John F. X. Diffley

Chromosome Replication Laboratory, Francis Crick Institute

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Author's overview: identifying SARS-CoV-2 antiviral compounds. The Biochemical journal\| PubMed ID: 34198320	2021
Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex. The Journal of biological chemistry\| PubMed ID: 26719337	2016
On the road to replication. EMBO molecular medicine\| PubMed ID: 26787652	2016
MCM: one ring to rule them all. Current opinion in structural biology\| PubMed ID: 26866665	2016
Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation. The EMBO journal\| PubMed ID: 26912723	2016
Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates. Molecular cell\| PubMed ID: 27989438	2017
How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication. Molecular cell\| PubMed ID: 27989442	2017
CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28373564	2017
Cdt1 stabilizes an open MCM ring for helicase loading. Nature communications\| PubMed ID: 28643783	2017
Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading. Science (New York, N.Y.)\| PubMed ID: 28729513	2017
Cryo-EM structure of a licensed DNA replication origin. Nature communications\| PubMed ID: 29269875	2017
The mechanism of eukaryotic CMG helicase activation. Nature\| PubMed ID: 29489749	2018
Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome. Nature communications\| PubMed ID: 30498216	2018
Rpd3L Contributes to the DNA Damage Sensitivity of Checkpoint Mutants. Genetics\| PubMed ID: 30559326	2019
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM. Nature\| PubMed ID: 31748745	2019
Multiplex Cell Fate Tracking by Flow Cytometry. Methods and protocols\| PubMed ID: 32709120	2020
DNA replication origins retain mobile licensing proteins. Nature communications\| PubMed ID: 33772005	2021
Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro. Nucleic acids research\| PubMed ID: 34048583	2021
Unchecked nick ligation can promote localized genome re-replication. Current biology : CB\| PubMed ID: 34102115	2021
An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques. RSC advances\| PubMed ID: 34178310	2021
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase. The Biochemical journal\| PubMed ID: 34198322	2021
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase. The Biochemical journal\| PubMed ID: 34198323	2021
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease. The Biochemical journal\| PubMed ID: 34198324	2021
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease. The Biochemical journal\| PubMed ID: 34198325	2021
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease. The Biochemical journal\| PubMed ID: 34198326	2021
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease. The Biochemical journal\| PubMed ID: 34198327	2021
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. The Biochemical journal\| PubMed ID: 34198328	2021
Eukaryotic DNA replication with purified budding yeast proteins. Methods in enzymology\| PubMed ID: 34776208	2021
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nature structural & molecular biology\| PubMed ID: 34963704	2022
The Initiation of Eukaryotic DNA Replication. Annual review of biochemistry\| PubMed ID: 35320688	2022
Mechanism of replication origin melting nucleated by CMG helicase assembly. Nature\| PubMed ID: 35705812	2022
A DNA replication fork-centric view of the budding yeast DNA damage response. DNA repair\| PubMed ID: 36108423	2022
Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication. Cell\| PubMed ID: 36681079	2023
A replication fork determinant for the establishment of sister chromatid cohesion. Cell\| PubMed ID: 36693376	2023
Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation. Nature communications\| PubMed ID: 37059705	2023
A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint. Nature communications\| PubMed ID: 37872142	2023
Unwinding of a eukaryotic origin of replication visualized by cryo-EM. Nature structural & molecular biology\| PubMed ID: 38760633	2024