identifying-frailty-using-point-care-ultrasonography-image

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

Frailty is a significant predictor of a range of adverse outcomes in surgical patients, including increased mechanical ventilation time, longer hospital ...

Duke University School of Medicine, Duke University Health System

Pulse oximeters may delay displaying the correct oxygen saturation during the onset of hypoxia. We investigated the desaturation response times of pulse oximeter sensors (forehead, ear and finger) during vasoconstriction due to mild hypothermia and vasodilation caused by glyceryl trinitrate. Ten healthy male volunteers were given three hypoxic challenges of 3 min duration under differing experimental conditions. Mild hypothermia increased the mean response time of finger oximeters from 130 to 215 s. Glyceryl trinitrate partly offset this effect by reducing the response time from 215 to 187 s. In contrast, the response times of the forehead and ear oximeters were unaffected by mild hypothermia, but the difference between head and finger oximeters was highly significant (p < 0.0001). The results suggest that the head oximeters provide a better monitoring site for pulse oximeters during mild hypothermia.

The desaturation response time of finger pulse oximeters during mild hypothermia.

Cerebral oximetry may be a valuable monitor, but few validation data are available, and most report the change from baseline rather than absolute accuracy, which may be affected by individuals whose oximetric values are outside the expected range. The authors sought to develop and validate a cerebral oximeter capable of absolute accuracy.

Development and validation of a cerebral oximeter capable of absolute accuracy.

Rapid delivery of potent opioid to the systemic circulation is an important feature for the effective treatment of acute and acute-on-chronic breakthrough pain. The delivery of different opioids by the pulmonary route has been inconsistent, usually resulting in low bioavailability of the drug. Staccato® Fentanyl for Inhalation is a handheld inhaler producing a single metered dose of aerosolized fentanyl during a single inspiration. The aerosol is of high purity (≥98%) at a particle size (1 to 3.5 microns) shown to be best for pulmonary absorption.

Article	Year
The desaturation response time of finger pulse oximeters during mild hypothermia. Anaesthesia\| PubMed ID: 15601275	2005
Development and validation of a cerebral oximeter capable of absolute accuracy. Journal of cardiothoracic and vascular anesthesia\| PubMed ID: 22883447	2012
Inhaled fentanyl aerosol in healthy volunteers: pharmacokinetics and pharmacodynamics. Anesthesia and analgesia\| PubMed ID: 22984155	2012

David B. MacLeod

Biography

JoVE Journal Publications

Other Publications