Patrick M. Woster

Drug Discovery and Biomedical Sciences, Medical University of South Carolina

Affiliated withMedical University of South Carolina

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino acids\| PubMed ID: 21805138	2012
Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer... Amino acids\| PubMed ID: 21814790	2012
Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities. Journal of medicinal chemistry\| PubMed ID: 21882831	2011
Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. The Journal of biological chemistry\| PubMed ID: 22025614	2011
Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds. Biochemical and biophysical research communications\| PubMed ID: 22469467	2012
Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1. Journal of medicinal chemistry\| PubMed ID: 22876979	2012
Loss of Lysine-Specific Demethylase 1 (LSD1) suppresses growth and alters gene expression of human colon cancer cells in a p53 and DNA methyltransferase 1 (DNMT1) independent manner. The Biochemical journal\| PubMed ID: 23072722	2012
Polyamine-based small molecule epigenetic modulators. MedChemComm\| PubMed ID: 23293738	2012
Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert reviews in molecular medicine\| PubMed ID: 23432971	2013
The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines. Amino acids\| PubMed ID: 23508577	2014
Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites. Amino acids\| PubMed ID: 23884694	2013
Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism. Molecular cancer therapeutics\| PubMed ID: 23943804	2013
P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs against multi-d... Journal of molecular graphics & modelling\| PubMed ID: 24291501	2014
Design of small molecule epigenetic modulators. Bioorganic & medicinal chemistry letters\| PubMed ID: 24300735	2014
Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1. ACS medicinal chemistry letters\| PubMed ID: 24883177	2014
Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene\| PubMed ID: 25174398	2015
3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors. MedChemComm\| PubMed ID: 25580204	2014
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorganic & medicinal chemistry\| PubMed ID: 25684422	2015
Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. The Journal of biological chemistry\| PubMed ID: 25713082	2015
Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. Bioorganic & medicinal chemistry\| PubMed ID: 25725609	2015
Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group. MedChemComm\| PubMed ID: 26005563	2015
Epigenetics: Novel Therapeutics Targeting Epigenetics. Journal of medicinal chemistry\| PubMed ID: 26824165	2016
Antibacterial Diamines Targeting Bacterial Membranes. Journal of medicinal chemistry\| PubMed ID: 26964758	2016
Targeting polyamine metabolism for cancer therapy and prevention. The Biochemical journal\| PubMed ID: 27679855	2016
Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. European journal of medicinal chemistry\| PubMed ID: 29459279	2018
Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2... Bioorganic & medicinal chemistry\| PubMed ID: 29859749	2018
Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis. Epigenetics\| PubMed ID: 29927684	2018
Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. PloS one\| PubMed ID: 30138353	2018
Polyamine catabolism and oxidative damage. The Journal of biological chemistry\| PubMed ID: 30333229	2018
Novel Synthetic Polyamines Have Potent Antimalarial Activities and by Decreasing Intracellular Spermidine and Spermine Concentrations. Frontiers in cellular and infection microbiology\| PubMed ID: 30838177	2019
Citizenship in the World of Medicinal Chemistry: 25 Years as an ACSMEDI Volunteer. ACS medicinal chemistry letters\| PubMed ID: 31097983	2019
Dual inhibitors of LSD1 and spermine oxidase. MedChemComm\| PubMed ID: 31191868	2019
Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice. Free radical biology & medicine\| PubMed ID: 31557514	2019
Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Oncogene\| PubMed ID: 32350444	2020
Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease. ACS omega\| PubMed ID: 32596612	2020
Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 34133404	2021
The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme. Cancer gene therapy\| PubMed ID: 34522028	2022
Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice. Autophagy\| PubMed ID: 35293288	2022
Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 35447542	2022
Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation. RSC advances\| PubMed ID: 35497564	2021
New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives. Chembiochem : a European journal of chemical biology\| PubMed ID: 36106425	2022
Identification and Characterization of Novel Small-Molecule SMOX Inhibitors. Medical sciences (Basel, Switzerland)\| PubMed ID: 36135832	2022
Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma. European journal of medicinal chemistry\| PubMed ID: 36223680	2022
Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma. Chemical science\| PubMed ID: 36845935	2023
Establishing New Isosexual Pairs in Adult Male Guinea Pigs () to Facilitate Social Housing. Journal of the American Association for Laboratory Animal Science : JAALAS\| PubMed ID: 38262624	2024