18316591	2008
Early growth response genes regulate B cell development, proliferation, and immune response. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802061	2008
Egr2 is required for Bcl-2 induction during positive selection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19017967	2008
Pre-TCR-induced beta-catenin facilitates traversal through beta-selection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19124717	2009
Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19124718	2009
Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 19145458	2009
Identification of the last cog in a ligand-independent signaling machine? Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19380757	2009
Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice. Genes, chromosomes & cancer\| PubMed ID: 19530243	2009
Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity\| PubMed ID: 19833086	2009
Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice. Seminars in immunology\| PubMed ID: 20471282	2010
Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20483745	2010
Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development. Genesis (New York, N.Y. : 2000)\| PubMed ID: 20665729	2010
Cutting edge: Intrinsic programming of thymic γδT cells for specific peripheral tissue localization. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21068400	2010
Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21690328	2011
Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22357628	2012
CD45-deficient severe combined immunodeficiency caused by uniparental disomy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22689986	2012
Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood\| PubMed ID: 22976955	2012
Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22988097	2012
A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23355739	2013
Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Developmental cell\| PubMed ID: 23449473	2013
The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. PLoS genetics\| PubMed ID: 23990801	2013
The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification. The Journal of experimental medicine\| PubMed ID: 24493796	2014
Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24706811	2014
Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes γδ T-cell commitment by enhancing TCR signal strength. European journal of immunology\| PubMed ID: 24935715	2014
Origins of γδ T cell effector subsets: a riddle wrapped in an enigma. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25326547	2014
Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25416806	2015
Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates. Immunity\| PubMed ID: 25526308	2014
Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. PloS one\| PubMed ID: 26161877	2015
Development of γδ T Cells, the Special-Force Soldiers of the Immune System. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26294395	2016
Using the Zebrafish Model to Study T Cell Development. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26294415	2016
Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts. Journal of cellular physiology\| PubMed ID: 26445298	2016
Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks. Critical reviews in immunology\| PubMed ID: 26853850	2015
Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma. Cancer research\| PubMed ID: 27197189	2016
The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin. Cancer research\| PubMed ID: 27197267	2016
Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects. The Journal of experimental medicine\| PubMed ID: 27432940	2016
Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27489283	2016
JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia. Leukemia\| PubMed ID: 27840425	2017
Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B. The New England journal of medicine\| PubMed ID: 27959755	2016
Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell reports\| PubMed ID: 28076796	2017
The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling. Oncotarget\| PubMed ID: 28122332	2017
THEMIS-tery is solved. Nature immunology\| PubMed ID: 28323266	2017
Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate. Cell\| PubMed ID: 28938112	2017
Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in . Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29127144	2017
HEB is required for the specification of fetal IL-17-producing γδ T cells. Nature communications\| PubMed ID: 29222418	2017
Role of a selecting ligand in shaping the murine γδ-TCR repertoire. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29432160	2018
Reply to Chien: Clarification of the effect of ligand on γδ-TCR repertoire selection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29615510	2018
Integration of T-cell receptor, Notch and cytokine signals programs mouse γδ T-cell effector differentiation. Immunology and cell biology\| PubMed ID: 29754419	2018
Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30012846	2018
Functional genomic landscape of acute myeloid leukaemia. Nature\| PubMed ID: 30333627	2018
Gadd45 stress sensors in suppression of leukemia. Oncotarget\| PubMed ID: 30344933	2018
RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance. PloS one\| PubMed ID: 31581233	2019
Recent advances in understanding the development and function of γδ T cells. F1000Research\| PubMed ID: 32399190	2020
NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma. Cell reports\| PubMed ID: 32579914	2020
The E protein-TCF1 axis controls γδ T cell development and effector fate. Cell reports\| PubMed ID: 33535043	2021
Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo. Cell reports\| PubMed ID: 34107257	2021
A Novel Germline Heterozygous Variant Causing Severe Atopic Disease and Immune Dysregulation. Frontiers in immunology\| PubMed ID: 34887873	2021
Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 35046107	2022
The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm. Blood\| PubMed ID: 35436326	2022
IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma. Cancer discovery\| PubMed ID: 35723626	2022
Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency. Frontiers in immunology\| PubMed ID: 35967429	2022
Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 36374451	2023
Zebrafish: A Tractable Model for Analysis of T Cell Development. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 36374469	2023
Transcription factor EGR2 controls homing and pathogenicity of T17 cells in the central nervous system. Nature immunology\| PubMed ID: 37443284	2023
Doubling down to make killer T cells. Nature immunology\| PubMed ID: 37620604	2023
Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD. Blood\| PubMed ID: 37871574	2024
Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death. The Journal of biological chemistry\| PubMed ID: 38522521	2024
E proteins control the development of NKγδT cells through their invariant T cell receptor. Nature communications\| PubMed ID: 38871720	2024