assessing-antibody-dependent-cell-mediated-cytotoxicity-cancer-cells

Assessing Antibody-dependent, Cell-mediated Cytotoxicity in Cancer Cells using Antibody-Dependent Cell-Mediated Cytotoxicity Reporter Bioassay

The method for antibody-dependent, cell-mediated cytotoxicity (ADCC) represents an important tool to assess the efficacy of therapeutic antibodies in ...

A*STAR 61 Biopolis Drive

To evaluate long-term changes in mean keratometry, astigmatism, true net power (TNP), and total corneal refractive power (TCRP) of corneas after primary pterygium excision.

Long-Term Stability of Keratometry, Scheimpflug-Derived True Net Power, and Total Corneal Refractive Power After Primary Pterygium Excision.

Use next-generation sequencing (NGS) technology to improve our diagnostic yield in patients with suspected genetic disorders in the Asian setting.

Singapore Undiagnosed Disease Program: Genomic Analysis aids Diagnosis and Clinical Management.

Family history has traditionally been an essential part of clinical care to assess health risks. However, declining sequencing costs have precipitated a shift towards genomics-first approaches in population screening programs rendering the value of family history unknown. We evaluated the utility of incorporating family history information for genomic sequencing selection.

Family history assessment significantly enhances delivery of precision medicine in the genomics era.

Correction to: Family history assessment significantly enhances delivery of precision medicine in the genomics era.

Asian populations are under-represented in human genomics research. Here, we characterize clinically significant genetic variation in 9051 genomes representing East Asian, South Asian, and severely under-represented Austronesian-speaking Southeast Asian ancestries. We observe disparate genetic risk burden attributable to ancestry-specific recurrent variants and identify individuals with variants specific to ancestries discordant to their self-reported ethnicity, mostly due to cryptic admixture. About 27% of severe recessive disorder genes with appreciable carrier frequencies in Asians are missed by carrier screening panels, and we estimate 0.5% Asian couples at-risk of having an affected child. Prevalence of medically-actionable variant carriers is 3.4% and a further 1.6% harbour variants with potential for pathogenic classification upon additional clinical/experimental evidence. We profile 23 pharmacogenes with high-confidence gene-drug associations and find 22.4% of Asians at-risk of Centers for Disease Control and Prevention Tier 1 genetic conditions concurrently harbour pharmacogenetic variants with actionable phenotypes, highlighting the benefits of pre-emptive pharmacogenomics. Our findings illuminate the diversity in genetic disease epidemiology and opportunities for precision medicine for a large, diverse Asian population.

Article	Year
Long-Term Stability of Keratometry, Scheimpflug-Derived True Net Power, and Total Corneal Refractive Power After Primary Pterygium Excision. Cornea\| PubMed ID: 28938377	2017
Singapore Undiagnosed Disease Program: Genomic Analysis aids Diagnosis and Clinical Management. Archives of disease in childhood\| PubMed ID: 32819910	2021
Family history assessment significantly enhances delivery of precision medicine in the genomics era. Genome medicine\| PubMed ID: 33413596	2021
Correction to: Family history assessment significantly enhances delivery of precision medicine in the genomics era. Genome medicine\| PubMed ID: 34225778	2021
Analysis of clinically relevant variants from ancestrally diverse Asian genomes. Nature communications\| PubMed ID: 36335097	2022
Conflict of Interest Disclosures. Global spine journal\| PubMed ID: 38726630	2024

Kelvin Kam Yew Kuan

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